Ebsulfur
Based on 1 Customer Validation
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC50 values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis.
For research use only. We do not sell to patients.
- Purity: 99.43%
- CAS No.: 2527-03-9
- Formula: C13H9NOS
- Molecular Weight:227.28
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
>32 μM
Compound: 1b
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Cytotoxicity against human HaCaT cells
Cytotoxicity against human HaCaT cells
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[PMID: 35099959] |
| Vero C1008 | CC50 |
19.43 μM
Compound: 1.1
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Cytotoxicity against monkey Vero C1008 cells after 72 hrs by MTT assay
Cytotoxicity against monkey Vero C1008 cells after 72 hrs by MTT assay
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[PMID: 28159413] |
Chemical Information
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CAS No. 2527-03-9
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Appearance Solid
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Molecular Weight 227.28
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Formula C13H9NOS
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Color White to off-white
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SMILES
O=C1N(C2=CC=CC=C2)SC3=C1C=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 62.5 mg/mL (274.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3999 mL | 21.9993 mL | 43.9986 mL | 109.9965 mL |
| 5 mM | 0.8800 mL | 4.3999 mL | 8.7997 mL | 21.9993 mL | |
| 10 mM | 0.4400 mL | 2.1999 mL | 4.3999 mL | 10.9996 mL | |
| 15 mM | 0.2933 mL | 1.4666 mL | 2.9332 mL | 7.3331 mL | |
| 20 mM | 0.2200 mL | 1.1000 mL | 2.1999 mL | 5.4998 mL | |
| 25 mM | 0.1760 mL | 0.8800 mL | 1.7599 mL | 4.3999 mL | |
| 30 mM | 0.1467 mL | 0.7333 mL | 1.4666 mL | 3.6665 mL | |
| 40 mM | 0.1100 mL | 0.5500 mL | 1.1000 mL | 2.7499 mL | |
| 50 mM | 0.0880 mL | 0.4400 mL | 0.8800 mL | 2.1999 mL | |
| 60 mM | 0.0733 mL | 0.3667 mL | 0.7333 mL | 1.8333 mL | |
| 80 mM | 0.0550 mL | 0.2750 mL | 0.5500 mL | 1.3750 mL | |
| 100 mM | 0.0440 mL | 0.2200 mL | 0.4400 mL | 1.1000 mL |
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