1. Anti-infection
  2. Parasite

Fluralaner (Synonyms: A1443; AH252723)

Cat. No.: HY-16973 Purity: 99.87%
Data Sheet SDS Handling Instructions

Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

For research use only. We do not sell to patients.
Fluralaner Chemical Structure

Fluralaner Chemical Structure

CAS No. : 864731-61-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO $404 In-stock
1 mg $110 In-stock
5 mg $330 In-stock
10 mg $500 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels.

In Vitro

Fluralaner potently inhibits flea reproduction capacity in vitro. Oviposition ceases completely at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL)[1].

In Vivo

In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner completely controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment[1]. After single oral administration of Bravecto chewable tablets, mite numbers in skin scrapings are reduced by 99.8% on Day 28 and by 100% on Days 56 and 84. A marked decrease is observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravectco[2].

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.7976 mL 8.9881 mL 17.9762 mL
5 mM 0.3595 mL 1.7976 mL 3.5952 mL
10 mM 0.1798 mL 0.8988 mL 1.7976 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[2]

Dogs: Thirty-two (16 male and 16 female) healthy 8-week old Beagle dogs weighing 2.0 - 3.6 kg at first administration are included in the study. Fluralaner is administered on three occasions at 8-week intervals at doses of up to 56, 168, and 280 mg fluralaner/kg body weight, equivalent to 1, 3, and 5 times the highest recommended treatment dose of fluralaner; sham dosed dogs served as controls[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

556.29

Formula

C₂₂H₁₇Cl₂F₆N₃O₃

CAS No.

864731-61-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 221 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Fluralaner
Cat. No.:
HY-16973
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