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movement

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5

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16926
    CK-666
    Maximum Cited Publications
    25 Publications Verification

    Arp2/3 Complex HIV Infection Cancer
    CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC50=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation .
    CK-666
  • HY-109012
    Seltorexant
    3 Publications Verification

    JNJ-42847922

    Orexin Receptor (OX Receptor) Neurological Disease Endocrinology
    Seltorexant (JNJ-42847922) is an orally active, high-affinity, and selective orexin-2 receptor (OX2R) antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
    Seltorexant
  • HY-N2549

    (±)-ABA

    Calcium Channel Metabolic Disease Inflammation/Immunology
    (±)-Abscisic acid is an orally active plant hormone that is present also in animals. (±)-Abscisic acid (ABA) contributes to the regulation of glycemia in mammals .
    (±)-Abscisic acid
  • HY-109139
    Taminadenant
    1 Publications Verification

    NIR178; PBF509

    Adenosine Receptor Neurological Disease Cancer
    Taminadenant (NIR178; PBF509) is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response .
    Taminadenant
  • HY-B1277
    Trihexyphenidyl hydrochloride
    3 Publications Verification

    mAChR Cholinesterase (ChE) Neurological Disease
    Trihexyphenidyl hydrochloride is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl hydrochloride modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl hydrochloride improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl hydrochloride can be used for the research of Parkinson's disease. .
    Trihexyphenidyl hydrochloride
  • HY-D1727
    CellTracker Red CMTPX
    2 Publications Verification

    Fluorescent Dye Others
    CellTracker Red CMTPX is a cell-permeable fluorescent dye that can be used as a cell tracer for monitoring cell movement and location (Ex/Em=586/614 nm) .
    CellTracker Red CMTPX
  • HY-109160
    Rimtuzalcap
    2 Publications Verification

    CAD-1883

    Potassium Channel Neurological Disease
    Rimtuzalcap (CAD-1883) is a first-in-class selective positive allosteric modulator of small-conductance calcium-activated potassium channels (SK channels). Rimtuzalcap can be used for the research of movement disorders including essential tremor (ET) and spinocerebellar ataxia (SCA) .
    Rimtuzalcap
  • HY-B0557
    Bisacodyl
    2 Publications Verification

    Dopamine Transporter Opioid Receptor Metabolic Disease Cancer
    Bisacodyl is a stimulant laxative agent that works directly on the colon to produce a bowel movement. Bisacodyl increases the secretion of PGE2 by direct activation of colon macrophages. PGE2 acts as a paracrine factor and decreases the expression of AQP3 in the colon, which inhibits water transfer from the luminal to the vascular side and leads to a laxative effect .
    Bisacodyl
  • HY-P0102

    nAChR Neurological Disease Metabolic Disease
    Dipeptide diaminobutyroyl benzylamide diacetate, a Wagerlin-1-mimicking peptide, is a nAChR antagonist. Dipeptide diaminobutyroyl benzylamide diacetate mimics Waglerin-1 to block neuromuscular junction nicotinic acetylcholine receptors, partially inhibits neuronal signal transduction, and relaxes muscles. Dipeptide diaminobutyroyl benzylamide diacetate reduces appearance of facial wrinkles linked to repeated muscle movement.Dipeptide diaminobutyroyl benzylamide diacetate can be used for the research of mild-to-moderate fine and coarse periocular and perioral wrinkles and periorbital ageing .
    Dipeptide diaminobutyroyl benzylamide diacetate
  • HY-D2865

    Fluorescent Dye Others
    Celltrack Deep Red is a fluorescent dye with a fluorescence signal that can be maintained for at least 72 h and has good stability. Celltrack Deep Red can be used for cell tracing and multi-generation cell movement tracking. Within a cell population, Celltrack Deep Red is only transferred to daughter cells and not to neighboring cells (Ex/Em = 630/650 nm) .
    Celltrack Deep Red
  • HY-119486
    Tavapadon
    2 Publications Verification

    PF-06649751; CVL-751

    Dopamine Receptor Neurological Disease
    Tavapadon (PF-06649751) is an orally active and highly selective dopamine D1/D5 receptor partial agonist. Tavapadon is effective in enabling movement and reducing disability and has the potential for Parkinson's disease .
    Tavapadon
  • HY-109012A
    Seltorexant hydrochloride
    3 Publications Verification

    JNJ-42847922 hydrochloride

    Orexin Receptor (OX Receptor) Neurological Disease Metabolic Disease
    Seltorexant hydrochloride (JNJ-42847922 hydrochloride) is an orally active, high-affinity, and selective OX2R antagonist (pKi values of 8.0 and 8.1 for human and rat OX2R). Seltorexant hydrochloride crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain .
    Seltorexant hydrochloride
  • HY-15446
    Basimglurant
    1 Publications Verification

    RG7090; RO4917523

    mGluR Neurological Disease
    Basimglurant (RG7090; RO4917523) is a selective, orally active, blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5), with a Ki of 1.4 nM (against [ 3H]-ABP688 (HY-110141)) and 35.6 nM (against [ 3H]-MPEP (HY-14609A)). Basimglurant inhibits mGlu5-mediated signaling pathways and receptor constitutive activity, regulates dopamine levels in the nucleus accumbens, exerts anxiolytic, antidepressant-like, analgesic and arousal-promoting effects, and alters δ-wave power during non-rapid eye movement sleep. Basimglurant can be used in research on depression, fragile X syndrome, anxiety disorders, etc .
    Basimglurant
  • HY-B0282A
    Acetylcholine bromide
    20+ Cited Publications

    ACh bromide

    Biochemical Assay Reagents Others Cancer
    Acetylcholine bromide is an organic choline salt compound commonly used in neurophysiology and pharmacology experiments. It plays an important role in the nervous system, acting as a neurotransmitter that transmits signals and regulates many important physiological functions. Due to its special biological activity, Acetylcholine bromide is widely used in the study of neurotransmitters, nerve damage and muscle movement.
    Acetylcholine bromide
  • HY-66012
    Proparacaine hydrochloride
    2 Publications Verification

    Proxymetacaine hydrochloride

    Sodium Channel Neurological Disease
    Proparacaine (Proxymetacaine) hydrochloride is a local anesthetic. Proparacaine hydrochloride blocks voltage-gated sodium channels on neuronal cell membranes, thereby inhibiting signal conduction and nociceptive signal transmission. Proparacaine hydrochloride blocks nociceptive signals in the eye and induces ocular muscle relaxation to reduce eye movement during surgery. Proparacaine hydrochloride is used in research related to cataracts .
    Proparacaine hydrochloride
  • HY-156659

    Phosphatase ERK Inflammation/Immunology
    NC1 is a selective non-competitive and allosteric lymphoid-specific tyrosine phosphatase (LYP) inhibitor, with a Ki value 4.3 μM. NC1 allosterically regulates LYP/PTPN22 activity by restricting WPD loop movement. NC1 inhibits LYP activity in lymphoid T cells and enhances T-cell receptor signaling. NC1 can be used for the research of autoimmune diseases .
    NC1
  • HY-145001

    LDLR CETP Metabolic Disease
    20-HC-Me-Pyrrolidine (compound AI-3d) is a potent Aster protein inhibitor with IC50s of 0.11 μM, 0.06 μM, and 0.71 μM for Aster-A, Aster-B, and Aster-C, respectively. 20-HC-Me-Pyrrolidine blocks the ability of Asters to bind and transfer cholesterol. 20-HC-Me-Pyrrolidine also inhibits the movement of low-density lipoprotein (LDL) cholesterol to the endoplasmic reticulum (ER) .
    20-HC-Me-Pyrrolidine
  • HY-B1904

    Dopamine Receptor Neurological Disease
    Fluphenazine decanoate is a CNS-penetrant dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .
    Fluphenazine decanoate
  • HY-D1569

    Fluorescent Dye Others
    CellTracker Orange CMRA Dye is a fluorescent dye. CellTracker Orange CMRA Dye can be used for cell imaging and monitoring the movement and location of cells .
    CellTracker Orange CMRA Dye (5/6-mixture)
  • HY-N1033

    Phytohormone Others
    12-Hydroxyjasmonic acidis is a COI1-JAZ-independent activator of leaf-closing movement in Samanea saman .
    12-Hydroxyjasmonic acid
  • HY-172741

    Drug Derivative Metabolic Disease
    Dioctanoyl PI(3,5)P2 sodium is a synthetic analog of PI(3,5)P2 (a natural phosphatidylinositol). Phosphatidylinositol phosphates (PIPs) are intracellular amphiphilic molecules implicated in numerous cellular responses including growth, division, movement, differentiation, neuro-exocytosis, and survival .
    Dioctanoyl PI(3,5)P2 sodium
  • HY-W013076

    tetra(decyl)ammonium bromide

    Biochemical Assay Reagents Others
    Tetrakis(decyl)ammonium bromide is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and is used in various industrial and biomedical applications. Tetrakis(decyl)ammonium bromide is commonly used as an emulsifier, solubilizer and antimicrobial agent in personal care products, cleansers and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, facilitating the movement of reactants between immiscible phases.
    Tetrakis(decyl)ammonium bromide
  • HY-W015050

    1-Aminoanthracene

    GABA Receptor Chloride Channel Fluorescent Dye Neurological Disease
    1-Anthramine (1-aminoanthracene) is a fluorescent general anesthetic. potentiates GABAergic transmission with Kd = 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin (HSAF). 1-Anthramine fluorescence is enhanced when bound to HSAF. 1-Anthramine potentiates chloride currents elicited by GABA. 1-Anthramine can reversibly inhibit the movement of Xenopus laevis, with an EC50 value of 16 μM .
    1-Anthramine
  • HY-W012167

    Environmental Pollutants Biochemical Assay Reagents Others
    N,N,N-Trimethyldecan-1-aminium chloride is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and thus useful in various industrial and biomedical applications. Decyltrimethylammonium chloride is commonly used as a surfactant, emulsifier and disinfectant in personal care products, detergents, textiles and pharmaceutical formulations. It is also used as a phase transfer catalyst in organic synthesis reactions, which involves facilitating the movement of reactants between immiscible phases.
    Decyltrimethylammonium chloride
  • HY-119902

    Insecticide Infection
    Bistrifluron is a benzoylphenylurea compound and orally active insecticide with activity against termites. At a concentration of 5,000 ppm, Bistrifluron acts as a bait toxicant against workers of the Formosan subterranean termite (Coptotermes formosanus), and also inhibits the grooming behavior of termites and impairs their motor ability prematurely .
    Bistrifluron
  • HY-139583

    S 117957; IMB 115

    Opioid Receptor Neurological Disease
    Sunobinop (S 117957; IMB 115) is an orally active and blood-brain barrier-permeable selective partial agonist of the human nociceptin/orphanin FQ receptor (NOP), which exhibits high affinity for human targets (Ki=3.3 nM; EC50=4.03 nM; Emax=47.8%) without activating μ and κ opioid receptors. Sunobinop significantly reduces wakefulness time and increases non-rapid eye movement sleep in rats by activating NOP receptors, and produces no significant side effects on learning, memory, reward, respiration or intestinal function at effective doses. Sunobinop displays competitive antagonist properties in specific signaling pathways, such as β-arrestin 2 recruitment. With these unique pharmacological properties, Sunobinop can be used to investigate insomnia, moderate-to-severe alcohol use disorder, and urinary incontinence caused by overactive bladder .
    Sunobinop
  • HY-112874

    BMS-687681

    CCR Neurological Disease Inflammation/Immunology Cancer
    BMS-681 is an orthosteric antagonist of CC chemokine receptor 2 (CCR2). BMS-681 restricts the movement of the extracellular end of TM6 by stabilizing TM7. TM7 and TM6 are the main components of the orthosteric binding site. BMS-681 can be used to study inflammatory neurodegenerative diseases and cancer .
    BMS-681
  • HY-W012412

    Biochemical Assay Reagents Others
    Tetrapropylammonium chloride is a compound belonging to the class of quaternary ammonium compounds. It is a salt with cationic properties and is used in various industrial and biomedical applications. Tetrapropylammonium chloride is commonly used as a phase transfer catalyst to facilitate the movement of reactants between immiscible phases in organic synthesis reactions. It is also used as a surfactant in the formulation of personal care products, detergents, textiles and pharmaceuticals. Additionally, it is used in the production of certain types of polymers and resins.
    Tetrapropylammonium chloride
  • HY-149483

    nAChR Neurological Disease
    CVN417 is an orally active α6 subunit-containing nAChR antagonist, modulating phasic dopaminergic neurotransmission in an impulse-dependent manner. CVN417 inhibits Ca(2+) effluents mediated by nAChR subunits with IC50s of 0.086 μM (α6), 2.56 μM (α3) and 0.657 μM (α4), respectively. CVN417 attenuates resting tremor in Rodent models, displays the potential to improve movement dysfunction, in conditions such as Parkinson's disease .
    CVN417
  • HY-141554

    DHTBZ

    Monoamine Transporter Neurological Disease
    Dihydrotetrabenazine (DHTBZ) is the active metabolite of Tetrabenazine (HY-B0590). Dihydrotetrabenazine is the inhibitor for human vesicular monoamine transporter 2 (VMAT2), that reduces monoamine content in presynaptic neurons, and can be used in movement disorder research .
    Dihydrotetrabenazine
  • HY-114901

    Adenosine Kinase Neurological Disease
    A-134974 is a novel, high-selectivity adenosine kinase (IC50 = 60 pM) inhibitor. A-134974 enhances endogenous adenosine signaling in the spinal cord, effectively alleviates neuropathic pain, and does not cause movement disorders. A-134974 can be used for the study of neuropathic pain .
    A-134974
  • HY-N3931

    Others Cardiovascular Disease
    Gardneramine is an orally active alkaloid that acts like papaverine. Gardneramine has peripheral vascular diastolic effect, direct inhibition on myocardium and central inhibition. Gardneramine showed antihypertensive, vasodilatation and atrial inhibition effects in rabbit, dog and guinea pig models, respectively. Gardneramine also inhibits the movement of smooth muscle organs such as the stomach and intestines .
    Gardneramine
  • HY-114899

    Environmental Pollutants Cholinesterase (ChE) Insecticide Infection Neurological Disease
    Azamethiphos is an acetylcholinesterase inhibitor and insecticide. Azamethiphos covalently binds to acetylcholinesterase via phosphorylation, inhibits its activity, causes acetylcholine to accumulate in cholinergic synapses, triggers uncontrolled excitation of cholinergic sites, induces paralysis and leads to death. Azamethiphos can be used as a bath insecticide in salmonid aquaculture to control sea lice infestations, and it exerts acute toxicity to European lobster larvae, including mortality and movement disorders .
    Azamethiphos
  • HY-P10360

    α-synuclein Neurological Disease
    Tat-βsyn-degron is an α-synuclein knockdown peptide that effectively degrades α-synuclein protein via the proteasome pathway. Tat-βsyn-degron effectively reduces α-synuclein protein levels in primary rat cortical neuron cultures. In a Parkinson's mouse toxicity model, Tat-βsyn-degron can alleviate parkinsonian toxin-induced neuronal damage and movement disorders .
    Tat-βsyn-degron
  • HY-B1277A

    mAChR Cholinesterase (ChE) Cardiovascular Disease Neurological Disease
    Trihexyphenidyl is a selective and orally active M1 muscarinic receptor antagonist with an IC50 of 3.7 nM for rat cerebral cortex M1 muscarinic receptors. Trihexyphenidyl modulates cholinergic activity, countering acetylcholine supersensitivity in neural pathways. Trihexyphenidyl improves movement disorder, inhibits McN-A-343 (HY-107648)-induced pressor responses, vagally-induced bradycardia and vasodilatation. Trihexyphenidyl can be used for the research of Parkinson's disease. .
    Trihexyphenidyl
  • HY-116919

    Lipoxygenase Cardiovascular Disease
    MLS000536924 is a potent and selective inhibitor of human epithelial 15-lipoxygenase-2 with competitive activity. MLS000536924 exhibits more than 50-fold selectivity in inhibiting h15-LOX-2 and can be effectively applied to study its role in atherosclerosis, cystic fibrosis, and ferroptosis. The binding mode of MLS000536924 shows stronger restriction of protein movement than other inhibitors, further verifying its higher biological activity .
    MLS000536924
  • HY-B1904A

    Dopamine Receptor Neurological Disease
    Fluphenazine decanoate dihydrochloride is a CNS-penetrant dopamine D2 receptor inhibitor, is a long-acting phenothiazine neuroleptic. Fluphenazine can be used for schizophrenia research .
    Fluphenazine decanoate dihydrochloride
  • HY-W017933

    Octahydro-1H-isoindole; Perhydroisoindole; Hexahydroisoindoline

    Neurokinin Receptor Neurological Disease
    Octahydroisoindole (Perhydroisoindole) is a substance P antagonist that can cross the blood-brain barrier and is useful for the study of movement disorders associated with central nervous system diseases .
    Octahydroisoindole
  • HY-W854295

    PtdIns-(1,2-dioctanoyl) sodium

    P-glycoprotein Cancer
    Phosphatidylinositol-1,2-dioctanoyl sodium significantly inhibits transmembrane P-gp transport in a reproducible, cell line-independent, and substrate-independent manner. Phosphatidylinositol-1,2-dioctanoyl sodium plays an important role in signal transduction and cell movement .
    Phosphatidylinositol-1,2-dioctanoyl sodium
  • HY-W010900

    Biochemical Assay Reagents Others
    Tetrahexylammonium bromide is a compound that belongs to the class of quaternary ammonium compounds. It is a salt with cationic properties and thus useful in various industrial and biomedical applications. Tetrahexylammonium bromide is commonly used as a phase transfer catalyst to facilitate the movement of reactants between immiscible phases in various organic synthesis reactions. It is also used as a surfactant and emulsifier in the formulation of detergents, personal care products and pharmaceuticals.
    Tetrahexylammonium bromide
  • HY-153091

    Adrenergic Receptor 5-HT Receptor Sigma Receptor Neurological Disease
    BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM .
    BMY 14802
  • HY-170475

    5-Methoxy-N-methyl-N-ethyltryptamine

    5-HT Receptor Neurological Disease
    5-MeO-MET (5-Methoxy-N-methyl-N-ethyltryptamine) is a 5-methoxytryptamines compound. 5-MeO-MET is the agonist of 5-HT1A and 5-HT2A. 5-MeO-MET can inhibit the movement of mice and has a sedative effect .
    5-MeO-MET
  • HY-176248

    Histamine Receptor Serotonin Transporter Neurological Disease Inflammation/Immunology
    Dimephosphon is an anti-inflammatory agent with antihistamine and antiserotonin activities. Dimephosphon helps maintain the conduction function of the spinal cord and reduces the excitability of spinal motor neurons in the area surrounding the lesion. Dimephosphon directly activates lymphatic vessel movement and improves lymphatic circulation. Dimephosphon can be used for the study of inflammatory edema, acute spinal cord injury and lymphatic circulation disorders .
    Dimephosphon
  • HY-N6609

    nAChR Others
    Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models .
    Magnocurarine
  • HY-136634

    mAChR Others
    BTM-1042 is a newly synthesized compound with antispasmodic effects. It can inhibit the twitch reaction of the guinea pig ileum under electrical stimulation and is not affected by naloxone. It has similar effects to atropine and can block muscarinic receptors, but has less effect on other types of receptors. BTM-1042 also has an inhibitory effect on the ileal reaction caused by nicotine and 5-hydroxytryptamine. BTM-1042 showed a dose-dependent inhibitory effect on the spontaneous movement of the rabbit stomach. In general, BTM-1042 is a agent with a strong antispasmodic effect.
    BTM-1042
  • HY-W362839

    5-HT Receptor Neurological Disease
    Binospirone is a 5-HT1A Receptor agonist. Binospirone has anxiolytic activity. Binospirone can be used in the study of movement disorders .
    Binospirone
  • HY-168365

    Drug Isomer Neurological Disease
    (±)-Pellotine hydrochloride (Compound 2) is an alkaloid, which is found in L. diffusa and L. fricii. (±)-Pellotine hydrochloride decreases locomotor activity and the amount of rapid eye movement (REM) sleep in mice .
    (±)-Pellotine hydrochloride
  • HY-105545C

    (+)-Benzetimide hydrochloride; (S)-(+)-Dexetimide hydrochloride; Dexbenzetimide hydrochloride

    mAChR Neurological Disease
    Dexetimide hydrochloride ((+)-Benzetimide hydrochloride) is an antimuscarinic drug with the activity of suppressing neuroleptic-induced Parkinson's syndrome. Dexetimide hydrochloride is used to improve the symptoms of movement disorders caused by the use of neuroleptics. Dexetimide hydrochloride, as the (-)-enantiomer of (-)-Benzetimide, shows the ability to selectively inhibit cholinergic receptors .
    Dexetimide hydrochloride
  • HY-113896

    Cholecystokinin Receptor Others
    U-67827E is a cholecystokinin (CCK) agonist that decreases food intake over a prolonged period of time in baboons. U-67827E may affect the latency to food by inhibiting the movement of food in the stomach and magnifying a gastric distention signal .
    U-67827E
  • HY-172348

    Bacterial Infection
    BRD-9327 is an inhibitor of EfpA. BRD-9327 binds in the outer vestibule without complete blockade of the substrate path to the outside, suggesting its possible inhibition of the movement necessary for alternate access of the transporter. BRD-9327 can be used for anti-tuberculosis study .
    BRD-9327

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