trans-Zeatin-d5
Based on 1 Customer Validation
trans-Zeatin-d5 is deuterium labeled trans-Zeatin. trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 72963-19-0
- Formula: C10H8D5N5O
- Molecular Weight:224.27
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 72963-19-0
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Unlabeled Cas 1637-39-4
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Appearance Solid
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Molecular Weight 224.27
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Formula C10H8D5N5O
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Color White to off-white
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SMILES
OC([2H])([2H])/C(C([2H])([2H])[2H])=C/CNC1=C2C(N=CN2)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 25 mg/mL (111.47 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Li Q, et al. Endogenous trans-zeatin content in plants with different metal-accumulating ability: a field survey. Environ Sci Pollut Res Int. 2016 Dec;23(23):23422-23435. Epub 2016 Sep 9. [Content Brief]
[3]. Ji C, et al. Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. Int J Mol Med. 2010 Aug;26(2):257-63. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.4589 mL | 22.2946 mL | 44.5891 mL | 111.4728 mL |
| 5 mM | 0.8918 mL | 4.4589 mL | 8.9178 mL | 22.2946 mL | |
| 10 mM | 0.4459 mL | 2.2295 mL | 4.4589 mL | 11.1473 mL | |
| 15 mM | 0.2973 mL | 1.4863 mL | 2.9726 mL | 7.4315 mL | |
| 20 mM | 0.2229 mL | 1.1147 mL | 2.2295 mL | 5.5736 mL | |
| 25 mM | 0.1784 mL | 0.8918 mL | 1.7836 mL | 4.4589 mL | |
| 30 mM | 0.1486 mL | 0.7432 mL | 1.4863 mL | 3.7158 mL | |
| 40 mM | 0.1115 mL | 0.5574 mL | 1.1147 mL | 2.7868 mL | |
| 50 mM | 0.0892 mL | 0.4459 mL | 0.8918 mL | 2.2295 mL | |
| 60 mM | 0.0743 mL | 0.3716 mL | 0.7432 mL | 1.8579 mL | |
| 80 mM | 0.0557 mL | 0.2787 mL | 0.5574 mL | 1.3934 mL | |
| 100 mM | 0.0446 mL | 0.2229 mL | 0.4459 mL | 1.1147 mL |
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