307 Results for "

spike

" in MedChemExpress (MCE) Product Catalog:
Products (307)

307 Results for "spike" in MCE Product Catalog:

42
42 Publications Verification
Cat. No.: HY-14393
CAS No.: 518-82-1
Purity:  99.25%
Synonyms: Frangula emodin
Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects . Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
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8
8 Cited Publications
Cat. No.: HY-112829
CAS No.: 1399177-37-7
Purity:  99.58%
Synonyms: TVB-2640; FASN-IN-2; ASC-40
Research Areas:  

Metabolic Disease Cancer

Denifanstat (TVB-2640) is an orally active and potent Fatty Acid Synthase (FASN) inhibitor with an IC50 of 0.052 μM and an EC50 of 0.072 μM. Denifanstat has the potential for fatty liver disease and cancer research .
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2
2 Cited Publications
Cat. No.: HY-15275
CAS No.: 582315-72-8
Purity:  99.59%
BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research .
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2
2 Cited Publications
Cat. No.: HY-P7436
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: 2019-nCov RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD
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1
1 Cited Publications
Cat. No.: HY-153083
Target:  

mRNA SARS-CoV

Research Areas:  

Infection

COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) is an mRNA encoding the SARS-CoV-2 spike protein with enhanced performance via chemical modification. COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) replaces natural uridine (UTP) with N1-Me-Pseudo UTP, which effectively reduces immunogenicity and improves stability and translation efficiency. The 3' UTR of COVID-19 Spike Protein mRNA (N1-Me-Pseudo UTP) optimizes AU-rich elements through HuR anchor sites, exhibiting higher translation efficiency. COVID-19 Spike Protein mRNA is widely used in COVID-19-related scientific research and vaccine development .
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1
1 Cited Publications
Cat. No.: HY-P99435
CAS No.: 2509447-07-6
Synonyms: BRII-196

Target:  

SARS-CoV

Research Areas:  

Infection

Amubarvimab (BRII-196) is a human IgG1 mAb that bind to non-competing epitopes on the receptor binding domain (RBD) of spike protein, with a KD of 5.88 nM. Amubarvimab can effectively neutralize SARS-CoV-2 variants .
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1
1 Cited Publications
Cat. No.: HY-P9801
Synonyms: SARS-CoV-2 (2019-nCoV) spike RBD Antibody

Target:  

SARS-CoV

Research Areas:  

Infection

Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
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1
1 Cited Publications
Cat. No.: HY-P73397
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: 2019-nCov RBD Protein; 2019-nCoV spike RBD Protein; S protein RBD; 2019-nCoV S protein RBD
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1
1 Cited Publications
Cat. No.: HY-18663
CAS No.: 199655-36-2
Target:  

iGluR

Research Areas:  

Neurological Disease

CP-465022 is a potent, and selective noncompetitive AMPA receptor antagonist with anticonvulsant activity. CP-465022 is against Kainate-induced response with an IC50 of 25 nM in rat cortical neurons. CP-465022 provides a new tool to investigate the role of AMPA receptors in physiological and pathophysiological processes .
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1
1 Cited Publications
Cat. No.: HY-B1243
CAS No.: 550-83-4
Target:  

Sodium Channel

Research Areas:  

Neurological Disease

Propoxycaine hydrochloride is a voltage-gated sodium channel inhibitor. Propoxycaine hydrochloride delays monophasic A spike action potential recovery. Propoxycaine hydrochloride increases bulk lateral, rotational, and annular lipid fluidity in neuronal membrane lipid bilayers, with greater inner monolayer fluidization, and induces membrane protein clustering. Propoxycaine hydrochloride can be used for the research of pain .
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1
1 Cited Publications
Cat. No.: HY-W013151
CAS No.: 114932-60-4
Research Areas:  

Others

1-Pyrenebutyric acid N-hydroxysuccinimide ester (PANHS) is a linker and interface coupling agent that can be used to prepare electrochemical biosensors. 1-Pyrenebutyric acid N-hydroxysuccinimide ester immobilizes SARS-CoV-2 spike antibodies on graphene sheets. 1-Pyrenebutyric acid N-hydroxysuccinimide ester is often used as an activation reagent for carboxylic acids in organic chemistry or biochemistry .
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1
1 Cited Publications
Cat. No.: HY-P99342
CAS No.: 2415933-40-1
Synonyms: REGN10987

Target:  

SARS-CoV

Research Areas:  

