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Cat. No.: HY-174994

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JY-5

JY-5 is an E3 ligase ligand that can bind to TRIM28, RACK1, LMO7 and FUS. JY-5 can be used for synthesis of PROTAC JY-21 (HY-174975).

For research use only. We do not sell to patients.

Formula: C₂₀H₂₇N₃O₃Si
Molecular Weight:385.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

JY-5 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

JY-5 is an E3 ligase ligand that can bind to TRIM28, RACK1, LMO7 and FUS. JY-5 can be used for synthesis of PROTAC JY-21 (HY-174975)^[1].

All Ligands for E3 Ligase Isoforms :

Chemical Information

Molecular Weight 385.53
Formula C₂₀H₂₇N₃O₃Si
SMILES

CC(C)[Si](C(C)C)(C(C)C)C#C/N=N/C(C([N+]([O-])=O)=C1)=CC=C1OCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Du J,et al. Azoacetylene Electrophiles for Proteome-wide Ligand and Target Discovery: Supporting Targeted Protein Degradation. J Med Chem. 2025 Jul 10;68(13):13516-13531. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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JY-5

All Ligands for E3 Ligase Isoforms

Biological Activity

Description

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JY-5 Related Classifications

HY-174994 Related Classifications

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Keywords

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