2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease Apoptosis
  3. HSP Apoptosis
  4. 17-Demethoxy-reblastatin

17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway.

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17-Demethoxy-reblastatin

17-Demethoxy-reblastatin Chemical Structure

CAS No. : 299173-64-1

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17-Demethoxy-reblastatin Related Antibodies

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Description

17-Demethoxy-reblastatin (17-DR) is an inhibitor for heat shock protein 90 (Hsp90), with an IC50 of 1.82 μM for yeast Hsp90 ATPase. 17-Demethoxy-reblastatin inhibits the proliferation of cancer cell HepG2 and SMMC7721, reduces the colony formation, and induces apoptosis through mitochondria and caspase mediated pathway[1].

Cellular Effect
Cell Line Type Value Description References
A549 GI50
2.73 μM
Compound: 4, EH21A2
Growth inhibition of human A549 cells
Growth inhibition of human A549 cells
[PMID: 18243703]
CWR22R IC50
35 μM
Compound: 6
Cytotoxicity against human 22Rv1 cells
Cytotoxicity against human 22Rv1 cells
[PMID: 34225450]
DLD-1 GI50
2.35 μM
Compound: 4, EH21A2
Growth inhibition of human DLD1 cells
Growth inhibition of human DLD1 cells
[PMID: 18243703]
HCT-116 GI50
0.78 μM
Compound: 4, EH21A2
Growth inhibition of human HCT116 cells
Growth inhibition of human HCT116 cells
[PMID: 18243703]
K562 EC50
1.9 μM
Compound: 4, EH21A2
Induction of human K562 cells differentiation
Induction of human K562 cells differentiation
[PMID: 18243703]
LNCaP C4-2B IC50
32 μM
Compound: 6
Cytotoxicity against human C42B cells
Cytotoxicity against human C42B cells
[PMID: 34225450]
MDA-MB-231 IC50
74.9 μM
Compound: 46; 17-DR
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition
Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition
[PMID: 33650861]
MDA-MB-231 IC50
> 40 μM
Compound: 6
Cytotoxicity against human MDA-MB-231 cells
Cytotoxicity against human MDA-MB-231 cells
[PMID: 34225450]
MGC-803 IC50
> 40 μM
Compound: 6
Cytotoxicity against human MGC-803 cells
Cytotoxicity against human MGC-803 cells
[PMID: 34225450]
NCI-H446 IC50
28 μM
Compound: 6
Cytotoxicity against human H446 cells
Cytotoxicity against human H446 cells
[PMID: 34225450]
Molecular Weight

518.64

Formula

C28H42N2O7
CAS No.
SMILES

C[C@@H](/C=C1C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=CC(O)=CC(NC(/C(C)=C/CC[C@H](OC)[C@H]\1OC(N)=O)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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17-Demethoxy-reblastatin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

17-Demethoxy-reblastatin299173-64-117-DRHSPApoptosisHeat shock proteinsHepG2SMMC7721HCChuman hepatocellular carcinomaInhibitorinhibitorinhibit

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