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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
50 Results for "
preadipocyte
" in MedChemExpress (MCE) Product Catalog:
Products (50)
50 Results for "preadipocyte" in MCE Product Catalog:
25
25 Publications Verification
Synonyms: CDDO; RTA 401
Target:
Keap1-Nrf2 NF-κB SARS-CoV Apoptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase Necroptosis
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
Bardoxolone (CDDO; RTA 401) is a Nrf2 activator. Bardoxolone shows anti-SARS-CoV-2 3CLpro with IC50 of 27.99 μM. Bardoxolone activates the Nrf2 pathway and inhibits the NF-κB pathway. Bardoxolone can induce cells differentiation, apoptosis and shows antiproliferative activity against cancer cells. Bardoxolone can increase ROS and decrease intracellular GSH levels. Bardoxolone inhibits Z-VAD-FMK (HY-16658B)-induced necroptosis. Bardoxolone can be used for the research of cancer, inflammation and infection, such as SARS-CoV infection and glioblastoma .
22
22
4
4 Cited Publications
Synonyms: Cichoric acid; Dicaffeoyltartaric acid
4
4 Cited Publications
Cat. No.: HY-N2593
CAS No.: 32507-66-7
4
4 Cited Publications
Cat. No.: HY-N0226A
CAS No.: 889665-86-5
3
2
2 Cited Publications
Synonyms: Chromium acetate; Chromic acetate; Chromium triacetate
Target:
Research Areas:
Chromium(III) acetate (Chromic acetate) is an AMPK inhibitor that promotes lipogenesis by inhibiting AMPK phosphorylation. Chromium(III) acetate has low toxicity in mammals, with an LD50 of 2365 mg/kg in rats .
2
2
2 Cited Publications
Cat. No.: HY-N1970
CAS No.: 31721-94-5
Category:
other families Flavonoids Phenols Polyphenols Plants Isoflavones
Target:
1
Category:
Human Gut Microbiota Metabolites Microorganisms Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endogenous metabolite
Target:
1
Research Areas:
Tafluprost acid (AFP-172), an active metabolic form of Tafluprost, is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM, respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma .
1
1 Cited Publications
Target:
Research Areas:
PPARγ-IN-2 (Compound 5a) is a PPARγ inhibitor. PPARγ-IN-2 inhibits TG accumulation in 3T3-L1 preadipocytes (EC50: 0.106 μM). PPARγ-IN-2 inhibits high-cholesterol diet (HFC)-induced obesity and related metabolic syndrome, and reduces lipid accumulation in adipose tissue .
1
1 Cited Publications
Cat. No.: HY-N3027
CAS No.: 117230-33-8
Category:
Triterpenes Leguminosae Glycine max (L.) merr Terpenoids Metabolic Disease Plants Disease Research Fields
Target:
1
1 Cited Publications
Cat. No.: HY-N4253
CAS No.: 173792-61-5
Cat. No.: HY-W014901
CAS No.: 620-92-8
Synonyms: BPF; 4,4'-Dihydroxydiphenylmethane
Target:
Category:
Target:
Research Areas:
JTE-907 is a selective and orally active cannabinoid CB2 receptor inverse agonist and exerts anti-inflammatory effects. JTE-907 upregulates IL-6, MCP-1, IL-1β, VEGF, ANGPTL4, and TRPV1 in mature adipocytes. JTE-907 downregulates CB1, MCP-1, and IL-1β in preadipocytes. JTE-907 inhibits ear swelling in mice. JTE-907 reverses the protective effects of CB2 agonists and Anandamide (HY-10863) against cytokine-evoked colonic mucosal damage. JTE-907 can be used for the research of allergic dermatitis, obesity, and colitis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
