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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
intestinal stability
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "intestinal stability" in MCE Product Catalog:
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1 Cited Publications
Cat. No.: HY-W127512
CAS No.: 546-18-9
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5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
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Flavonols Flavonoids Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer Myrtaceae Extract
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Category:
Other disease Metabolic Disease Endogenous metabolite Human Gut Microbiota Metabolites Flavonoids Isoflavanones Disease markers Phenols Polyphenols Disease Research Fields
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Cat. No.: HY-170704
CAS No.: 1480940-53-1
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DSPE-PEG2000-TCO is a click chemistry coupling partner. DSPE-PEG2000-TCO undergoes a reverse electron-demand Diels-Alder click reaction to form a covalent linkage with tetrazine-modified Cetuximab (HY-P9905). DSPE-PEG2000-TCO maintains the stability of lipid nanoparticles (LNPs) and has high mRNA encapsulation efficiency, which supports cellular uptake and mRNA transfection. DSPE-PEG2000-TCO is used to prepare EGFR-targeted and APN-targeted mRNA-loaded LNPs, mediating receptor-dependent endocytosis, mRNA delivery, and intestinal epithelial transcytosis .
Cat. No.: HY-N7541
CAS No.: 656830-24-9
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Cat. No.: HY-125356
CAS No.: 2209871-83-8
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ETX0282 is an orally active prodrug, with its active form being ETX1317. ETX0282 and ETX1317 are β-lactamase inhibitors of the dioxolane-dibenzo-p-heptane (DBO) type. ETX0282 exhibits high stability during intestinal absorption and can be efficiently converted into ETX1317 in the liver. ETX0282 alone has no bactericidal activity, but in a mouse model of neutropenic thigh infection, it can significantly reduce bacterial load when used in combination with Cefpodoxime Proxetil (HY-N7101). ETX0282 can be used for the study of infections caused by drug-resistant Gram-negative bacteria .
Cat. No.: HY-P5520
CAS No.: 2413262-74-3
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Cat. No.: HY-152614
CAS No.: 2897630-89-4
Antimalarial agent 19 (compound 6e) is an antimalarial active agent. Antimalarial agent 19 has antimalarial activity for the blood stage of P. falciparum K1 and P. berghei with EC50 values of 0.3 µM, 15.3 µM, respectively. Antimalarial agent 19 has good aqueous solubility, intestinal permeability and microsomal stability compared to gamhepathiopine .
Cat. No.: HY-N1461R
CAS No.: 17238-05-0
Synonyms: (±)-Dihydrodaidzein (Standard)
Cat. No.: HY-189666
CAS No.: 3101978-77-9
KRAS-IN-65 is an orally active KRAS inhibitor. KRAS-IN-65 inhibits KRAS G12D/G12V signaling with IC50 values of 20 nM and 5 nM, respectively. KRAS-IN-65 exhibits reduced glucuronidation and intestinal stability. KRAS-IN-65 produces limited tumor growth inhibition in xenograft models. KRAS-IN-65 can be used for cancer-related research, such as non-small cell lung cancer and colorectal cancer .
Cat. No.: HY-W127512R
CAS No.: 546-18-9
Target:
Research Areas:
5β-Cholanic acid is a hydrophobic modifier used to modify polymer carriers. 5β-Cholanic acid can improve the acid stability, cell penetration efficiency and drug sustained release ability of nanocarriers, and optimize the oral effectiveness of delivered molecules. 5β-Cholanic acid can covalently bind to Glycol chitosan (GC) to form a GC-CA conjugate, which optimizes the hydrophobic anchoring ability of nanoparticles and enables them to be stably adsorbed on the surface of PLGA nanoparticles. Such nanoparticles can resist dissociation in the gastric acid environment and maintain positive charge to enhance endocytic uptake by intestinal epithelial cells (such as Caco-2 cells). 5β-Cholanic acid can be used in the development of drug delivery systems .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
