1. Autophagy
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Autophagy
    Reactive Oxygen Species
  3. Silibinin

Silibinin (Synonyms: Silibinin A; Silymarin I)

Cat. No.: HY-13748 Purity: 99.87%
Handling Instructions

Silibinin (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

For research use only. We do not sell to patients.

Silibinin Chemical Structure

Silibinin Chemical Structure

CAS No. : 22888-70-6

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
500 mg USD 96 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Silibinin:

Top Publications Citing Use of Products

    Silibinin purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Aug 14;11(8):630.

    Representative images acquired by confocal microscopy combined with immunochemical staining shows that Silibinin (200 μM) induced accumulation of AIF in the nucleus of U87 cell.

    Silibinin purchased from MCE. Usage Cited in: Cell Death Dis. 2020 Aug 14;11(8):630.

    Silibinin (200 μM)-induced accumulation of AIF in nuclear fraction is decreased in the cells transfected with AIF SiRNA.
    • Biological Activity

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    Description

    Silibinin (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

    In Vitro

    Silibinin (Silybin) significantly induced the expression of the non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) in both p53 wild-type and p53-null cancer cell lines[1].
    Silibinin (Silybin) induced cell death in human breast cancer cell lines MCF7 and MDA-MB-231[2].
    Silibinin (Silybin) treatment resulted in a dose- and time-dependent inhibition of HCC cell viability[3].
    Silibinin (Silybin) treatment decreased the expression of the Notch1 intracellular domain (NICD), RBP-Jκ, and Hes1 proteins, upregulated the apoptosis pathway-related protein Bax, and downregulated Bcl2, survivin, and cyclin D1[3].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    In Vivo

    Topical application of silibinin at the dose of 9 mg/mouse effectively suppressed oxidative stress and deregulated activation of inflammatory mediators and tumorigenesis[4].
    The kidney cortex of vehicle-treated control OVE26 mice displayed greater Nox4 expression and twice as much superoxide production than cortex of silybin-treated mice. The glomeruli of control OVE26 mice displayed 35% podocyte drop out that was not present in the silybin-treated mice[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    482.44

    Formula

    C₂₅H₂₂O₁₀

    CAS No.

    22888-70-6

    SMILES

    O=C1[[email protected]](O)[[email protected]@H](C2=CC=C(O[[email protected]](CO)[[email protected]@H](C3=CC=C(O)C(OC)=C3)O4)C4=C2)OC5=CC(O)=CC(O)=C15

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 100 mg/mL (207.28 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.0728 mL 10.3640 mL 20.7280 mL
    5 mM 0.4146 mL 2.0728 mL 4.1456 mL
    10 mM 0.2073 mL 1.0364 mL 2.0728 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.18 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    SilibininSilibinin A Silymarin IAutophagyReactive Oxygen SpeciesInhibitorinhibitorinhibit

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    Cat. No.:
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