γ-Tocopherol-d4
Based on 1 Customer Validation
γ-Tocopherol-d4 is the deuterium labeled γ-Tocopherol. γ-Tocopherol (D-γ-Tocopherol) is a potent cyclooxygenase (COX) inhibitor. γ-Tocopherol is a naturally occurring form of Vitamin E in many plant seeds, such as corn oil and soybeans. γ-Tocopherol possesses antiinflammatory properties and anti-cancer activity.
For research use only. We do not sell to patients.
- Purity: 98.90%
- CAS No.: 1329652-13-2
- Formula: C28H44D4O2
- Molecular Weight:420.70
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1329652-13-2
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Unlabeled Cas 54-28-4
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Appearance Oil
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Molecular Weight 420.70
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Formula C28H44D4O2
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Color Colorless to light yellow
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SMILES
CC1=C2C(CC[C@](C)(O2)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C([2H])C(O)=C1C([2H])([2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (237.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Q Jiang, et al. Gamma-Tocopherol, the Major Form of Vitamin E in the US Diet, Deserves More Attention. Am J Clin Nutr. 2001 Dec;74(6):714-22. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3770 mL | 11.8850 mL | 23.7699 mL | 59.4248 mL |
| 5 mM | 0.4754 mL | 2.3770 mL | 4.7540 mL | 11.8850 mL | |
| 10 mM | 0.2377 mL | 1.1885 mL | 2.3770 mL | 5.9425 mL | |
| 15 mM | 0.1585 mL | 0.7923 mL | 1.5847 mL | 3.9617 mL | |
| 20 mM | 0.1188 mL | 0.5942 mL | 1.1885 mL | 2.9712 mL | |
| 25 mM | 0.0951 mL | 0.4754 mL | 0.9508 mL | 2.3770 mL | |
| 30 mM | 0.0792 mL | 0.3962 mL | 0.7923 mL | 1.9808 mL | |
| 40 mM | 0.0594 mL | 0.2971 mL | 0.5942 mL | 1.4856 mL | |
| 50 mM | 0.0475 mL | 0.2377 mL | 0.4754 mL | 1.1885 mL | |
| 60 mM | 0.0396 mL | 0.1981 mL | 0.3962 mL | 0.9904 mL | |
| 80 mM | 0.0297 mL | 0.1486 mL | 0.2971 mL | 0.7428 mL | |
| 100 mM | 0.0238 mL | 0.1188 mL | 0.2377 mL | 0.5942 mL |
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