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Results for "

astragalus

" in MedChemExpress (MCE) Product Catalog:

37

Inhibitors & Agonists

2

Biochemical Assay Reagents

35

Natural
Products

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0431
    Astragaloside IV
    Maximum Cited Publications
    35 Publications Verification

    		 MMP ERK JNK Cancer
    Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV
  • HY-N0433
    Astragaloside II
    1 Publications Verification

    Astrasieversianin VIII

    		 Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB Inflammation/Immunology Endocrinology Cancer
    Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
    Astragaloside II
  • HY-N0432
    Astragaloside I

    Astrasieversianin IV; Cyclosieversioside B

    		 Wnt β-catenin Metabolic Disease
    Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through activating the Wnt/β-catenin signaling pathway .
    Astragaloside I
  • HY-N1353
    Rhamnocitrin
    2 Publications Verification

    		 p38 MAPK Cardiovascular Disease Inflammation/Immunology
    Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
    Rhamnocitrin
  • HY-159066
    Polysachoride of astragalus mongholicus

    		Biochemical Assay Reagents Inflammation/Immunology
    Polysachoride of astragalus mongholicus is an astragalus polysaccharide that can be isolated from Astragalus Mongholicus, exhibits antifibrotic activity .
    Polysachoride of astragalus mongholicus
  • HY-N0431R
    Astragaloside IV (Standard)

    		Reference Standards MMP ERK JNK Cancer
    Astragaloside IV (Standard) is the analytical standard of Astragaloside IV. This product is intended for research and analytical applications. Astragaloside IV, an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells.
    Astragaloside IV (Standard)
  • HY-N0434
    Astragaloside III
    2 Publications Verification

    		 C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus Infection Cancer
    Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .
    Astragaloside III
  • HY-N0424
    Cyclogalegenin

    Cyclogalegigenin

    		 Others Others
    Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol.
    Cyclogalegenin
  • HY-W250121
    Tragacanth gum

    		Environmental Pollutants Biochemical Assay Reagents Infection Inflammation/Immunology Cancer
    Tragacanth gum is an orally active anionic composite polysaccharide and multifunctional biomaterial. Tragacanth gum exhibits biocompatibility, mucoadhesion and renoprotective effects, and effectively promotes wound closure and tissue healing. Tragacanth gum can be isolated from Astragalus gummifer. Tragacanth gum acts as an emulsifier and drug delivery carrier, and is also widely used in fields such as 3D scaffolds, tissue engineering and green nanoparticle preparation. High doses of Tragacanth gum may induce reversible forestomach squamous epithelial hyperplasia in mice, but show no mutagenic or carcinogenic activity. Tragacanth gum is commonly used in studies related to diseases including systemic candidiasis, rheumatoid arthritis and osteosarcoma .
    Tragacanth gum
  • HY-N2473
    Methylnissolin-3-O-glucoside
    2 Publications Verification

    		 Others Inflammation/Immunology
    Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
    Methylnissolin-3-O-glucoside
  • HY-N4005
    Isoastilbin

    		Bacterial Tyrosinase Infection Neurological Disease
    Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL, and also inhibits tyrosinase activity. Isoastilbin shows neuroprotective, antioxidation, antimicrobial and anti-apoptotic properties and has the potential for Alzheimer’s disease research .
    Isoastilbin
  • HY-N0888
    Isoastragaloside II

    Astrasieversianin-VII

    		 Others Others
    Isoastragaloside II is an astragaloside, which is isolated from the hairy root culture of Astragalus membranaceus.
    Isoastragaloside II
  • HY-N9989
    Brachyoside B

    		Others Others
    Brachyoside B is a triterpenoid saponin from Astragalus wiedemannianus .
    Brachyoside B
  • HY-N11472
    Rhamnocitrin 3-glucoside

    Rhamnocitrin-3-O-β-D-glucopyranoside

    		 Others Others
    Rhamnocitrin 3-glucoside (Rhamnocitrin-3-O-β-D-glucopyranoside) is a natural product that can be isolated from Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao (AM) .
    Rhamnocitrin 3-glucoside
  • HY-N12954
    (R)-Mucronulatol

    		Bacterial Infection
    (R)-Mucronulatol is a flavonoid that can be isolated from Astragalus adsurgens. (R)-Mucronulatol shows antibacterial activity against Escherichia coli, Bacillus cereus, Staphylococcus aureus, Erwinia carotovora and Bacillus subtili, with MICs of 15.5, 15.5, 7.8, 7.8, 15.5 μg/mL respectively .
    (R)-Mucronulatol
  • HY-N0887
    Isoastragaloside I
    2 Publications Verification

