BTRC - beta-transducin repeat containing E3 ubiquitin protein ligase Gene

Also Known as FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8945

About BTRC

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,354,048-101,557,313 (from NCBI)

This gene has 7 transcripts (splice variants), 140 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 11.6), testis (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

BTRC Products (3)

mRNA	Protein	Name
NM_001256856.2	NP_001243785.1	F-box/WD repeat-containing protein 1A isoform 3
NM_003939.5	NP_003930.1	F-box/WD repeat-containing protein 1A isoform 2
NM_033637.4	NP_378663.1	F-box/WD repeat-containing protein 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	12820959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9859996	GOA
enables ubiquitin ligase activator activity	IDA IDA: Inferred from direct assay	12820959	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	10066435	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22017875	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	38225265	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10066435	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	12820959	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15917222	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	38225265	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	12820959	GOA
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	12820959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16885022	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	21258371	GOA
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	15917222	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15448698	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12820959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTRC Protein Structure

Beta-TrCP_D

F-box-like

WD40

0
100
200
300
400
500
605 a.a.

Protein Preferred Names	Protein Names
F-box/WD repeat-containing protein 1A	E3RSIkappaB

BTRC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BTRC	Q9Y297	IL10RA	Homo sapiens	Q13651	Y2H Prey Pooling	32296183
Intra	BTRC	Q9Y297	IL10RA	Homo sapiens	Q13651	Y2H Array	32296183
Intra	BTRC	Q9Y297	YAP1	Homo sapiens	P46937	Y2H	21900206
Intra	BTRC	Q9Y297	YAP1	Homo sapiens	P46937	Anti Tag CoIP	33961781
Intra	BTRC	Q9Y297	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	BTRC	Q9Y297	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	BTRC	Q9Y297	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410-7	Validated Y2H	26871637
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410-7	Y2H Array	26871637
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410-7	Y2H Array	32296183
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	26871637
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410-7	Y2H Prey Pooling	32296183
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026-5	Y2H Array	31515488
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026-5	Validated Y2H	26871637
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026-5	Y2H Prey Pooling	26871637
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026-5	Y2H Array	26871637
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	Lumier	37398436
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	CoIP	10644755
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	Anti Tag CoIP	15070733
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	Anti Tag CoIP	22632967
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	Pull Down	9660940
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	BRET	37398436
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	CoIP	12609982
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	Anti Tag CoIP	33961781
Intra	BTRC	Q9Y297	SKP1	Homo sapiens	P63208	MAPPIT	19159283
Intra	BTRC	Q9Y297	DLG1	Homo sapiens	Q12959	Anti Bait CoIP	12902344
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	CoIP	12609982
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	19615732
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	CoIP	10644755
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	21145461
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781
Intra	BTRC	Q9Y297	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	18354482
Intra	BTRC	Q9Y297	TP53	Homo sapiens	P04637	Anti Tag CoIP	19196987
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0	Validated Y2H	25416956
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0	Y2H Prey Pooling	25416956
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0	Y2H Array	25416956
Intra	BTRC	Q9Y297	MDM2	Homo sapiens	Q00987	Pull Down	20708156
Intra	BTRC	Q9Y297	MDM2	Homo sapiens	Q00987	Anti Tag CoIP	20708156
Intra	BTRC	Q9Y297	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	BTRC	Q9Y297	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	BTRC	Q9Y297	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	BTRC	Q9Y297	COPS6	Homo sapiens	Q7L5N1	Anti Bait CoIP	26267535
Intra	BTRC	Q9Y297	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	20531388
Intra	BTRC	Q9Y297	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	16376880
Intra	BTRC	Q9Y297	CTNNB1	Homo sapiens	P35222	Anti Tag CoIP	20531388
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	21988832
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Confocal	21988832
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H	21988832
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	31515488
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	26871637
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Validated Y2H	25416956
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Prey Pooling	32296183
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Validated Y2H	26871637
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	25416956
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	26871637
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	32296183
Intra	BTRC	Q9Y297	ATF4	Homo sapiens	P18848	Y2H Array	29892012
Intra	BTRC	Q9Y297	MAP2K1	Homo sapiens	Q02750	Anti Tag CoIP	24211253
Intra	BTRC	Q9Y297	AMER1	Homo sapiens	Q5JTC6	Anti Tag CoIP	33961781
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410	Y2H Prey Pooling	25416956
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410	Validated Y2H	25416956
Intra	BTRC	Q9Y297	TACC1	Homo sapiens	O75410	Y2H Array	25416956
Intra	BTRC	Q9Y297	NEDD8	Homo sapiens	Q15843	Anti Bait CoIP	17318178
Intra	BTRC	Q9Y297	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	BTRC	Q9Y297	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	BTRC	Q9Y297	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Validated Y2H	25416956
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Y2H Prey Pooling	32296183
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Y2H Array	25416956
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Anti Tag CoIP	33961781
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Y2H Array	32296183
Intra	BTRC	Q9Y297	TRIM9	Homo sapiens	Q9C026	Y2H Pooling	16189514
Intra	BTRC	Q9Y297	NFE2	Homo sapiens	Q16621	Y2H Array	25416956
Intra	BTRC	Q9Y297	PLK4	Homo sapiens	O00444	Y2H Prey Pooling	26871637
Intra	BTRC	Q9Y297	PLK4	Homo sapiens	O00444	Y2H Array	26871637
Intra	BTRC	Q9Y297	PLK4	Homo sapiens	O00444	Anti Tag CoIP	25503564
Intra	BTRC	Q9Y297	PLK4	Homo sapiens	O00444	Validated Y2H	26871637
Intra	BTRC	Q9Y297	WWTR1	Homo sapiens	Q9GZV5	Anti Bait CoIP	22078877
Intra	BTRC	Q9Y297	ZC3H12A	Homo sapiens	Q5D1E8	Y2H	21988832
Intra	BTRC	Q9Y297	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
Intra	BTRC	Q9Y297	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
Intra	BTRC	Q9Y297	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
Intra	BTRC	Q9Y297	INAVA	Homo sapiens	Q3KP66	Anti Tag CoIP	29420262
Intra	BTRC	Q9Y297	WEE1	Homo sapiens	P30291	Anti Tag CoIP	15070733
Intra	BTRC	Q9Y297	REST	Homo sapiens	Q13127	Anti Tag CoIP	18354482
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0-2	Y2H Prey Pooling	26871637
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0-2	Validated Y2H	26871637
Intra	BTRC	Q9Y297	RASSF5	Homo sapiens	Q8WWW0-2	Y2H Array	26871637
Cross	BTRC	Q9Y297	Dlg1	Rattus norvegicus	Q62696	Anti Tag CoIP	12902344

