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Results for "

dGTP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (5) Biochemical Assay Reagents (14) DNA Stain (1) DNA/RNA Synthesis (18) Drug Derivative (1) Endogenous Metabolite (1) Fluorescent Dye (1) HIV (4) Isotope-Labeled Compounds (5) Nucleoside Antimetabolite/Analog (21) Ras (1) Reverse Transcriptase (2) Telomerase (2)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (12) Inflammation/Immunology (2) Metabolic Disease (5) Neurological Disease (2)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Azide (3)
Oligonucleotides:	Guanine Nucleotide (2) Nucleoside Analogs (4) Nucleotide Analogs (9)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16210

Forodesine Maximum Cited Publications 20 Publications Verification BCX-1777; Immucillin-H	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-16209

Forodesine hydrochloride Maximum Cited Publications 20 Publications Verification BCX-1777 hydrochloride; Immucillin-H hydrochloride	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-W008661

Deoxyguanosine triphosphate trisodium solution (100 mM) 1 Publications Verification dGTP trisodium solution (100 mM); 2'-Deoxyguanosine-5'-triphosphate trisodium solution (100 mM)	DNA/RNA Synthesis	Others
Deoxyguanosine triphosphate (dGTP) trisodium solution (100 mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-170224

dNTP Mixture,10 mM Solution,PCR Grade	Biochemical Assay Reagents	Others
dNTP Mixture,10 mM Solution,PCR Grade is a PCR-grade 10 mM mixed solution of natural deoxynucleoside triphosphates (dATP, dCTP, dGTP, TTP), which is suitable for various biological reactions including DNA amplification and reverse transcription .

HY-D1668

Biotin-11-dCTP	DNA Stain Reverse Transcriptase	Infection Neurological Disease Cancer
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of *dGTP* and avian myeloblastosis virus reverse transcriptase .

HY-138616

*dGTP* 2'-Deoxyguanosine-5'-triphosphate	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Inflammation/Immunology
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP .

HY-144661

KRAS G12D inhibitor 14	Ras Apoptosis	Cancer
KRAS G12D inhibitor 14 is a potent KRAS G12D inhibitor with a K_D of 33 nM for binding to KRAS G12D protein. KRAS G12D inhibitor 14 decreases the active form of KRAS G12D (KRAS G12D-GTP) but not KRAS G13D .

HY-112817

8-Oxo-dGTP 8-Oxo-Deoxyguanosine triphosphate	Apoptosis	Cardiovascular Disease Neurological Disease Cancer
8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .

HY-158674

*3'-P-dGTP* sodium,100 mM Solution**	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3'-P-dGTP sodium,100 mM Solution is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-158713

*3'-ONH2-dGTP* sodium solution (100 mM)**	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3'-ONH2-dGTP sodium solution (100 mM) is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-138616S3

dGTP-13C10 dilithium 2'-Deoxyguanosine-5'-triphosphate-13C10 dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-W008661A

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade	DNA/RNA Synthesis	Others
Deoxyguanosine triphosphate (dGTP) trisodium,100 mM Solution,PCR Grade is one of the raw materials used by DNA polymerases to synthesize long DNA strands during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied in the form of an aqueous solution .

HY-142028A

Acyclovir triphosphate sodium (100 mM) AcycloGTP sodium (100 mM)	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog HIV Reverse Transcriptase	Infection
Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate (sodium) (100 mM) is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate (sodium) (100 mM) causes termination of viral DNA synthesis .

HY-W013715B

Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade dTTP trisodium,100 mM Solution,PCR Grade	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Endogenous Metabolite	Others
Deoxythymidine-5'-triphosphate (dTTP) trisodium, 100 mM Solution, PCR Grade is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate trisodium, 100 mM Solution, PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.

HY-138616S4

dGTP-13C10,15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-13C10,15N5 dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-15349

Trovirdine 1 Publications Verification LY300046	HIV	Infection
Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.

HY-157221

*Biotin-16-dGTP* tetralithium**	Nucleoside Antimetabolite/Analog	Others
Biotin-16-dGTP tetralithium is a Biotin labeled dGTP, and can be used to label oligonucleotides .

HY-W250161

7-Deaza-2′-deoxyguanosine 5′-triphosphate 7-Deaza-2'-dGTP	Telomerase	Cancer
7-Deaza-2′-deoxyguanosine 5′-triphosphate (7-Deaza-2'-dGTP), a nucleotide analogue, is a telomerase inhibitor (IC₅₀: 11 μM) .

