630 Results for "

cytolytic T lymphocytes clone 22/31

" in MedChemExpress (MCE) Product Catalog:
Products (630)

630 Results for "cytolytic T lymphocytes clone 22/31" in MCE Product Catalog:

119
119 Publications Verification
Cat. No.: HY-B0069
CAS No.: 21679-14-1
Synonyms: F-ara-A; NSC 118218
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes .
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107
107 Cited Publications
Cat. No.: HY-13756
CAS No.: 104987-11-3
Purity:  99.93%
Synonyms: FK506; Fujimycin; FR900506
Tacrolimus (FK506), a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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107
107 Cited Publications
Cat. No.: HY-13756A
CAS No.: 109581-93-3
Purity:  99.67%
Synonyms: FK506 monohydrate; Fujimycin monohydrate; FR900506 monohydrate
Tacrolimus (FK506) monohydrate, a molecular glue, a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus monohydrate inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
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68
68 Cited Publications
Cat. No.: HY-18234A
CAS No.: 103476-89-7
Leupeptin hemisulfate is a broad-spectrum protease inhibitor . By inhibiting the activation of the PTEN/PI3K/Akt/NF-κB/ERK1/2/p38 signaling pathway, Leupeptin hemisulfate significantly reduces LPS-induced NO and ROS production, mitochondrial membrane potential hyperpolarization, phagocytic activity, pro-inflammatory cytokine release, and M1 polarization in mouse peritoneal macrophages, and reverses autophagic flux impairment. It also decreases Concanavalin A (HY-P2149)-induced proliferation index of mouse splenic lymphocytes and the Th1/IL-10 and Th2/IL-10 cytokine ratios, thereby modulating innate and adaptive immune responses. Leupeptin hemisulfate inhibits blood coagulation and tumorigenesis in mouse skin. Leupeptin hemisulfate can be used in research on chronic inflammatory diseases and skin tumorigenesis .
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49
49 Cited Publications
Cat. No.: HY-13502
CAS No.: 65271-80-9
Purity:  99.58%
Synonyms: Mitozantrone; NSC 301739
Mitoxantrone is a potent topoisomerase II inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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49
49 Cited Publications
Cat. No.: HY-13502A
CAS No.: 70476-82-3
Purity:  99.55%
Synonyms: Mitozantrone dihydrochloride; NSC 301739 dihydrochloride
Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .
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47
47 Cited Publications
Cat. No.: HY-W010625
CAS No.: 867-55-0
Lithium 2-hydroxypropanoate is a lithium salt. Lithium 2-hydroxypropanoate has immunomodulatory activity (slightly enhancing PHA (HY-N7038)-induced lymphocyte proliferation). Lithium 2-hydroxypropanoate can be used in antioxidant activity assays. Lithium 2-hydroxypropanoate can be used in the research of mental diseases .
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29
29 Cited Publications
Cat. No.: HY-N1724
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B; Folimycin; X 4357B
Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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29
29 Cited Publications
Cat. No.: HY-N1724A
CAS No.: 80890-47-7
Synonyms: Antibiotic X 4357B (purity≥70%); Folimycin (purity≥70%); X 4357B (purity≥70%)
Concanamycin A (purity≥70%) (Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H +-ATPase (V-ATPase) inhibitor. Concanamycin A (purity≥70%) is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research - .
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22
22 Cited Publications
Cat. No.: HY-129905
CAS No.: 6491-83-4
Purity:  98.92%
Synonyms: LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrochloride, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrochloride also can induce endolysosomal pathway stress .
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22
22 Cited Publications
Cat. No.: HY-129905A
CAS No.: 16689-14-8
Purity:  99.69%
Synonyms: LLOMe hydrobromide; Leu-Leu methyl ester hydrobromide; H-Leu-Leu-OMe hydrobromide
L-Leucyl-L-Leucine methyl ester (LLOMe) hydrobromide, a dipeptide condensation product of L-leucine methyl ester generated by human monocytes or polymorphonuclear leukocytes, selectively eliminates lymphocytes with cytotoxic potential. L-Leucyl-L-Leucine methyl ester hydrobromide also can induce endolysosomal pathway stress .
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21
21 Cited Publications
Cat. No.: HY-16209
CAS No.: 284490-13-7
Synonyms: BCX-1777 hydrochloride; Immucillin-H hydrochloride
Research Areas:  