Infection

Imdevimab (REGN10987) is a human monoclonal antibody that targets SARS-CoV-2 virus. Imdevimab can be used in combination with Casirivimab (HY-P99341) to reduce viral load and transiently increases anti-receptor-binding domain IgG titers. Imdevimab maintains most of its neutralization activity against viruses with B.1.1.7, B.1.351 and mink cluster 5 spike proteins .
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1
1 Cited Publications
Cat. No.: HY-P78283
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: S protein RBD; S glycoprotein RBD; spike protein RBD
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1 Cited Publications
Cat. No.: HY-N2787
CAS No.: 53846-50-7
8-Prenylnaringenin is an orally active prenyl flavonoid. 8-Prenylnaringenin can be isolated from the hop spike Humulus lupulus. 8-Prenylnaringenin activates the PI3K/Akt pathway and the AMPK pathway, upregulates OXPHOS complexes (II, III, and V) and Sirt1, and reduces ROS production and SOD activity. 8-Prenylnaringenin improves muscle atrophy and obesity and inhibits angiogenesis. 8-Prenylnaringenin exhibits anticancer activity against glioblastoma and colon cancer. 8-Prenylnaringenin also has LH/FSH regulatory activity. 8-prenylnaringenin may be used in bone health research .
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Cat. No.: HY-P11146
CAS No.: 175483-64-4
Synonyms: Sakacin P inducer peptide
Target:  

Bacterial

Research Areas:  

Infection

SppIP (Sakacin P inducer peptide) is a peptide consisting of 19 amino acids . SppIP is an essential inducer for sakacin P production . SppIP can induce the expression of PRRSV GP5 and SARS-CoV-2 spike protein in recombinant Lactobacillus plantarum. SppIP can activate the transcription of the sakacin P promoter to drive the expression of downstream heterologous capsid proteins, increasing the proportion of PCV2d capsid proteins displayed on the cell surface of Lactobacillus plantarum. SppIP can be used in studies related to sakacin P induction .
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Cat. No.: HY-153235
COVID-19 Spike Protein mRNA-LNP is a lipid nanoparticle (LNP) containing mRNA encoding COVID-19 Spike Protein. COVID-19 Spike Protein undertakes the functions of virus binding with host cell receptors, thereby mediating the entry of COVID-19 virus into cells. COVID-19 Spike Protein is an important site of action for host neutralizing antibodies and a key target for vaccine design. COVID-19 Spike Protein mRNA-LNP can be used for RNA delivery, vaccine formulation and design targeting SARS-CoV-2 .
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Cat. No.: HY-P99344
CAS No.: 2423943-37-5
Synonyms: Anti-Human SARS-CoV-2; LY-3819253; LY-CoV555

Target:  

SARS-CoV

Research Areas:  

Infection

Bamlanivimab (Anti-Human SARS-CoV-2; LY-CoV555) is an antiviral agent targeting the SARS-CoV-2 spike protein receptor-binding domain (RBD) with a mean Kd of 5.3 nM. Bamlanivimab binds epitopes overlapping the ACE2 binding site on both active and resting RBD conformations, blocks ACE2 attachment, mediates antibody-dependent cell-mediated cytotoxicity, and reduces viral replication and respiratory tract viral load. Bamlanivimab can be used for the research of COVID-19 .
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Cat. No.: HY-P99346
CAS No.: 2444308-95-4
Synonyms: CT-P59

Research Areas:  

Infection

Regdanvimab (CT-P59) is a human monoclonal antibody that targets the receptor-binding domain of SARS-CoV-2 spike protein, blocking interaction with ACE2 for viral entry. Regdanvimab can be used for the research of COVID-19 .
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Cat. No.: HY-158694A
Purity:  99.86%
Research Areas:  

Inflammation/Immunology

TLR7 agonist 20 hydrochloride is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 0.22 μM. TLR7 agonist 20 hydrochloride, as an immunostimulant and vaccine adjuvant, enhances the production of anti-spike protein antibodies, increases IgG2b and IgG2c levels, and thereby drives Th1-type immune responses in mice. TLR7 agonist 20 hydrochloride can be used in studies related to non-inflammatory potent vaccine adjuvants .
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Cat. No.: HY-P3089A
Target:  

Potassium Channel

Research Areas:  

Others

Dendrotoxin K TFA is a Kv1.1 channel blocker. Dendrotoxin K TFA determines glutamate release in CA3 neurons in a time-dependent manner through the control of the presynaptic spike waveform .
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