Thailanstatin B

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Thailanstatin B is a potent pre-mRNA splicing inhibitor (IC₅₀=6.18 μM). Thailanstatin B shows antiproliferative activity.

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Thailanstatin B Chemical Structure

CAS No. : 1426953-23-2

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Biological Activity
Purity & Documentation
References
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Description

Thailanstatin B is a potent pre-mRNA splicing inhibitor (IC₅₀=6.18 μM). Thailanstatin B shows antiproliferative activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human BT474 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
DU-145	GI₅₀	3 nM Compound: 2	Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human DU145 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
HEK293	IC₅₀	6.18 μM Compound: 2	Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay Inhibition of Pre-mRNA splicing in human HEK293 cells using p32-labeled CDC14-15 pre-mRNA by exonjunction complex (EJC) immunoprecipitation assay	[PMID: 23517093]
HEK-293T	IC₅₀	193.7 nM Compound: 6	Cytotoxicity against HEK293T cells assessed as inhibition in cell growth Cytotoxicity against HEK293T cells assessed as inhibition in cell growth	[PMID: 33974423]
MDA-MB-231	GI₅₀	6.22 nM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]
MDA-MB-468	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human MDA-MB-468 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
MES-SA	IC₅₀	856.3 nM Compound: 6	Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA cells assessed as inhibition in cell growth	[PMID: 33974423]
MES-SA/Dx5	IC₅₀	>1000 nM Compound: 6	Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth	[PMID: 33974423]
MES-SA/Dx5	IC₅₀	>1 μM Compound: 6	Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth Cytotoxicity against human MES-SA/Dx5 cells assessed as inhibition in cell growth	[PMID: 33974423]
NCI-N87	IC₅₀	>100 nM Compound: 10	Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay Cytotoxicity against human NCI-N87 cells after 4 days by MTS/cell proliferation assay	[PMID: 25098528]
SK-OV-3	GI₅₀	4.94 nM Compound: 2	Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay Antiproliferative activity against human SKOV3 cells assessed as growth inhibition measured after 48 hrs by MTT assay	[PMID: 23517093]

In Vitro

Thailanstatin B exhibits potent antiproliferative activities with GI₅₀s 2.5-4.94 nM for DU-145, NCI-H232A, MDA-MB-231 and SKOV-3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

572.09

Formula

C₂₈H₄₂ClNO₉

CAS No.

1426953-23-2

SMILES

C[C@@H](C[C@H]([C@H](O1)C)NC(/C=C\[C@H](C)OC(C)=O)=O)[C@@H]1C/C=C(C)/C=C/[C@@H]2[C@H]([C@@](O)(C[C@H](O2)CC(O)=O)CCl)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Liu X, et al. Genomics-guided discovery of thailanstatins A, B, and C As pre-mRNA splicing inhibitors and antiproliferative agents from Burkholderia thailandensis MSMB43. J Nat Prod. 2013;76(4):685-693. [Content Brief]

Thailanstatin B Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thailanstatin B1426953-23-2DNA/RNA Synthesispre-mRNAsplicingantiproliferativecancerInhibitorinhibitorinhibit

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