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Cat. No.: HY-147792

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WNY1613

WNY1613 is a potent and selective PI3Kδ inhibitor with piperazinone-containing purine scaffold. WNY1613 induces cancer cell apoptosis and inhibits the phosphorylation of PI3K downstream components in NHL cell lines. WNY1613 exhibits anti-NHL activity in vitro and in vivo.

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CAS No.: 2650546-39-5
Formule: C₂₉H₃₅N₉O₃
Masse moléculaire:557.65

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

WNY1613 Chemical Structure

CAS No.: 2650546-39-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform PI3K :

Cellular Effect

Cell Line	Type	Value	Description	References
Granta-519	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human Granta-519 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
JeKo-1	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human JeKo-1 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
NAMALVA	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human NAMALVA cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
OCI-Ly3	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human OCILY3 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SUD4	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-4 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
SU-DHL-6	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human SU-DHL-6 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]
WSUDLCL2	IC₅₀	0.038 μM Compound: 30; WNY1613	Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay Antiproliferative activity against human WSUDLCL2 cells assessed as cell viability by non-radioactive cell proliferation MTT assay	[PMID: 36503229]

Chemical Information

CAS No. 2650546-39-5
Masse moléculaire 557.65
Formule C₂₉H₃₅N₉O₃
SMILES

O=C1N(CC2=NC3=C(N4CCOCC4)N=C(N5C6=CC=CC=C6N=C5CC)N=C3N2C)CCN(C(C7CCC7)=O)C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zuo WQ, et al. Identification of a potent and selective phosphatidylinositol 3-kinase δ inhibitor for the treatment of non-Hodgkin's lymphoma. Bioorg Chem. 2020;105:104344. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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WNY1613

Voir tous les produits spécifiques à Isoform PI3K