1. MAPK/ERK Pathway
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. MEK
    ERK
    Endogenous Metabolite
  3. trans-Zeatin

trans-Zeatin 

Cat. No.: HY-19700 Purity: 99.54%
Handling Instructions

trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.

For research use only. We do not sell to patients.

trans-Zeatin Chemical Structure

trans-Zeatin Chemical Structure

CAS No. : 1637-39-4

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10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division; trans-Zeatin also inhibits UV-induced MEK/ERK activation.

IC50 & Target

MEK

 

ERK

 

Human Endogenous Metabolite

 

In Vitro

trans-Zeatin is a plant cytokinin, which plays an important role in cell growth, differentiation, and division[1]. trans-Zeatin (20, 40 or 80 μM) inhibits UV-induced MEK/ERK activation, upregulates AQP3 in a time- and dose-dependent manner, and attenuates UV induced loss of AQP3 in keratinocytes (HaCaT cells). UV-induced AQP3 downregulation is blocked by MEK/ERK inhibitors. Trans-Zeatin (80 μM) attenuates UV-induced downregulation of wound healing and water permeability in HaCaT cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

219.24

Formula

C₁₀H₁₃N₅O

CAS No.

1637-39-4

SMILES

OC/C(C)=C/CNC1=C2N=CNC2=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (114.03 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5612 mL 22.8061 mL 45.6121 mL
5 mM 0.9122 mL 4.5612 mL 9.1224 mL
10 mM 0.4561 mL 2.2806 mL 4.5612 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (9.49 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (9.49 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (9.49 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

trans-ZeatinMEKERKEndogenous MetaboliteMitogen-activated protein kinase kinaseMAPKKMAP2KExtracellular signal regulated kinasesInhibitorinhibitorinhibit

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Product Name:
trans-Zeatin
Cat. No.:
HY-19700
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