HY-175103

Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate sodium β-L-dGTP sodium; L-2'-Deoxyguanosine 5'-triphosphate sodium; 2’-Deoxy-L-GTP sodium	Telomerase	Others
Guanine-2'-deoxy-β-L-ribofuranosyl-5'-O-triphosphate (sodium) is an isomer of dGTP and an inhibitor of telomerase with a K_i of 15 μM for human enzyme .

HY-170238

dNTP Mixture,25 mM Solution,PCR Grade	Biochemical Assay Reagents	Others
dNTP Mixture,25 mM Solution,PCR Grade is a PCR-grade 25 mM mixed solution of natural deoxynucleoside triphosphates (dATP, dCTP, dGTP, TTP), which is suitable for various biological reactions including DNA amplification and reverse transcription .

HY-15353

Emivirine MKC-442	HIV	Infection Inflammation/Immunology
Emivirine (MKC-442) is a non-nucleoside reverse transcriptase inhibitors (NNRTIs) with K_i values of 0.20 and 0.01 μM for dTTP- and dGTP-dependent DNA or RNA polymerase activity, respectively. Emivirine displays potent and selective anti-human immunodeficiency virus type 1 (HIV-1) activity .

HY-132144A

*7-Deaza-7-propargylamino-dGTP* sodium**	Biochemical Assay Reagents	Others
7-Deaza-7-propargylamino-dGTP sodium is the sodium salt form of 7-Deaza-7-propargylamino-dGTP (HY-132144). 7-Deaza-7-propargylamino-dGTP sodium is an analog of deoxyguanosine triphosphate dGTP (HY-W008661) and can be used for gene sequencing .

HY-132144

7-Deaza-7-propargylamino-dGTP	Biochemical Assay Reagents	Others
7-Deaza-7-propargylamino-dGTP is an analog of deoxyguanosine triphosphate (dGTP) that can be used for gene sequencing .

HY-158666

*3'-Amino-3'-dGTP* sodium**	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3'-Amino-3'-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-132140

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP	Biochemical Assay Reagents	Others
7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is an analog of deoxyguanosine triphosphate (dGTP) that widely used in the next generation sequencing (NGS) .

HY-157001

*7-Deaza-dGTP* tetralithium**	Biochemical Assay Reagents	Others
7-Deaza-dGTP tetralithium can be used for amplification of GC-rich DNA sequences .

HY-138616S1

dGTP-d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-d14 dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-W894385B

*3'-Azidomethyi-dGTP* sodium**	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3'-Azidomethyi-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-132140A

*7-Deaza-7-propargylamino-3'-azidomethyl-dGTP* triethylamine**	Biochemical Assay Reagents	Others
7-Deaza-7-propargylamino-3'-azidomethyl-dGTP triethylamine is an analog of deoxyguanosine triphosphate (dGTP) that widely used in the next generation sequencing (NGS) .

HY-138616S

dGTP-15N5 dilithium 2'-Deoxyguanosine-5'-triphosphate-15N5 dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-158718

*3'-O-Methylthiomethyl-dGTP* sodium**	Biochemical Assay Reagents DNA/RNA Synthesis	Others
3'-O-Methylthiomethyl-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-138616S2

dGTP-15N5,d14 dilithium 2'-Deoxyguanosine-5'-triphosphate-15N5,d14 dilithium	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog	Infection Cancer
dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-134273A

*8-Br-dGTP* sodium** 8-Bromo-dGTP sodium	Nucleoside Antimetabolite/Analog	Others
8-Br-dGTP (8-Bromo-dGTP) sodium (Compound 5), an 8-brominated purine nucleotide, is a syn-oriented analog of dGTP. 8-Br-dGTP sodium can be hydrolyzed by the enzyme hMTH1 protein (HY-P74740). 8-Br-dGTP sodium inhibits dGTP-activated ADP reduction with a K_i of 56  μM. 8-Br-dGTP sodium has no significant genotoxicity and mutagenic potentials during DNA synthesis .

HY-137618A

Sp-dGTPαS tetrasodium	Nucleoside Antimetabolite/Analog	Infection
Sp-dGTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dGTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a K_i of 820 nM .

HY-137618

Sp-dGTPαS	Biochemical Assay Reagents	Others
Sp-dGDPαS is a regulator of GDP-binding proteins. Sp-dGDPαS is metabolically more stable than GTP .