Cross: Cross-species interaction Intra: Intraspecies interaction

BTRC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84888	BTRC Antibody (YA4585)	WB, IHC-P, FC, ELISA	Human
HY-P84888A	BTRC Antibody (YA4585)(PBS only)	WB, IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Isolated Split Hand-Split Foot Malformation	Ectrodactyly Shfm Split Hand Foot Malformation Split-Hand/Foot Malformation Split Hand Foot Deformity 1 Split Hand Foot Deformity
Vaccinia
Adult Liposarcoma
Split-Hand/Foot Malformation 3	SHFM3 Split Hand-Foot Malformation 3 Chromosome 10q24 Duplication Syndrome Shsf3 Limb Deficiencies, Distal, With Micrognathia Split-Hand/Foot Malformation 3, Gene Duplication Syndrome Distal Limb Deficiencies With Micrognathia Limb Deficiencies Distal With Micrognathia Buttiens Fryns Syndrome Distal Limb Deficiencies-Micrognathia Syndrome 10q24 Microduplication Syndrome Buttiens-Fryns Syndrome Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Split Hand-Foot Malformation	Ectrodactyly Split-Hand/Foot Malformation Lobster-Claw Deformity Split-Hand Deformity Split Hand Foot Malformation Shfm Split Hand Foot Deformity Split Hand Foot Deformity 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01680	BTRC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20699	Btrc Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27210	Btrc Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P99896	Runimotamab		99.00%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BTRC	RGD	RGD:1359721
Mus musculus	BTRC	MGD	MGI:1338871
Canis familiaris	BTRC	VGNC	VGNC:38564
Macaca mulatta	BTRC	VGNC	VGNC:100303
Bos taurus	BTRC	VGNC	VGNC:26603
Others	BTRC	NCBI