    Isoastragaloside-I

    		 Akt NF-κB p38 MAPK PI3K FXR Keap1-Nrf2 NO Synthase COX Interleukin Related Integrin TGF-β Receptor Reactive Oxygen Species (ROS) Neurological Disease Metabolic Disease Inflammation/Immunology
    Isoastragaloside I is a natural compound found in Astragalus membranaceus, with oral activity and multiple biological activities such as anti-inflammatory and antioxidant properties. Isoastragaloside I inhibits Akt, NF-κB, MAPKs and PI3K, enhances the activity of hepatic FXR, regulates the TGF-β/Smads signaling pathway, and upregulates antioxidant molecules downstream of Nrf2. Isoastragaloside I inhibits the expression of NO, TNF-α, iNOS, COX-2, IL-1β and VCAM-1, and reduces intracellular ROS levels. Isoastragaloside I attenuates blood-brain barrier disruption, restores intestinal barrier function, increases β-cell mass, improves glucose homeostasis, and elevates circulating adiponectin levels. Isoastragaloside I can be used for the study of neuroinflammation-related neurodegenerative diseases, cholestatic liver disease, and diabetes .
    Isoastragaloside I
  • HY-N10048
    Agroastragaloside I

    		Others Others
    Agroastragaloside I is a astragaloside, and can be isolated from the hairy root cultures of Astragalus membranaceus .
    Agroastragaloside I
  • HY-N6250
    Isomucronulatol 7-O-glucoside

    Isomucronulatol 7-O-β-glucoside

    		 NO Synthase Interleukin Related Inflammation/Immunology
    Isomucronulatol 7-O-glucoside (Isomucronulatol 7-O-β-D-glucoside) is an isoflavonoid glycoside isolated from the roots of Astragalus membranaceus. Isomucronulatol 7-O-glucoside targets inflammation-related pathways in vitro to exert anti-inflammatory activity without cytotoxicity at effective concentrations. Isomucucronulatol 7-O-glucoside inhibits NO production and weakly suppresses IL‑12 p40 production in vitro. Isomucronulatol 7-O-glucoside can be used for the research on inflammation .
    Isomucronulatol 7-O-glucoside
  • HY-N9880
    Tamarixin

    		Bacterial Infection Inflammation/Immunology Cancer
    Tamarixin is flavonoid that isolated from Astragalus tanae Sosn that has hepatoprotective, antioxidant, anticancer, and antimicrobial activities .
    Tamarixin
  • HY-N0624
    Complanatoside A

    		Others Cancer
    Complanatoside A is a flavonol glycoside isolated from Astragalus complanatus, and currently it is used as a quality control index for A. complanatus in the 2010 edition of the Chinese Pharmacopoeia.
    Complanatoside A
  • HY-N0424R
    Cyclogalegenin (Standard)

    Cyclogalegigenin (Standard)

    		 Reference Standards Others Others
    Cyclogalegenin (Standard) is the analytical standard of Cyclogalegenin. This product is intended for research and analytical applications. Cyclogalegenin (Cyclogalegigenin) is an isoprenoid. Cyclogalegenin can be isolated from Astragalus galegiformis. Cyclogalegenin is an isomer of cycloastragenol .
    Cyclogalegenin (Standard)
  • HY-N10597
    5'''-O-Feruloyl complanatoside B

    		Others Cardiovascular Disease Metabolic Disease Cancer
    5'''-O-Feruloyl complanatoside B is isolated from Astragali Semen, the seeds of Astragalus Complanatus. Semen Astragali Complanati (SAC) include fatty acids, amino acids, polysaccharides, flavonoids, triterpene glycosides and trace elements; have been reported to involve in chronic diseases such as cardiovascular diseases, diabetes mellitus and cancers .
    5'''-O-Feruloyl complanatoside B
  • HY-N10644
    Complanatin

    		Others Others
    Complanatin is an acylated flavonol glycoside, it can be isolated from Astragalus complanatus R. Br .
    Complanatin
  • HY-N1985
    Acetylastragaloside I

    		Parasite Infection
    Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection .
    Acetylastragaloside I
  • HY-108268
    Cyclocephaloside II

    		Biochemical Assay Reagents Others
    Cyclocephaloside II is a natural product that can be obtained from the roots of Astragalus brachypterus and Astragalus microcephalus .
    Cyclocephaloside II
  • HY-N11450
    Complanatin I

    		Others Others
    Complanatin I is a natural product that can be isolated from Astragalus complanatus .
    Complanatin I
  • HY-N4212
    Astraganoside

