Sildenafil-d3
Based on 1 Customer Validation
Sildenafil-d3 is deuterium labeled Sildenafil-d3. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
For research use only. We do not sell to patients.
- Purity: 99.87%
- CAS No.: 1126745-90-1
- Formula: C22H27D3N6O4S
- Molecular Weight:477.59
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PDE5 |
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1126745-90-1
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Unlabeled Cas 139755-83-2
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Appearance Solid
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Molecular Weight 477.59
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Formula C22H27D3N6O4S
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Color White to off-white
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SMILES
CCOC1=C(C=C(S(N2CCN(CC2)C([2H])([2H])[2H])(=O)=O)C=C1)C(NC3=C4N(N=C3CCC)C)=NC4=O
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Synonyms
UK-92480-d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 25 mg/mL (52.35 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10(11):2790-7 [Content Brief]
[2]. [2].Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl). 2011 Sep;124(17):2733-40. [Content Brief]
[3]. [3]. Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13(1):95. [Content Brief]
[4]. Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33(2):204-11. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0938 mL | 10.4692 mL | 20.9385 mL | 52.3462 mL |
| 5 mM | 0.4188 mL | 2.0938 mL | 4.1877 mL | 10.4692 mL | |
| 10 mM | 0.2094 mL | 1.0469 mL | 2.0938 mL | 5.2346 mL | |
| 15 mM | 0.1396 mL | 0.6979 mL | 1.3959 mL | 3.4897 mL | |
| 20 mM | 0.1047 mL | 0.5235 mL | 1.0469 mL | 2.6173 mL | |
| 25 mM | 0.0838 mL | 0.4188 mL | 0.8375 mL | 2.0938 mL | |
| 30 mM | 0.0698 mL | 0.3490 mL | 0.6979 mL | 1.7449 mL | |
| 40 mM | 0.0523 mL | 0.2617 mL | 0.5235 mL | 1.3087 mL | |
| 50 mM | 0.0419 mL | 0.2094 mL | 0.4188 mL | 1.0469 mL |
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