HY-137618B

Rp-dGTPαS	HIV	Others
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates .

HY-W784575A

dGTPαS sodium 2'-Deoxyguanosine-5'-O-(α-thio)triphosphate sodium	Biochemical Assay Reagents DNA/RNA Synthesis	Others
dGTPαS sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-137619A

Sp-dCTPαS tetrasodium	Nucleoside Antimetabolite/Analog	Infection
Sp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616). Sp-dCTPαS tetrasodium inhibits SAMHD1 triphosphohydrolase activity with a K_i of 6.3 μM .

HY-D3310

Fluorescein-12-dGTP	Fluorescent Dye	Others
Fluorescein-12-dGTP is a fluorescein-labeled deoxyguanosine triphosphate. Fluorescein-12-dGTP incorporates into complementary allele-specific primers at SNP sites, enabling FRET with cationic conjugated polymer PFP via DNA-PFP electrostatic interactions. Fluorescein-12-dGTP incorporates into G-allele-specific primers for homozygous G/G SNP genotypes to enable genotype discrimination. Fluorescein-12-dGTP serves as a fluorescently labeled nucleotide for homogeneous solution-based SNP and FRET genotyping assays (Ex/Em = 498/517 nm) .

HY-178533

3'-ONH2-dGTP	Nucleoside Antimetabolite/Analog	Metabolic Disease
3'-ONH2-dGTP is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W894385

3'-Azidomethyi-dGTP	Nucleoside Antimetabolite/Analog	Metabolic Disease
3'-Azidomethyi-dGTP is a monomeric raw material that can be used for nucleic acid synthesis.

HY-185481

3'-O-Allyl-dGTP	Nucleoside Antimetabolite/Analog	Others
3'-O-Allyl-dGTP is a nucleotide analog that can be used for oligonucleotide synthesis.

HY-185273

3'-O-(2-Nitrobenzyl)-dGTP	DNA/RNA Synthesis	Others
3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .

HY-131805A

*3'-O-Ac-dGTP* sodium**	Drug Derivative	Metabolic Disease
3'-O-Ac-dGTP sodium is an acetylated derivative of the nucleoside triphosphate 2'-deoxyguanosine-5'-triphosphate .

HY-112817A

*8-Oxo-dGTP* trisodium solution (100 mM)** 8-Oxo-Deoxyguanosine triphosphate trisodium	Apoptosis	Others
8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) trisodium solution (100mM) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP trisodium solution (100mM) acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP trisodium solution (100mM) causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP trisodium solution (100mM) in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP trisodium solution (100mM) is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .

HY-176826

*3'-Bromo ANT-dGTP* sodium salt** 3'-O-(5-Bromoanthraniloyl)-2'-deoxyguanosine-5'-O-triphosphate sodium salt	Nucleoside Antimetabolite/Analog	Others
3'-Bromo ANT-dGTP (3'-O-(5-Bromoanthraniloyl)-2'-deoxyguanosine-5'-O-triphosphate) sodium is a derivative of dGTP (HY-138616) .

HY-134032

2'-Deoxy-2'-fluoroguanosine-5'-triphosphate 2'-F-dGTP	Nucleoside Antimetabolite/Analog	Metabolic Disease
2'-Deoxy-2'-fluoroguanosine-5'-triphosphate (2'-F-dGTP) is a monomeric raw material that can be used for nucleic acid synthesis.

HY-137619C

Rp-dCTPαS tetrasodium	Nucleoside Antimetabolite/Analog	Infection
Rp-dCTPαS tetrasodium is a sulfur-containing isomer of dGTP (HY-138616) .

HY-W784575

dGTPαS 2'-Deoxyguanosine-5'-O-(α-thio)triphosphate	Nucleoside Antimetabolite/Analog	Metabolic Disease
dGTPαS (2'-Deoxyguanosine-5'-O-(α-thio)triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.

HY-123599

IACS-4619	DNA/RNA Synthesis	Cancer
IACS-4619 (compound 4) is a highly selective 2-aminopyrimidine-based MTH1 (MutT homolog 1) inhibitor (IC₅₀=0.2 nM). IACS-4619 inhibits MTH1 by blocking its hydrolysis of oxidized purine nucleotides such as *8-oxo-dGTP*, thereby preventing MTH1 from inhibiting the incorporation of oxidized nucleotides into DNA. IACS-4619 significantly inhibits endogenous MTH1 activity in MTH1-overexpressing U2OS cells, but without antiproliferative or cytotoxic effects on various human cancer and normal cell lines. IACS-4619 can be used in oncology research related to the MTH1 target .

