Search Result

Pathways Recommended:	Stem Cell/Wnt Cell Cycle/DNA Damage

Results for "

cerebellar granule cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Aminopeptidase (2) Apoptosis (4) Autophagy (1) Bcl-2 Family (1) Carboxypeptidase (1) Caspase (3) CaSR (1) CDK (1) Cholinesterase (ChE) (2) COX (2) Cytochrome P450 (1) Endogenous Metabolite (1) GABA Receptor (2) GSK-3 (1) Hedgehog (1) iGluR (2) mGluR (6) mTOR (1) nAChR (1) NO Synthase (2) OLIG2 (1) p38 MAPK (2) PARP (1) PI3K (1) Potassium Channel (1) Prolyl Endopeptidase (PREP) (1) RAR/RXR (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Smo (2) TNF Receptor (2)
By Research Areas:	Cancer (5) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (18)

By Targets:

Akt (1)

Aminopeptidase (2)

Apoptosis (4)

Autophagy (1)

Bcl-2 Family (1)

Carboxypeptidase (1)

Caspase (3)

CaSR (1)

CDK (1)

Cholinesterase (ChE) (2)

COX (2)

Cytochrome P450 (1)

Endogenous Metabolite (1)

GABA Receptor (2)

GSK-3 (1)

Hedgehog (1)

iGluR (2)

mGluR (6)

mTOR (1)

nAChR (1)

NO Synthase (2)

OLIG2 (1)

p38 MAPK (2)

PARP (1)

PI3K (1)

Potassium Channel (1)

Prolyl Endopeptidase (PREP) (1)

RAR/RXR (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

Smo (2)

TNF Receptor (2)

By Research Areas:

Cancer (5)

Cardiovascular Disease (2)

Inflammation/Immunology (3)

Metabolic Disease (1)

Neurological Disease (18)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: Nuclear Factor of activated T Cells (NFAT) TREM receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W040045

Callistephin chloride 1 Publications Verification Pelargonidin-3-O-glucoside chloride	Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK TNF Receptor Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis .

HY-W677042

α-Androstenol 5α-Androst-16-en-3α-ol	GABA Receptor	Neurological Disease
α-Androstenol (5α-Androst-16-en-3α-ol) is a steroid pheromone that has been found in boar testes and male axillary sweat. α-Androstenol is also a positive allosteric modulator of GABAA receptors, which enhances GABA-activated currents in primary mouse cerebellar granule cells (EC₅₀ of 0.4 μM). α-Androstenol produces anxiolytic-like, antidepressant-like, and anticonvulsant effects in mice. α-Androstenol can be used for the research of seizures .

HY-157959

Orphenadrine (±)-Orphenadrine	iGluR Cytochrome P450 Cholinesterase (ChE)	Neurological Disease Cancer
Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of ^[3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and CYP2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation .

HY-179078

CT-179	OLIG2 Apoptosis Caspase PARP	Neurological Disease Cancer
CT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC₅₀ of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G₂/M phase arrest and increases G₀ population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma .

HY-B0877

Halcinonide 1 Publications Verification SQ-18566	Smo Caspase RAR/RXR CDK	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Halcinonide (SQ-18566) is an orally active Smoothened (Smo) agonist. Halcinonide activates the Hedgehog signaling pathway by binding to Smo and promoting its internalization and expression, thereby activating Gli transcription factors. Halcinonide not only stimulates cell proliferation, increases the expression of cyclin D2/CDK6 and inhibits the degradation of caspase-3, but also suppresses Bcl-2/Bax-mediated apoptosis, oxidative stress and inflammatory responses. Halcinonide activates RxRγ to upregulate the expression of myelin genes, thereby reducing cerebral infarction and improving behavioral deficits. Halcinonide has been used in studies related to multiple sclerosis and ischemic stroke .

HY-130553

β-Spaglumic acid 1 Publications Verification β-NAAG; β-N-Acetylaspartylglutamic acid	Aminopeptidase mGluR	Neurological Disease
β-Spaglumic acid (β-NAAG) is a competitive NAAG peptidase inhibitor (K_i=1 µM) that protects spinal cord neurons from excitotoxicity and hypoxic damage. β-Spaglumic acid is also a selective mGluR3 antagonist (mGluR3 receptor functions to regulate activity-dependent synaptic potentiation in the hippocampus). β-Spaglumic acid can be used in neuroprotection-related studies .

