Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
160 Results for "
serine protease inhibitor
" in MedChemExpress (MCE) Product Catalog:
Products (160)
160 Results for "serine protease inhibitor" in MCE Product Catalog:
163
163 Publications Verification
Synonyms: Phenylmethylsulfonyl fluoride; Benzylsulfonyl fluoride
Target:
Research Areas:
PMSF (Phenylmethylsulfonyl fluoride) is a nonspecific and irreversible serine proteases inhibitor. PMSF inhibits some thiol proteases, non-protease enzymes, and acetylcholinesterase. PMSF can be used to prepare protein extracts from tissue and cell lysates .
49
49 Cited Publications
Synonyms: Camostat mesilate; FOY305; FOY-S980
Target:
Research Areas:
Camostat mesylate (Camostat mesilate) is an orally active, synthetic serine protease inhibitor for chronic pancreatitis. Camostat mesylate, an inhibitor of TMPRSS2, shows antiviral activity against SARS-CoV-2. Camostat mesylate also inhibits the activity of prostasin, trypsin, and matriptase .
20
20 Cited Publications
Target:
Research Areas:
AEBSF hydrochloride is an irreversible inhibitor of serine proteases, such as chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
19
Nafamostat mesylate (FUT-175), an anticoagulant, is a synthetic serine protease inhibitor. Nafamostat mesylate has anticancer and antivirus effect. Nafamostat mesylate induce apoptosis by up-regulating the expression of tumor necrosis factor receptor-1 (TNFR1). Nafamostat mesylate can be used in the development of the pathological thickening of the arterial wall .
5
Target:
Research Areas:
Ulinastatin (Uristatin) is a trypsin and serine protease inhibitor. Ulinastatin is the main protein binding inhibitor of various trypsin, chymotrypsin, and various pancreatic proteases. Ulinastatin shows neuroprotective, anti-inflammatory, anti-apoptotic, anti-oxidant effects .
5
5 Cited Publications
Synonyms: SCH 900518; Arlansa
Target:
Research Areas:
Narlaprevir (SCH 900518) is a selective and orally bioavailable NS3 protease inhibitor with a Ki value of 6 nM and an EC90 value of 40 nM . Narlaprevir also inhibits the HCV nonstructural protein 3 serine protease . Narlaprevir is also a SARS-CoV 3CL pro inhibitor with an IC50 of 2.3 μM .
4
4 Cited Publications
Cat. No.: HY-P1918
CAS No.: 146340-20-7
Target:
Research Areas:
3
3 Cited Publications
Cat. No.: HY-P70975
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA5; Acrosomal serine protease inhibitor; Prev. PLANH3; PAI-3; Prev. PCI; Plasminogen Activator inhibitor III; PROCI; Plasminogen Activator inhibitor-3; PAI3; Plasminogen Activator inhibitor 3; Protein C inhibitor; Serpin A5; serine (Or Cysteine) Pro
Species:
Human
Source:
HEK293
2
2 Cited Publications
Target:
Research Areas:
Lalistat 1 is a potent, selective, and competitive inhibitor of lysosomal acid lipase (LAL) and against purified human LAL (phLAL) with an IC50 of 68 nM. Lalistat 1 is a inhibitor of immunoglobulin A1 protease (IgA1P) proteases for H. influenzae, has less effects on other serine hydrolases (trypsin or β-lactamase, etc.). Lalistat 1 can be used for the research of niemann-pick type C (NPC) disease .
2
Target:
Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer .
1
1
1 Cited Publications
Cat. No.: HY-P73526
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPING1; serine (Or Cysteine) Proteinase inhibitor, Clade G (C1 inhibitor), Member 1, (Angioedema, Hereditary); Prev. C1NH; serine/Cysteine Proteinase inhibitor Clade G Member 1 Splice Variant 2; Plasma protease C1 inhibitor; serine/Cysteine Proteinase I
Species:
Human
Source:
HEK293
1
1 Cited Publications
Target:
Research Areas:
Ucf-101 is a selective and competitive inhibitor of pro-apoptotic protease Omi/HtrA2, with an IC50 of 9.5 μM for His-Omi. Ucf-101 exhibits very little activity against various other serine proteases (IC50>200 μM). Ucf-101 has a natural red fluorescence at 543 nm that is used to monitor its ability to enter mammalian cells. Ucf-101 has a significant cardioprotective effect against MI/R injury and also has certain neuroprotective effect .
1
1 Cited Publications
Target:
Research Areas:
NA-184 is a selective and brain-penetrant calpain-2 inhibitor with an IC50 of 134 nM for mouse calpain-2. NA-184 has weak inhibitory activity on calpain-1 (IC50 of 2826 nM). NA-184 does not exhibit significant inhibition on a variety of other cysteine-, serine- or metallo-proteases. NA-184 shows significant neuroprotection and can be used for the study of traumatic brain injury (TBI) .
1
1 Cited Publications
Synonyms: L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK
Target:
Research Areas:
Infection Neurological Disease Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is an effective serine protease inhibitor and also a blocker of the PDK1/Akt pathway. TPCK can modify the E7 protein in actively keratinocyte cells. TPCK can induce cellular apoptosis, suppress tumor growth, reduce hypoxic-ischemic brain injury in rat pups, and affect vascular permeability in inflamed rats .
1
1 Cited Publications
Cat. No.: HY-P71143
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: SERPINA4; Testicular Secretory Protein Li 22; Prev. PI4; Peptidase inhibitor 4; KST; Kallikrein inhibitor; Kallistatin; Serpin A4; KLST; PI-4; KAL; Serpin Peptidase inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4, Isoform CRA_a; serine (Or Cysteine) Proteinase inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; protease inhibitor 4 (Kallistatin); Serpin Peptidase inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 4; Serpin Family A Member 4; Sserpin Family A Member 4
Species:
Human
Source:
HEK293
Cat. No.: HY-W010128
CAS No.: 938-55-6
Synonyms: 6-Dimethylaminopurine; 6-DMAP
Category:
Target:
Target:
Research Areas:
Recombinant aprotinin is a serine protease inhibitor. Recombinant aprotinin can inhibit trypsin and related proteolytic enzymes .
Cat. No.: HY-33900
CAS No.: 22929-52-8
Synonyms: 3-Oxotetrahydrofuran
Target:
Research Areas:
Dihydrofuran-3(2H)-one (3-Oxotetrahydrofuran) is a cyclic ketone that can be used to synthesize cyclic ketone inhibitors that inhibit the serine protease plasmin .
Category:
Target:
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