Cat. No.	Product Name	Type

HY-D1668

Biotin-11-dCTP

Fluorescent Dye

Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of dGTP and avian myeloblastosis virus reverse transcriptase .

HY-D3310

Fluorescein-12-dGTP

Fluorescent Dye

Fluorescein-12-dGTP is a fluorescein-labeled deoxyguanosine triphosphate. Fluorescein-12-dGTP incorporates into complementary allele-specific primers at SNP sites, enabling FRET with cationic conjugated polymer PFP via DNA-PFP electrostatic interactions. Fluorescein-12-dGTP incorporates into G-allele-specific primers for homozygous G/G SNP genotypes to enable genotype discrimination. Fluorescein-12-dGTP serves as a fluorescently labeled nucleotide for homogeneous solution-based SNP and FRET genotyping assays (Ex/Em = 498/517 nm) .

Cat. No.	Product Name	Type

HY-W008661

Deoxyguanosine triphosphate trisodium solution (100 mM) 1 Publications Verification dGTP trisodium solution (100 mM); 2'-Deoxyguanosine-5'-triphosphate trisodium solution (100 mM)	Biochemical Assay Reagents
Deoxyguanosine triphosphate (dGTP) trisodium solution (100 mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-170224

dNTP Mixture,10 mM Solution,PCR Grade	Biochemical Assay Reagents
dNTP Mixture,10 mM Solution,PCR Grade is a PCR-grade 10 mM mixed solution of natural deoxynucleoside triphosphates (dATP, dCTP, dGTP, TTP), which is suitable for various biological reactions including DNA amplification and reverse transcription .

HY-158674

*3'-P-dGTP* sodium,100 mM Solution**	Biochemical Assay Reagents
3'-P-dGTP sodium,100 mM Solution is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-158713

*3'-ONH2-dGTP* sodium solution (100 mM)**	Biochemical Assay Reagents
3'-ONH2-dGTP sodium solution (100 mM) is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-W008661A

Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade dGTP trisodium,100 mM Solution,PCR Grade; 2'-Deoxyguanosine-5'-triphosphate trisodium,100 mM Solution,PCR Grade	Biochemical Assay Reagents
Deoxyguanosine triphosphate (dGTP) trisodium,100 mM Solution,PCR Grade is one of the raw materials used by DNA polymerases to synthesize long DNA strands during DNA replication. Deoxyguanosine triphosphate trisodium,100 mM Solution,PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied in the form of an aqueous solution .

HY-142028A

Acyclovir triphosphate sodium (100 mM) AcycloGTP sodium (100 mM)	Biochemical Assay Reagents
Acyclovir triphosphate (Synonyms: AcycloGTP) sodium is a Acyclovir (HY-17422) derivative that competitively inhibits viral DNA polymerase by acting as an analog to deoxyguanosine triphosphate (dGTP). Acyclovir triphosphate (sodium) (100 mM) is an inhibitor of HIV-1 reverse transcriptase. Acyclovir triphosphate (sodium) (100 mM) causes termination of viral DNA synthesis .

HY-W013715B

Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade dTTP trisodium,100 mM Solution,PCR Grade	Biochemical Assay Reagents
Deoxythymidine-5'-triphosphate (dTTP) trisodium, 100 mM Solution, PCR Grade is one of the raw materials used by DNA polymerase to synthesize long DNA strands during DNA replication. Deoxythymidine-5'-triphosphate trisodium, 100 mM Solution, PCR Grade is used in polymerase chain reaction (PCR) for DNA amplification. This product is supplied as an aqueous solution.

HY-170238

dNTP Mixture,25 mM Solution,PCR Grade	Biochemical Assay Reagents
dNTP Mixture,25 mM Solution,PCR Grade is a PCR-grade 25 mM mixed solution of natural deoxynucleoside triphosphates (dATP, dCTP, dGTP, TTP), which is suitable for various biological reactions including DNA amplification and reverse transcription .

HY-132144A

*7-Deaza-7-propargylamino-dGTP* sodium**	Biochemical Assay Reagents
7-Deaza-7-propargylamino-dGTP sodium is the sodium salt form of 7-Deaza-7-propargylamino-dGTP (HY-132144). 7-Deaza-7-propargylamino-dGTP sodium is an analog of deoxyguanosine triphosphate dGTP (HY-W008661) and can be used for gene sequencing .

