Wistin
Based on 1 Customer Validation
Wistin, isolated from Caragana sinica roots, is a PPARα and PPARγ agonist.
For research use only. We do not sell to patients.
- Purity: 97.63%
- CAS No.: 19046-26-5
- Formula: C23H24O10
- Molecular Weight:460.43
-
Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Wistin, is a PPARγ agonist that can induce the mRNA expression of the PPARγ target gene adiponectin in mouse 3T3-L1 cells[2].
Wistin inhibits cellular triglyceride accumulation in hepatocytes (P<0.05 at 10 μg/mL) in a dose-dependent manner[2].
Wistin (10 μg/mL) results in a 2.5-, 7.2-, and 14.8-fold increase in the expression levels of CPT1a, ACO, and ACS, respectively[2].
Treatment with Wistin for 48 h significantly decreases the amount of cellular TG in mouse primary hepatocytes in a dose-dependent manner[2].
Treatment with wistin enhanced the marker of adipocyte differentiation, such as triglyceride accumulation in 3T3-L1 cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Mouse hepatocytes.
-
Concentration:1 or 10 μg/mL.
-
Incubation Time:48 h.
-
Result:Significantly increased PPARα mRNA levels in a dose-dependent manner.
Chemical Information
-
CAS No. 19046-26-5
-
Appearance Solid
-
Molecular Weight 460.43
-
Formula C23H24O10
-
Color White to off-white
-
SMILES
O=C1C2=CC(OC)=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)CO)C=C2OC=C1C4=CC=C(C=C4)OC
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. SeonJu Park, et al. Neuraminidase Inhibitors from the Roots of Caragana sinica. Chem Biodivers. 2020 Nov;17(11):e2000470. [Content Brief]
[2]. Misato Suzuki, et al. 4',6-Dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor α (PPARα) agonist in mouse hepatocytes. Mol Cell Biochem. 2018 Sep;446(1-2):35-41. [Content Brief]
[3]. Matoki Sanada, et al. 4',6-dimethoxyisoflavone-7-O-β-D-glucopyranoside (wistin) is a peroxisome proliferator-activated receptor γ (PPARγ) agonist that stimulates adipocyte differentiation. Anim Sci J. 2016 Nov;87(11):1347-1351. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Wistin Related Classifications
HY-N9333 Related Classifications
Powered by Bioz