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Cat. No.: HY-164372

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17-Demethoxy-reblastatin

(Synonyms: 17-DR)

17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC₅₀ of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway.

For research use only. We do not sell to patients.

CAS No.: 299173-64-1
Formula: C₂₈H₄₂N₂O₇
Molecular Weight:518.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

17-Demethoxy-reblastatin Chemical Structure

CAS No.: 299173-64-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All HSP Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	GI₅₀	2.73 μM Compound: 4, EH21A2	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	[PMID: 18243703]
CWR22R	IC₅₀	35 μM Compound: 6	Cytotoxicity against human 22Rv1 cells Cytotoxicity against human 22Rv1 cells	[PMID: 34225450]
DLD-1	GI₅₀	2.35 μM Compound: 4, EH21A2	Growth inhibition of human DLD1 cells Growth inhibition of human DLD1 cells	[PMID: 18243703]
HCT-116	GI₅₀	0.78 μM Compound: 4, EH21A2	Growth inhibition of human HCT116 cells Growth inhibition of human HCT116 cells	[PMID: 18243703]
K562	EC₅₀	1.9 μM Compound: 4, EH21A2	Induction of human K562 cells differentiation Induction of human K562 cells differentiation	[PMID: 18243703]
LNCaP C4-2B	IC₅₀	32 μM Compound: 6	Cytotoxicity against human C42B cells Cytotoxicity against human C42B cells	[PMID: 34225450]
MDA-MB-231	IC₅₀	>40 μM Compound: 6	Cytotoxicity against human MDA-MB-231 cells Cytotoxicity against human MDA-MB-231 cells	[PMID: 34225450]
MDA-MB-231	IC₅₀	74.9 μM Compound: 46; 17-DR	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition	[PMID: 33650861]
MGC-803	IC₅₀	>40 μM Compound: 6	Cytotoxicity against human MGC-803 cells Cytotoxicity against human MGC-803 cells	[PMID: 34225450]
NCI-H446	IC₅₀	28 μM Compound: 6	Cytotoxicity against human H446 cells Cytotoxicity against human H446 cells	[PMID: 34225450]

Chemical Information

CAS No. 299173-64-1
Molecular Weight 518.64
Formula C₂₈H₄₂N₂O₇
SMILES

C[C@@H](/C=C1C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=CC(O)=CC(NC(/C(C)=C/CC[C@H](OC)[C@H]\1OC(N)=O)=O)=C2
Synonyms

17-DR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao S, et al., 17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells. J Bioenerg Biomembr. 2015 Oct;47(5):373-81. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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17-Demethoxy-reblastatin

All HSP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

17-Demethoxy-reblastatin Related Classifications

HY-164372 Related Classifications