HY-132144

7-Deaza-7-propargylamino-dGTP	Biochemical Assay Reagents
7-Deaza-7-propargylamino-dGTP is an analog of deoxyguanosine triphosphate (dGTP) that can be used for gene sequencing .

HY-158666

*3'-Amino-3'-dGTP* sodium**	Biochemical Assay Reagents
3'-Amino-3'-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-132140

7-Deaza-7-propargylamino-3'-azidomethyl-dGTP	Biochemical Assay Reagents
7-Deaza-7-propargylamino-3'-azidomethyl-dGTP is an analog of deoxyguanosine triphosphate (dGTP) that widely used in the next generation sequencing (NGS) .

HY-W894385B

*3'-Azidomethyi-dGTP* sodium**	Biochemical Assay Reagents
3'-Azidomethyi-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-158718

*3'-O-Methylthiomethyl-dGTP* sodium**	Biochemical Assay Reagents
3'-O-Methylthiomethyl-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-W784575A

dGTPαS sodium 2'-Deoxyguanosine-5'-O-(α-thio)triphosphate sodium	Biochemical Assay Reagents
dGTPαS sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-138616

*dGTP* 2'-Deoxyguanosine-5'-triphosphate	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP .

HY-112817

8-Oxo-dGTP 8-Oxo-Deoxyguanosine triphosphate	Microorganisms Source Classification	Apoptosis
8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71482

	MutT Protein, E.coli (His-SUMO) mutT; b0099; JW0097; 8-oxo-dGTP diphosphatase; 8-oxo-dGTPase; EC 3.6.1.55; 7,8-dihydro-8-oxoguanine-triphosphatase; Mutator protein MutT; dGTP pyrophosphohydrolase	E.coli	E. coli
	The MutT protein maintains the genome by hydrolyzing 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to their corresponding monophosphates. Integrity plays a key role. This prevents misincorporation of 8-oxoGua into DNA and RNA, ensuring the fidelity of the nucleotide library. MutT Protein, E.coli (His-SUMO) is the recombinant E. coli-derived MutT protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-138616S3

dGTP-13C10 dilithium
dGTP- ¹³C₁₀ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀) dilithium is ¹³C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S4

dGTP-13C10,15N5 dilithium

dGTP- ¹³C₁₀, ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹³C₁₀, ¹⁵N₅) dilithium is ¹³C and ¹⁵N-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S1

dGTP-d14 dilithium
dGTP-d₁₄ (2'-Deoxyguanosine-5'-triphosphate-d₁₄) dilithium is deuterium labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S

dGTP-15N5 dilithium
dGTP- ¹⁵N₅ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅) dilithium is ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

HY-138616S2

dGTP-15N5,d14 dilithium

dGTP- ¹⁵N₅,d₁₄ (2'-Deoxyguanosine-5'-triphosphate- ¹⁵N₅,d₁₄) dilithium is deuterium and ¹⁵N labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

Cat. No.	Product Name		Classification

HY-D1668

Biotin-11-dCTP		Labeling and Fluorescence Imaging
Biotin-11-dCTP is a biotinylated deoxynucleoside triphosphate and an important DNA labeling reagent. In random primer DNA labeling reactions, Biotin-11-dCTP incorporates into newly synthesized DNA strands to generate labeled DNA probes suitable for hybridization applications. In addition, Biotin-11-dCTP can serve as a substrate for terminal deoxynucleotidyl transferase to end-label oligonucleotides for telomere sequence detection, or to label the cut ends of linearized DNA molecules, thereby supporting streptavidin-based electron microscopy analysis. For example, Biotin-11-dCTP can label the cut ends of linearized DNA molecules under the action of *dGTP* and avian myeloblastosis virus reverse transcriptase .

HY-W894385B

*3'-Azidomethyi-dGTP* sodium**		Azide
3'-Azidomethyi-dGTP sodium is a labeled modified deoxyoligonucleotide (dNTP) that can release pyrophosphate to produce fluorescence and has special applications in gene synthesis and sequencing .

HY-132140A

*7-Deaza-7-propargylamino-3'-azidomethyl-dGTP* triethylamine**		Azide
7-Deaza-7-propargylamino-3'-azidomethyl-dGTP triethylamine is an analog of deoxyguanosine triphosphate (dGTP) that widely used in the next generation sequencing (NGS) .

