2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. TPN729

TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction.

For research use only. We do not sell to patients.

TPN729 Chemical Structure

TPN729 Chemical Structure

CAS No. : 936951-20-1

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TPN729 Related Antibodies

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Description

TPN729 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 value of 2.28 nM. TPN729 affects erectile function and it can be used for the research of erectile dysfunction[1].

IC50 & Target

PDE5

2.28 nM (IC50)

PDE6

45.2 nM (IC50)

PDE1

566 nM (IC50)

PDE4

834 nM (IC50)

PDE11

6090 nM (IC50)

In Vivo

TPN729 (1.25, 2.5 and 5.0 mg/kg; intraduodenal injection, once) increases intracavernous pressure/blood pressure (ICP/BP) with the dose of 5.0 mg/kg at all time points and with the dose of 2.5 mg/kg at 75, 90, 105, and 120 minutes time points[1].
TPN729 (5.0 μg/kg; i.v., once) significantly increases ICP and ICP/BP of male Beagle dogs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats with corpora cavernosa complete exposure[1]
Dosage: 1.25, 2.5 and 5.0 mg/kg
Administration: Intraduodenal (i.d.) injection; 1.25, 2.5 and 5.0 mg/kg, once
Result: Dose-dependently increased the maximum intracavernous pressure (ICP) and ICP/blood pressure (BP).
Molecular Weight

516.66

Formula

C25H36N6O4S
CAS No.
SMILES

O=S(C1=CC=C(OCCC)C(C(NC2=C3N(C)N=C2CCC)=NC3=O)=C1)(N(C)CCN4CCCC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TPN729 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TPN729936951-20-1TPN 729TPN-729Phosphodiesterase (PDE)selectiveICPICP/BPdogratInhibitorinhibitorinhibit

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HY-116808
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