2. Anti-infection Cell Cycle/DNA Damage
  3. HBV DNA/RNA Synthesis
  4. trans-ccc_R08

trans-ccc_R08 (Compound 1-B) is a cccDNA inhibitor with anti-HBV activity, with an IC50 of 0.14 μM for HBeAg and an IC50 of 0.08 μM for HBsAg in in vitro assays. trans-ccc_R08 inhibits covalently closed circular DNA (cccDNA). trans-ccc_R08 is applicable to research related to hepatitis B virus infection.

For research use only. We do not sell to patients.

trans-ccc_R08

trans-ccc_R08 Chemical Structure

CAS No. : 2413192-49-9

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of trans-ccc_R08:

trans-ccc_R08 Related Antibodies

Top Publications Citing Use of Products

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms
RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

trans-ccc_R08 (Compound 1-B) is a cccDNA inhibitor with anti-HBV activity, with an IC50 of 0.14 μM for HBeAg and an IC50 of 0.08 μM for HBsAg in in vitro assays. trans-ccc_R08 inhibits covalently closed circular DNA (cccDNA). trans-ccc_R08 is applicable to research related to hepatitis B virus infection[1].

In Vitro

trans-ccc_R08 inhibits HBeAg production in HepDES19 cells with an IC50 of 0.14 μM[1].
trans-ccc_R08 inhibits HBsAg production in cryopreserved primary hepatocytes, with an IC50 of 0.08 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

trans-ccc_R08 Related Antibodies
Molecular Weight

414.84

Formula

C22H19ClO6
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1C=C(C2=CC=C(C=C2)OCCO[C@@H]3C[C@H](C3)C(O)=O)OC4=C(Cl)C=CC=C41
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (241.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4106 mL 12.0528 mL 24.1057 mL
5 mM 0.4821 mL 2.4106 mL 4.8211 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4106 mL 12.0528 mL 24.1057 mL 60.2642 mL
5 mM 0.4821 mL 2.4106 mL 4.8211 mL 12.0528 mL
10 mM 0.2411 mL 1.2053 mL 2.4106 mL 6.0264 mL
15 mM 0.1607 mL 0.8035 mL 1.6070 mL 4.0176 mL
20 mM 0.1205 mL 0.6026 mL 1.2053 mL 3.0132 mL
25 mM 0.0964 mL 0.4821 mL 0.9642 mL 2.4106 mL
30 mM 0.0804 mL 0.4018 mL 0.8035 mL 2.0088 mL
40 mM 0.0603 mL 0.3013 mL 0.6026 mL 1.5066 mL
50 mM 0.0482 mL 0.2411 mL 0.4821 mL 1.2053 mL
60 mM 0.0402 mL 0.2009 mL 0.4018 mL 1.0044 mL
80 mM 0.0301 mL 0.1507 mL 0.3013 mL 0.7533 mL
100 mM 0.0241 mL 0.1205 mL 0.2411 mL 0.6026 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

trans-ccc_R08 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-ccc_R082413192-49-9HBVDNA/RNA SynthesisHepatitis B virusviral DNA generationHBeAgcovalently closed circular DNAviral RNA transcriptionHBV infectionHepDES19 cellshepatitis b virus infectionprimary human hepatocytesHBsAgInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
trans-ccc_R08
Cat. No.:
HY-148560A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Korean - KR (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.