HY-W894385

3'-Azidomethyi-dGTP		Azide
3'-Azidomethyi-dGTP is a monomeric raw material that can be used for nucleic acid synthesis.

Cat. No.	Product Name		Classification

HY-W008661

Deoxyguanosine triphosphate trisodium solution (100 mM) 1 Publications Verification dGTP trisodium solution (100 mM); 2'-Deoxyguanosine-5'-triphosphate trisodium solution (100 mM)		Nucleotide Analogs
Deoxyguanosine triphosphate (dGTP) trisodium solution (100 mM) is a nucleotide precursor in cells for DNA synthesis. Deoxyguanosine triphosphate trisodium salt is used in reverse transcription-polymerase chain reaction (RT-PCR) for DNA amplification .

HY-138616

*dGTP* 2'-Deoxyguanosine-5'-triphosphate		Nucleotide Analogs
dGTP (2'-Deoxyguanosine-5'-triphosphate) is one of the precursors for DNA synthesis, and serves as a direct substrate for DNA replication and repair. dGTP is prone to oxidative damage; under the action of reactive oxygen species and other factors, dGTP is oxidized to form 8-oxo-dGTP .

HY-132140A

*7-Deaza-7-propargylamino-3'-azidomethyl-dGTP* triethylamine**		Nucleotide Analogs
7-Deaza-7-propargylamino-3'-azidomethyl-dGTP triethylamine is an analog of deoxyguanosine triphosphate (dGTP) that widely used in the next generation sequencing (NGS) .

HY-178533

3'-ONH2-dGTP		Nucleoside Analogs Nucleotide Analogs
3'-ONH2-dGTP is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W894385

3'-Azidomethyi-dGTP		Nucleoside Analogs Nucleotide Analogs
3'-Azidomethyi-dGTP is a monomeric raw material that can be used for nucleic acid synthesis.

HY-185273

3'-O-(2-Nitrobenzyl)-dGTP		Nucleotide Analogs Guanine Nucleotide
3'-O-(2-Nitrobenzyl)-dGTP is a reversible terminator. 3'-O-(2-Nitrobenzyl)-dGTP can be recognized and incorporated by DNA polymerases, thereby temporarily terminating DNA primer extension; after the 2-nitrobenzyl blocking group is removed via laser irradiation, a free 3'-OH can be regenerated to allow subsequent polymerase-mediated extension. 3'-O-(2-Nitrobenzyl)-dGTP can be used in DNA sequencing studies .

HY-112817A

*8-Oxo-dGTP* trisodium solution (100 mM)** 8-Oxo-Deoxyguanosine triphosphate trisodium		Nucleotide Analogs Guanine Nucleotide
8-Oxo-dGTP (8-Oxo-Deoxyguanosine triphosphate) trisodium solution (100mM) is an oxidized guanine nucleotide formed by ROS-mediated oxidative modification of dGTP, and it also serves as a key substrate for 8-oxo-dGTP pyrophosphohydrolases (such as hMTH1 and E. coli MutT). 8-Oxo-dGTP trisodium solution (100mM) acts as a DNA mutagen, inserts into nascent DNA and pairs with adenine and cytosine, inducing A:T to C:G transversion mutations. Furthermore, 8-Oxo-dGTP trisodium solution (100mM) causes oxidative DNA base modification, strand breakage and S-phase arrest, and ultimately triggers AIF-mediated apoptosis and promotes spontaneous carcinogenesis in mth1-deficient mice. Accumulation of 8-Oxo-dGTP trisodium solution (100mM) in cells induces genomic instability, but it exhibits a tumor-suppressive effect that reduces tumor incidence in mouse models instead. 8-Oxo-dGTP trisodium solution (100mM) is widely used in studies related to spontaneous carcinogenesis, Parkinson's disease, Alzheimer's disease, heart failure and tumor mechanisms .

HY-134032

2'-Deoxy-2'-fluoroguanosine-5'-triphosphate 2'-F-dGTP		Nucleoside Analogs Nucleotide Analogs
2'-Deoxy-2'-fluoroguanosine-5'-triphosphate (2'-F-dGTP) is a monomeric raw material that can be used for nucleic acid synthesis.

HY-W784575

dGTPαS 2'-Deoxyguanosine-5'-O-(α-thio)triphosphate		Nucleoside Analogs Nucleotide Analogs
dGTPαS (2'-Deoxyguanosine-5'-O-(α-thio)triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.

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