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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
chelation
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "chelation" in MCE Product Catalog:
7
7 Publications Verification
Forschungsgebiete:
Cu(II)-Elesclomol is a complex formed by Elesclomol (HY-12040) and Cu 2+ (copper ions). Cu(II)-Elesclomol is also a weak inhibitor of DNA topoisomerase I. Cu(II)-Elesclomol exerts anticancer effects by inducing oxidative stress and DNA damage through copper chelation. Cu(II)-Elesclomol can inhibit tumor cell proliferation and induce cell cycle arrest and apoptosis. Cu(II)-Elesclomol can be used in the study of cancer .
4
4 Cited Publications
Synonyms: 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
Nitroxoline (8-Hydroxy-5-nitroquinoline), an antibiotic, is an orally active antibiofilm agent. Nitroxoline reduces the formation and induces the dispersal of Pseudomonas aeruginosa biofilms by chelation of iron and zinc. Nitroxoline can be used for the urinary tract infections and cancer research .
4
Target:
4
Target:
Forschungsgebiete:
Ditiocarb sodium (Sodium diethyldithiocarbamate) is an orally active copper reagent. Ditiocarb sodium exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium can be used in the research of tumors, inflammatory, and immune-related diseases .
4
4 Cited Publications
Synonyms: Sodium diethyldithiocarbamate,98%
Target:
Forschungsgebiete:
Ditiocarb sodium,98% (Sodium diethyldithiocarbamate,98%) is an orally active copper reagent. Ditiocarb sodium,98% exhibits activities such as antioxidation, chelation, anti-tumor effects, immunomodulation, and anti-HIV properties. Ditiocarb sodium,98% can be used in the research of tumors, inflammatory, and immune-related diseases .
Art. -Nr.: HY-Y0091
CAS. Nr.: 161265-03-8
Synonyms: 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene
Art. -Nr.: HY-N4084
CAS. Nr.: 271579-11-4
Category:
Thonningia sanguinea Phenols Polyphenols Plants Disease Research Fields Balanophoraceae Cancer
Target:
Art. -Nr.: HY-126404
CAS. Nr.: 65072-00-6
Forschungsgebiete:
Casein hydrolysate is an orally effective, multi-functional mixture of bioactive peptides, a hydrolysis product of casein (HY-125865), containing ACE inhibitors and immunomodulatory target regulators, among others. Casein hydrolysate releases short-chain bioactive peptides through enzymatic hydrolysis of casein, increasing cellular glutathione and catalase levels, enhancing ConA-induced IL-2 production, and exhibiting metal ion chelation, free radical scavenging, antibacterial, and mineral absorption-promoting effects. Casein hydrolysate lowers blood pressure by inhibiting angiotensin-converting enzyme (ACE) and reducing bradykinin degradation .
Category:
Human Gut Microbiota Metabolites Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields
Target:
Art. -Nr.: HY-W110927
CAS. Nr.: 130-22-3
Forschungsgebiete:
DOTA-GA-maleimide is a bifunctional chelator with protein conjugation and radiometal chelation capabilities. DOTA-GA-maleimide forms stable complexes with 111In and conjugates with proteins via maleimide chemistry. DOTA-GA-maleimide conjugates with LFn, enabling 111In radiolabeling of LFn through direct or pre-labeling strategies. Radiolabeled LFn is applicable to MMP activity imaging studies. DOTA-GA-maleimide is used in cancer research .
Art. -Nr.: HY-W035520
CAS. Nr.: 35369-53-0
Art. -Nr.: HY-162386
CAS. Nr.: 324530-92-9
Target:
Forschungsgebiete:
UM4118 is a potent copper-selective non-genotoxic copper ionophore that induces cuproptosis in acute myeloid leukemia cells. UM4118 exhibits stronger activity against SF3B1G12C mutant acute myeloid leukemia cells. UM4118 transports extracellular copper into cells, elevates intracellular and mitochondrial copper levels, and triggers lipoylated DLAT aggregation, proteotoxic stress, iron-sulfur cluster protein depletion, reduced lipoylated protein levels, and maximal mitochondrial respiratory damage. UM4118 cytotoxicity can be enhanced by supplementation with extracellular copper, abolished by copper chelation, and shows synthetic lethal effects in the absence of iron-sulfur cluster biosynthesis/transport genes. UM4118 can be used for the study of acute myeloid leukemia .
Art. -Nr.: HY-W013718
CAS. Nr.: 869-52-3
Art. -Nr.: HY-W041831
CAS. Nr.: 1113-38-8
Synonyms: Ethanedioic acid ammonium
Forschungsgebiete:
Oxalic acid (ammonium) is a oxalic acid bound to ammonium. Oxalic acid has high acidity, reducibility, and chelation ability. Oxalic acid plays important roles in the regulation of plant growth and development, the response to both biotic and abiotic stresses such as plant defense and heavy metals detoxification, and food quality .
Art. -Nr.: HY-W717743
CAS. Nr.: 913528-04-8
Art. -Nr.: HY-B1610K
Art. -Nr.: HY-N2362S2
CAS. Nr.: 53795-94-1
Synonyms: DL-2-Aminopropionic acid-d3
Art. -Nr.: HY-W110896
CAS. Nr.: 2411-89-4
Synonyms: Phthalein Purple
Art. -Nr.: HY-120420
CAS. Nr.: 167695-87-6
Forschungsgebiete:
N4Py is a bleomycin-mimetic pentadentate ligand that targets intracellular FeII and reversibly chelates a variety of transition metals. N4Py chelates induce apoptosis through two pathways: DNA cleavage via ROS generation and XIAP downregulation via ZnII chelation, with only FeII/FeIII-N4Py exhibiting potent DNA cleavage activity. The folate conjugate of N4Py targets folate receptors, can be intracellularly cleaved, and selectively kills FR-positive cancer cells. N4Py can be used in research on various cancers including nasopharyngeal epidermoid carcinoma, ovarian cancer, and mammary adenocarcinoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
