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Cat. No.: HY-147792

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WNY1613

WNY1613 is a potent and selective PI3Kδ inhibitor with piperazinone-containing purine scaffold. WNY1613 induces cancer cell apoptosis and inhibits the phosphorylation of PI3K downstream components in NHL cell lines. WNY1613 exhibits anti-NHL activity in vitro and in vivo.

For research use only. We do not sell to patients.

CAS No.: 2650546-39-5
Formula: C₂₉H₃₅N₉O₃
Molecular Weight:557.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WNY1613 Chemical Structure

CAS No.: 2650546-39-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Granta-519	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
JeKo-1	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
NAMALVA	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
OCI-Ly3	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SUD4	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SU-DHL-6	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
WSUDLCL2	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]

Chemical Information

CAS No. 2650546-39-5
Molecular Weight 557.65
Formula C₂₉H₃₅N₉O₃
SMILES

O=C1N(CC2=NC3=C(N4CCOCC4)N=C(N5C6=CC=CC=C6N=C5CC)N=C3N2C)CCN(C(C7CCC7)=O)C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zuo WQ, et al. Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma. Bioorg Chem. 2020;105:104344. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
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Purity & Documentation
References

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WNY1613

All PI3K Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WNY1613 Related Classifications

HY-147792 Related Classifications