PRMT5-IN-2
Based on 1 Customer Validation
PRMT5-IN-2 is a rotein arginine methyltransferase 5 (PRMT5) inhibitor extracted from patent WO2018130840A1, compound 3.
For research use only. We do not sell to patients.
- Purity: 98.68%
- CAS No.: 1989620-04-3
- Formula: C17H16ClFN4O4
- Molecular Weight:394.78
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Epigenetics Compound Library
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Reprogramming Compound Library
HY-L039
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Anti-Blood Cancer Compound Library
HY-L079
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Heterocyclic Compound Library
HY-L138
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Anti-Hematopathy Compound Library
HY-L171
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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Methylation Compound Library
HY-L203
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
All Histone Methyltransferase Isoforms
More
Biological Activity
PRMT5[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Z-138 | IC50 |
1.4 nM
Compound: PF-0685580; 4
|
Antiproliferative activity against human Z138 cells
Antiproliferative activity against human Z138 cells
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[PMID: 30956011] |
Chemical Information
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CAS No. 1989620-04-3
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Appearance Solid
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Molecular Weight 394.78
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Formula C17H16ClFN4O4
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Color Off-white to light yellow
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SMILES
O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC(F)=C(Cl)C=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (316.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5331 mL | 12.6653 mL | 25.3306 mL | 63.3264 mL |
| 5 mM | 0.5066 mL | 2.5331 mL | 5.0661 mL | 12.6653 mL | |
| 10 mM | 0.2533 mL | 1.2665 mL | 2.5331 mL | 6.3326 mL | |
| 15 mM | 0.1689 mL | 0.8444 mL | 1.6887 mL | 4.2218 mL | |
| 20 mM | 0.1267 mL | 0.6333 mL | 1.2665 mL | 3.1663 mL | |
| 25 mM | 0.1013 mL | 0.5066 mL | 1.0132 mL | 2.5331 mL | |
| 30 mM | 0.0844 mL | 0.4222 mL | 0.8444 mL | 2.1109 mL | |
| 40 mM | 0.0633 mL | 0.3166 mL | 0.6333 mL | 1.5832 mL | |
| 50 mM | 0.0507 mL | 0.2533 mL | 0.5066 mL | 1.2665 mL | |
| 60 mM | 0.0422 mL | 0.2111 mL | 0.4222 mL | 1.0554 mL | |
| 80 mM | 0.0317 mL | 0.1583 mL | 0.3166 mL | 0.7916 mL | |
| 100 mM | 0.0253 mL | 0.1267 mL | 0.2533 mL | 0.6333 mL |
PRMT5-IN-2 Related Classifications
HY-112165 Related Classifications
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