    		Others Others
    Astraganoside, an isoflavane compound, isolated from the roots of Astragalus membranaceus (known as ‘‘Huangqi’’) .
    Astraganoside
  • HY-W009713R
    3,4,5-Trimethoxyphenylacetic acid (Standard)

    		Reference Standards Drug Metabolite Neurological Disease
    Cyclogalegenin (Standard) is the analytical standard of Cyclogalegenin. This product is intended for research and analytical applications. Cyclogalegenin (Cyclogalegigenin) is a isoprenoid that can be isolated from Astragalus galegiformis. Cyclogalegenin is the enantiomer of Cycloastragenol .
    3,4,5-Trimethoxyphenylacetic acid (Standard)
  • HY-N0432R
    Astragaloside I (Standard)

    Astrasieversianin IV (Standard); Cyclosieversioside B (Standard)

    		 Reference Standards Wnt β-catenin Metabolic Disease
    Astragaloside I (Standard) is the analytical standard of Astragaloside I. This product is intended for research and analytical applications. Astragaloside I, one of the main active ingredients in Astragalus membranaceus, has osteogenic properties. Astragaloside I stimulates osteoblast differentiation through the Wnt/β-catenin signaling pathway .
    Astragaloside I (Standard)
  • HY-N2473R
    Methylnissolin-3-O-glucoside (Standard)

    		Reference Standards Others Inflammation/Immunology
    Methylnissolin-3-O-glucoside (Standard) is the analytical standard of Methylnissolin-3-O-glucoside. This product is intended for research and analytical applications. Methylnissolin-3-O-glucoside (Methylnissolin-3-O-β-D-glucoside) is a flavonoid from the roots of Astragalus membranaceus with anti-inflammatory effects .
    Methylnissolin-3-O-glucoside (Standard)
  • HY-N1353R
    Rhamnocitrin (Standard)

    		Reference Standards Others p38 MAPK Cardiovascular Disease Inflammation/Immunology
    Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells) .
    Rhamnocitrin (Standard)
  • HY-N12742
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside

    		Others Inflammation/Immunology
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside (compound 4) is an inhibitor of collagenase and elastase with potential anti-inflammatory activity. Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside can be isolated from the methanol extract of the Balkan endemic species Astragalus thracicus Griseb .
    Tamarixetin 3-O-β-d-apiofuranosyl-(1 → 2)-β-d-galactopyranoside
  • HY-N0434R
    Astragaloside III (Standard)

    		Reference Standards C-type Lectin-like Receptors (CTLRs) Apoptosis Dengue Virus Infection Cancer
    Astragaloside III (Standard) is the analytical standard of Astragaloside III (HY-N0434). This product is intended for research and analytical applications. Astragaloside III is a triterpenoid saponin. Astragaloside III can be extracted from Astragalus root. Astragaloside III increases NKG2D and induces TACE phosphorylation. Astragaloside III induces Apoptosis. Astragaloside III has antiviral activity against dengue serotypes 1 and 3. Astragaloside III has anticancer activity against breast and colon cancer .
    Astragaloside III (Standard)
  • HY-N10645
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside

    		Others Others
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside is a flavonol O-glycoside, isolated from Astragali semen of leguminous plants .
    Rhamnocitrin 3-O-β-D-apiofuranosyl(1→2)-β-D-glucopyranoside
  • HY-N0433R
    Astragaloside II (Standard)

    Astrasieversianin VIII (Standard)

    		 Reference Standards Autophagy Interleukin Related HIF/HIF Prolyl-Hydroxylase SOD NF-κB Inflammation/Immunology Endocrinology Cancer
    Astragaloside II (Standard) is the analytical standard of Astragaloside II (HY-N0433). This product is intended for research and analytical applications. Astragaloside II is an orally active Cycloartane-type triterpene glycoside. Astragaloside II can be extracted from Astragalus membranaceus. Astragaloside II inhibits Autophagy, decreases pro-inflammatory cytokines (IL-6, IL-1β), HIF-α, p-p65, p-IκB and increases SOD. Astragaloside II regulates immunity and reduces inflammatory responses. Astragaloside II can be used in the research of diseases such as liver cancer, osteoporosis, immunosuppressive diseases, and ulcerative colitis .
    Astragaloside II (Standard)
  • HY-N18320
    Astrachrysoside A

    		Drug Derivative Others
    Astrachrysoside A is a cycloartane-type triterpene glycoside found in Astragalus wiedemannianus .
    Astrachrysoside A
  • HY-N16942
    Maltol 3-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside

    		Drug Derivative Others
    Maltol 3-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside is a natural phenolic compound.
    Maltol 3-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside

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