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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
synaptosomal
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "synaptosomal" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P73634
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SNAP25; SEC9; Prev. SNAP; synaptosomal-Associated Protein, 25kDa; SNAP-25; SUP; synaptosomal-Associated Protein 25; synaptosomal-Associated 25 KDa Protein; DJ1068F16.2; Synaptosome Associated Protein 25kDa; BA416N4.2; Super Protein; RIC-4; DEE117; RIC4; C
Species:
Human
Source:
E. coli
Cat. No.: HY-N6745
CAS No.: 25425-12-1
Category:
Cardiovascular Disease Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-124030
CAS No.: 70030-11-4
Target:
Research Areas:
3-Hydroxyphenazepam is an active metabolite of Cinazepam. Cinazepam is a GABAA receptor agonist. 3-Hydroxyphenazepam can inhibit synaptosomal transporter-mediated [ 3H]GABA uptake .
Cat. No.: HY-106407
CAS No.: 135928-30-2
Synonyms: Org 4428; ADL 6906
Target:
Research Areas:
Beloxepin (Org 4428) is an orally active synaptosomal noradrenalin reuptake inhibitor and a 5-HT2 receptor antagonist. Beloxepin shows about 100-fold less affine for other monoamine carriers. Beloxepin has antidepressant and pain-relieving effects .
Cat. No.: HY-P3071
CAS No.: 172450-46-3
Synonyms: Stichodactyla helianthus neurotoxin
Target:
Research Areas:
Cat. No.: HY-W127407
CAS No.: 201738-25-2
Target:
Research Areas:
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.
Cat. No.: HY-131527R
CAS No.: 93413-90-2
Synonyms: N-Desmethyl Venlafaxine hydrochloride (Standard); Wy 45494 (Standard)
Research Areas:
Wy-45494 (hydrochloride) (Standard) is the analytical standard of Wy-45494 (hydrochloride). This product is intended for research and analytical applications. Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Cat. No.: HY-P11029
Target:
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Cat. No.: HY-117251
CAS No.: 1142050-84-7
Target:
Research Areas:
LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC50=0.11 μM; Ki=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC50=0.23 μM). LP-403812 can be used to study the function of PROT in the brain .
Cat. No.: HY-P3071A
Synonyms: Stichodactyla helianthus neurotoxin TFA
Target:
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Cat. No.: HY-110016
CAS No.: 150314-35-5
Synonyms: DEA
Cat. No.: HY-P11030
Target:
Research Areas:
Cat. No.: HY-114040
CAS No.: 159094-94-7
Synonyms: NNC-711 free acid
Target:
Research Areas:
NO-711 (NNC-711) free acid is a novel potent and selective inhibitor of γ-aminobutyric acid uptake. NO-711 inhibits synaptosomal (IC50 = 47 nM), neuronal (IC50 = 1238 nM) and glial (IC50 = 636 nM) GABA uptake in vitro .
Target:
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CGS 8216 is a non-benzodiazepine brain benzodiazepine receptor ligand that binds to rat forebrain membranes with high affinity and specificity. CGS 8216 also inhibits 3H-flunitrazepam (3H-FLU) binding to rat synaptosomal membranes and blocks 3H-FLU labeling of brain benzodiazepine receptors in vivo with potency equivalent to Diazepam .
Cat. No.: HY-W015912S
Synonyms: 2-Furyl methyl ketone-d3
Cat. No.: HY-131527
CAS No.: 93413-90-2
Synonyms: N-Desmethyl Venlafaxine hydrochloride; Wy 45494
Target:
Research Areas:
Wy-45494 hydrochloride (N-Desmethyl Venlafaxine hydrochloride; Wy 45494) is a minor active metabolite of the selective norepinephrine and serotonin reuptake inhibitor (SNRI) venlafaxine. It is formed from venlafaxine via the cytochrome P450 (CYP) isomer CYP3A4.2. Wy-45494 hydrochloride inhibits norepinephrine and serotonin reuptake in rat synaptosomal preparations (IC50s of 4.7 and 1.6 μM, respectively). In vivo, Wy-45494 hydrochloride reversed reserpine-induced hypothermia in mice at a minimum effective dose (MED) of 10 mg/kg.
Cat. No.: HY-105521A
CAS No.: 94096-42-1
Synonyms: (S)-Nafenodone; LU-43706
Target:
Research Areas:
Dexnafenodone hydrochloride ((S)-Nafenodone; LU-43706) is a novel antidepressant candidate molecule that selectively inhibits the norepinephrine synaptosomal uptake transporter. Dexnafenodone hydrochloride inhibits the fast inward Na + current and slow inward Ca 2+ current in cardiomyocytes. Dexnafenodone hydrochloride inhibits voltage-gated and receptor-activated Ca 2+ influx in vascular smooth muscle, depletes norepinephrine-sensitive intracellular Ca 2+ stores, suppresses agonist-stimulated Ca 2+ influx, relaxes precontracted vascular smooth muscle, inhibits spontaneous myogenic activity, and modulates cardiac electrophysiology, exerting negative chronotropic and negative inotropic effects. Dexnafenodone hydrochloride can be used in the research of depression .
Cat. No.: HY-113410R
CAS No.: 626-51-7
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