HY-11095

NPS 2390	mGluR CaSR PI3K Akt mTOR Autophagy Apoptosis Bcl-2 Family Caspase	Cardiovascular Disease Neurological Disease
NPS 2390 is an allosteric antagonist of calcium-sensing receptor (CaSR) and mGluR1/5. NPS 2390 inhibits the PI3K/Akt/mTOR signaling pathway, reduces hypoxia-induced intracellular calcium elevation, decreases the expression of autophagy (autophagy) proteins, regulates the expression of phenotypic marker proteins, and inhibits the proliferation of pulmonary artery smooth muscle cells. NPS 2390 attenuates the endogenous apoptosis (apoptosis) pathway, increases the expression level of Bcl-2, downregulates the expression levels of Bax, cytochrome c and caspase-3, alleviates cerebral edema and improves neurological function in rat models. NPS 2390 can be used in studies related to hypoxic pulmonary hypertension, traumatic brain injury, stroke and pain .

HY-103344

ZJ43	Aminopeptidase Carboxypeptidase mGluR	Neurological Disease
ZJ43 is a NAAG peptidase inhibitor and glutamate carboxypeptidase II/III (GCP II/III) inhibitor with human GCP II IC₅₀ of 2.4 nM and K_i of 0.8 nM. ZJ43 blocks N-acetylaspartylglutamate hydrolysis, elevates extracellular N-acetylaspartylglutamate levels, and activates group II metabotropic glutamate receptors (mGluR). ZJ43 can be used for the research of schizophrenia, inflammatory pain, neuropathic pain, and traumatic brain injury .

HY-105181

T 588	nAChR	Neurological Disease
T 588 is an orally active neuroprotective agent. T 588 can increase acetylcholine release from the frontal cortex and hippocampus and meliorate cognitive dysfunction. T 588 can protect cerebellar granule cells from glutamate neurotoxicity. T 588can be used for the research of neurological disease, such as Alzheimer's disease .

HY-117903A

MRT-92	Smo Hedgehog	Cancer
MRT-92 is a Smoothened (Smo) antagonist (K_i=0.7 nM) with anticancer activity. MRT-92 inhibits Hedgehog signaling pathway and rodent cerebellar granule cell proliferation by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor (IC₅₀=0.4 nM). MRT-92 can be used in the study of cerebellar glioma .

HY-W040045R

Callistephin chloride (Standard) Pelargonidin-3-O-glucoside chloride (Standard)	Reference Standards Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK Apoptosis TNF Receptor	Neurological Disease Inflammation/Immunology Cancer
Callistephin (Pelargonidin 3-O-glucoside) chloride (Standard) is the analytical standard of Callistephin chloride (HY-W040045). This product is intended for research and analytical applications. Callistephin chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis.

HY-P1426

AmmTX3	Potassium Channel	Neurological Disease
AmmTX3 is a peptide toxin identified from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is a highly specific blocker of K_v4 channels, which selectively and almost completely blocks transient A-type K ⁺ currents with a K_i of 131 nM. AmmTX3 induces epileptiform behaviors and causes death in mice receiving intracerebroventricular injection. AmmTX3 increases the excitability of dentate gyrus granule cells, reduces GABAergic inhibition, enhances and stabilizes the EPSP-spike component of long-term potentiation, and impairs reference memory. AmmTX3 can be used in research related to pain, epilepsy, and autism spectrum disorder .

HY-117132

YM-202074	mGluR	Neurological Disease
YM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a K_i of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models .

HY-103556

YM-202074 fumarate	mGluR	Neurological Disease
YM-202074 fumarate is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 fumarate binds to the allosteric site of rat mGluR1 with a K_i of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 8.6 nM. YM-202074 fumarate has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models .

HY-100781

D-AP4 D-APB; D-2-Amino-4-phosphonobutyric acid	iGluR	Neurological Disease
D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co ²⁺ influx in cultured cerebellar granule cells (IC₅₀ ≥ 100 μM) .

