1. Cell Cycle/DNA Damage
    Anti-infection
  2. DNA Alkylator/Crosslinker
    Antibiotic
  3. Sibiromycin

Sibiromycin 

Cat. No.: HY-N9460
Handling Instructions

Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine.

For research use only. We do not sell to patients.

Sibiromycin Chemical Structure

Sibiromycin Chemical Structure

CAS No. : 12684-33-2

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Description

Sibiromycin is a naturally produced glycosylated pyrrolobenzodiazepines (PBDs). Sibiromycin is also a potent antitumor antibiotic that binds covalently to DNA in the minor groove at the NH2 of guanine[1][2].

In Vitro

Pyrrolobenzodiazepines (PBDs) are sequence selective DNA alkylating agents with remarkable antineoplastic activity[1].
Alkylation of DNA by anthramycin, sibiromycin and tomaymycin is sequence specific with the following trend for binding preference 5′-Pu-G-Pu>5′-Py-G-Pu>5′-Pu-G-Py>5′-Py-G-Py[1].
Sibiromycin shows cytotoxicity against L1210 (leukemia), ADJ/PC6 (plasmacytoma) and CH1 (ovarian) cells with IC50s of ranging 0.000017 ~0.0029 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

475.53

Formula

C₂₄H₃₃N₃O₇

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Sibiromycin
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HY-N9460
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