Cancer

Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .
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21
21 Cited Publications
Cat. No.: HY-16210
CAS No.: 209799-67-7
Synonyms: BCX-1777; Immucillin-H
Research Areas:  

Cancer

Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .
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16
16 Cited Publications
Cat. No.: HY-B0078
CAS No.: 4342-03-4
Synonyms: Imidazole Carboxamide
Research Areas:  

Cancer

Dacarbazine is a nonspecific antineoplastic (antineoplastic) alkylating agent. Dacarbazine inhibits T and B lymphocyte responses with IC50 of 50 and 10 μg/mL, respectively. Dacarbazine can be used in the study of metastatic malignant melanoma .
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16
16 Cited Publications
Cat. No.: HY-N0637
CAS No.: 552-58-9
Synonyms: Huazhongilexone
Eriodictyol ((±)-Huazhongilexone; Dihydroluteolin) is an orally active TRPV1 receptor antagonist (IC50=44-47 nM, rTRPV1) with antioxidant and anti-inflammatory activities. Eriodictyol effectively inhibits lipid peroxidation and the release of proinflammatory cytokines by specifically antagonizing the TRPV1 receptor and activating the Nrf2 signaling pathway. Eriodictyol reduces the levels of ICAM-1, VEGF, eNOS and TNF-α in the retina and maintains the integrity of the blood-retinal barrier. Eriodictyol alleviates oxidative stress-induced apoptosis and hyperalgesia, enhances the activity and cytotoxicity of immune cells (such as B lymphocytes, NK cells and macrophages), and increases the levels of antioxidant enzymes simultaneously. Eriodictyol can be used in the research of diabetic retinopathy, acute lung injury and various pain-related diseases .
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14
14 Cited Publications
Cat. No.: HY-B0199A
CAS No.: 116680-01-4
Synonyms: RS 61443 hydrochloride; TM-MMF hydrochloride
Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection) .
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14
14 Cited Publications
Cat. No.: HY-B0199
CAS No.: 128794-94-5
Synonyms: RS 61443; TM-MMF
Mycophenolate mofetil (RS 61443) is the morpholinoethylester proagent of Mycophenolic acid. Mycophenolate mofetil inhibits de novo purine synthesis via the inhibition of inosine monophosphate dehydrogenase (IMPDH). Mycophenolate mofetil shows selective lymphocyte antiproliferative effects involve both T and B cells, preventing antibody formation .
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12
12 Cited Publications
Cat. No.: HY-19344
CAS No.: 1025967-78-5
Synonyms: SAR 1118; SHP-606
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Lifitegrast (SAR 1118) is a potent integrin antagonist. Lifitegrast blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast can be used for researching dry eye disease .
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12
12 Cited Publications
Cat. No.: HY-19344A
CAS No.: 1119276-80-0
Synonyms: SAR 1118 sodium; SHP-606 sodium
Target:  

Integrin

Research Areas:  

Inflammation/Immunology

Lifitegrast (SAR 1118) sodium is a potent integrin antagonist. Lifitegrast sodium blocks the binding of intercellular adhesion molecule 1 (ICAM-1) to lymphocyte function-associated antigen 1 (LFA-1), interrupting the T cell-mediated inflammatory cycle. Lifitegrast sodium inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM. Lifitegrast sodium can be used for researching dry eye disease .
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11
11 Cited Publications
Cat. No.: HY-B1777
CAS No.: 71-44-3
Synonyms: NSC 268508; Neuridine
Spermine is a natural antioxidant and anti-inflammatory agent. Spermine is known to inhibit some bacterial cultures, especially strains of Staphylococcus aureus. Spermine can reversibly inhibits DNA synthetic response, mixed lymphocyte response and the induction of cytolytic lymphocyte response in primary cultures of murine spleen cells. Spermine is a polyamine nitric oxide donor that can provide nitric oxide to platelets and inhibit platelet activation to a certain extent concentration-dependently. Spermine occurs in mammalian tissues, plants, bacteria, ribosomes and bacteriophage. Spermine inhibits primary human embryo lung fibroblasts in vitro .
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