HY-107510

YM-230888	mGluR	Neurological Disease
YM-230888 is an orally active, selective and allosteric mGlu1 receptor antagonist with a K_i of 13 nM. YM-230888 inhibits mGlu1-mediated inositol phosphate production in rat cerebellar granule cells with an IC₅₀ of 13 nM. YM-230888 shows antinociceptive response in Streptozotocin (HY-13753)-induced hyperalgesia models. YM-230888 significantly reduces pain parameters in complete Freund's adjuvant (HY-153808)-induced arthritic pain models .

HY-15116

ONO 1603	Prolyl Endopeptidase (PREP)	Neurological Disease
ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimer's disease by enhancing cholinergic neurotransmission and neuronal function .

HY-W644305

Androst-16-en-3-ol 3β-Androstenol	GABA Receptor Endogenous Metabolite	Neurological Disease
Androst-16-en-3-ol is a pheromone derived from boars that triggers mating responses in estrous sows. It also exists in human urine, plasma, saliva and sweat. As an endogenous neurosteroid, Androst-16-en-3-ol acts as a positive allosteric modulator of GABA_A receptors (GABA_A receptor) and exerts anxiolytic, antidepressant and anticonvulsant activities in mice.

HY-181811

PJ17	Cholinesterase (ChE) GSK-3	Neurological Disease
PJ17 is a potent dual-target inhibitor of AChE and GSK-3β, with IC₅₀ values of 8.84 μM and 4.19 μM, respectively. PJ17 shows no significant neurotoxic effect in primary cerebellar granule neuron cultures. PJ17 serves as a template for the design of multitarget drugs. PJ17 can be used for the research of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area

HY-P1426

AmmTX3	Potassium Channel	Neurological Disease
AmmTX3 is a peptide toxin identified from the venom of the scorpion Androctonus mauretanicus. AmmTX3 is a highly specific blocker of K_v4 channels, which selectively and almost completely blocks transient A-type K ⁺ currents with a K_i of 131 nM. AmmTX3 induces epileptiform behaviors and causes death in mice receiving intracerebroventricular injection. AmmTX3 increases the excitability of dentate gyrus granule cells, reduces GABAergic inhibition, enhances and stabilizes the EPSP-spike component of long-term potentiation, and impairs reference memory. AmmTX3 can be used in research related to pain, epilepsy, and autism spectrum disorder .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040045

Callistephin chloride 1 Publications Verification Pelargonidin-3-O-glucoside chloride	Anthocyans Flavonoids Classification of Application Fields Rosaceae Other Diseases Phenols Polyphenols Plants Disease Research Fields Fragaria × ananassa Duch. Source Classification	Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK TNF Receptor Apoptosis
Callistephin (Pelargonidin 3-O-glucoside) chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis .

HY-W040045R

Callistephin chloride (Standard) Pelargonidin-3-O-glucoside chloride (Standard)	Anthocyans Flavonoids Rosaceae Phenols Polyphenols Plants Fragaria × ananassa Duch. Source Classification	Reference Standards Reactive Oxygen Species (ROS) COX NO Synthase p38 MAPK Apoptosis TNF Receptor
Callistephin (Pelargonidin 3-O-glucoside) chloride (Standard) is the analytical standard of Callistephin chloride (HY-W040045). This product is intended for research and analytical applications. Callistephin chloride is an anthocyanin. Callistephin chloride regulates the expression of inflammatory (reducing iNOS/TNF-α/COX-2) and apoptosis-related proteins by inhibiting p38 phosphorylation, and enhances the protective effect of Isoflurane (HY-A0134) on microglial cell damage. Callistephin chloride significantly reduces ROS levels, eliminates DPPH free radicals, protects retinal pigment epithelial cells, and inhibits lipid peroxidation. Callistephin chloride can alleviate glutamate excitotoxicity, reduce neuronal apoptosis, and protect cerebellar granule neurons. Callistephin chloride can inhibit the proliferation and metastasis of breast cancer cells by inducing apoptosis.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks