230 Results for "

neutralization

" in MedChemExpress (MCE) Product Catalog:
Products (230)

230 Results for "neutralization" in MCE Product Catalog:

735
735 Publications Verification
Cat. No.: HY-B0215
CAS No.: 616-91-1
Synonyms: N-Acetylcysteine; N-Acetyl-L-cysteine; NAC
Acetylcysteine (N-Acetylcysteine) is a mucolytic agent that can cross the blood-brain barrier, which reduces the thickness of the mucus. Acetylcysteine is a ROS inhibitor. Acetylcysteine is a cysteine precursor, prevents hemin-induced ferroptosis by neutralizing toxic lipids generated by arachidonate-dependent activity of 5-lipoxygenases. Acetylcysteine induces cell apoptosis. Acetylcysteine also has anti-influenza virus activities. In addition, Acetylcysteine ​​is the most stable form of cysteine ​​during drug delivery and can be used in disulfidptosis studies .
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45
45 Cited Publications
Cat. No.: HY-P9917
CAS No.: 375823-41-9
Synonyms: Anti-Human IL6R, Humanized Antibody; RG-1569; rhPM-1
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .
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28
28 Cited Publications
Cat. No.: HY-100561
CAS No.: 2226-96-2
Purity:  99.73%
Synonyms: 4-Hydroxy-TEMPO
Research Areas:  

Cancer

Tempol is a general superoxide dismutase (SOD)-mimetic agent that efficiently neutralizes reactive oxygen species (ROS).
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26
26 Cited Publications
Cat. No.: HY-A0248
CAS No.: 1405-20-5
Polymyxin B Sulfate is an antibiotic. Polymyxin B Sulfate inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B Sulfate neutralizes the effect of endotoxin. Polymyxin B Sulfate induces bacterial death by increasing its permeability. Polymyxin B Sulfate is used in endotoxemia research .
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26
26 Cited Publications
Cat. No.: HY-149179
CAS No.: 1404-26-8
Purity:  ≥91.0%
Target:  

Antibiotic Bacterial

Research Areas:  

Infection

Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research .
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13
13 Cited Publications
Cat. No.: HY-B1610I
CAS No.: 6132-04-3
Synonyms: Trisodium citrate dihydrate, for molecular biology
Sodium citrate dihydrate, for molecular biology is an antacid used in studies to neutralize gastric acid. Sodium citrate dehydrate is often used to prepare biological buffers and can be used in molecular biology research .
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12
12 Cited Publications
Cat. No.: HY-P9927
CAS No.: 1229022-83-6
Synonyms: AIN457

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology Cancer

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis .
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6
6 Cited Publications
Cat. No.: HY-P99340
CAS No.: 2423014-07-5
Synonyms: VIR 7831; GSK-4182136

Target:  

SARS-CoV

Research Areas:  

Infection Cancer

Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
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5
5 Cited Publications
Cat. No.: HY-P99137

Target:  

IFNAR

Research Areas:  

Inflammation/Immunology

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3) .
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4
4 Cited Publications
Cat. No.: HY-P99129

Research Areas:  

Inflammation/Immunology

Anti-Mouse CD8a Antibody (53-6.7) is an anti-mouse CD8a IgG2a antibody inhibitor derived from host Rat. Anti-Mouse CD8a Antibody (53-6.7) binds to CD8αβ stabilizes a conformation with a higher affinity for interaction with MHC class I. Anti-Mouse CD8a Antibody (53-6.7) induces the phosphorylation and activation of TCR proximal signaling pathway components Lck and ZAP70 in polyclonal memory T cells. Anti-Mouse CD8a Antibody (53-6.7) depletes CD8+ T cells and neutralizes cytokine in mice .
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3
3 Cited Publications
Cat. No.: HY-107911
CAS No.: 9009-65-8
Purity:  99.99%
Target:  

Thrombin

Research Areas:  

Metabolic Disease

Protamine sulfate, polycationic peptide and a antiheparin agent, could neutralize the anticoagulant action of heparin and enhances lipid-mediated gene transfer .
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3
3 Cited Publications
Cat. No.: HY-P99305
CAS No.: 272780-74-2
Synonyms: CAT-192; Anti-TGFB1 Recombinant Antibody

Target:  

TGF-β Receptor

Research Areas:  

Inflammation/Immunology

Metelimumab (CAT-192) is a human IgG4 monoclonal antibody that can selectively neutralize TGFβ1 .
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3
3 Cited Publications
Cat. No.: HY-108628
CAS No.: 251356-45-3
Purity:  99.36
Target:  

PDGFR

Research Areas:  

Cancer

SU16f is a potent and selective PDGFRβ inhibitor with IC50s of 10 nM, 140 nM, 2.29 μM for PDGFRβ, VEGF-R2, FGF-R1, respectively . Neutralization of PDGFRβ receptor by SU16f blocks the promoting role of GC-MSCs (gastric cancer-derived mesenchymal stem cells) conditioned medium in gastric cancer cell proliferation and migration .
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3
3 Cited Publications
Cat. No.: HY-P9924
CAS No.: 1143503-69-8
Synonyms: LY2439821

Target:  

Interleukin Related

Research Areas:  

Inflammation/Immunology

Ixekizumab (LY2439821) is a humanized IgG4 monoclonal antibody that selectively binds and neutralizes interleukin IL-17A (KD<3 pM). Ixekizumab directly blocks IL-17A binding to IL-17RA (IL-17A receptor) but does not bind to other IL-17 family members. Ixekizumab is used for the research of moderate-to-severe plaque psoriasis .
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2
2 Cited Publications
Cat. No.: HY-P99275
CAS No.: 1262787-83-6
Synonyms: AMG-888; U3-1287

Target:  

EGFR Akt ERK PARP Survivin

Research Areas:  

Cancer

Patritumab (Human Anti-ERBB3 Recombinant Antibody) is a neutralizing monoclonal antibody to ERBB3. Patritumab shows a synergy with Cetuximab (HY-P9905), potently inhibits the phosphorylation of EGFR, HER2, HER3, ERK, and AKT. Patritumab also induces cell apoptosis and suppresses the growth of pancreatic, non-small cell lung cancer, and colorectal cancer xenograft tumors .
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2
2 Cited Publications
Cat. No.: HY-P99756
CAS No.: 1989556-22-0
Synonyms: MEDI8897

Target:  

RSV

Research Areas:  

Infection

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections .
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2
2 Cited Publications
Cat. No.: HY-P9953
CAS No.: 428863-50-7
Synonyms: Certolizumab; CDP870

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology Cancer

Certolizumab pegol (Certolizumab) is a recombinant, polyethylene glycosylated, antigen-binding fragment of a humanized monoclonal antibody that selectively targets and neutralizes tumour necrosis factor-α (TNF-α). Certolizumab pegol can be used for rheumatoid arthritis and Crohn disease research .
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2
2 Cited Publications
Cat. No.: HY-P99053
CAS No.: 1044515-88-9
Synonyms: CAT354
Tralokinumab (CAT354) is a humanized IgG4 monoclonal antibody that specifically binds to and neutralizes IL-13. Tralokinumab can be used in the research of diseases such as asthma, atopic dermatitis, and pulmonary fibrosis .
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2
2 Cited Publications
Cat. No.: HY-P99100
CAS No.: 2556646-63-8
Synonyms: CTL-002

Research Areas:  

Cancer

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
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2
2 Cited Publications
Cat. No.: HY-P99020
CAS No.: 948564-73-6
Synonyms: GC1008

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease .
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