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    Fungal
  3. Hygromycin B

Hygromycin B (Synonyms: Hygrovetine)

製品番号: HY-B0490 純度: >98.00%
取扱説明書

Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

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Hygromycin B 構造式

Hygromycin B 構造式

CAS 番号 : 31282-04-9

容量 価格(税別) 在庫状況 数量
無料サンプル (0.5-1 mg)   今すぐ申し込む  
10 mM * 1 mL in Water USD 66 在庫あり
Estimated Time of Arrival: December 31
200 mg USD 60 在庫あり
Estimated Time of Arrival: December 31
500 mg USD 84 在庫あり
Estimated Time of Arrival: December 31
1 g USD 108 在庫あり
Estimated Time of Arrival: December 31
5 g USD 396 在庫あり
Estimated Time of Arrival: December 31
10 g   お問い合わせ  
50 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 1 publication(s) in Google Scholar

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製品説明

Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

IC50 & Target

Target:Antibacterial; Antifungal[1]

体外実験

Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus[1]. Hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes. Polypeptide synthesis in cell-free extracts from rabbit reticulocytes, wheat germ and yeast is strongly blocked by low concentrations ofhygromycin B. The antibiotic inhibits peptide chain elongation by yeast polysomes by preventing elongation factor EF-2-dependent translocation. The inhibition of translocation by hygromycin B might result from the stabilization of peptidyl-tRNA bound to the ribosomal acceptor site[2].

体内実験

Hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading in vivo[3]. Constitutive expression of the bacterial hygR gene in transgenic mice in vivo confers resistance to hygromycin B[4].

分子量

527.52

分子式

C₂₀H₃₇N₃O₁₃

CAS 番号

31282-04-9

SMILES
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

H2O : ≥ 30 mg/mL (56.87 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8957 mL 9.4783 mL 18.9566 mL
5 mM 0.3791 mL 1.8957 mL 3.7913 mL
10 mM 0.1896 mL 0.9478 mL 1.8957 mL
*Please refer to the solubility information to select the appropriate solvent.
参考文献
動物実験
[4]

Hygromycin B is dissolved in sterile water. The mice C57BL/6J-TgN(pPWL512hyg)1Ems carrying hygR are treated with a single dose of hygromycin B i.p. at doses that starts at 2.7 mg/kg and increases by 50% for each consecutive dose. Control wild-type C57BL/6J mice are treated with the same volume of sterile saline. Total volume injected is 0.5 mL. The health status and body weights of animals are monitored daily for 10 consecutive days[4].

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参考文献

純度: >98.00%

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Keywords:

Hygromycin BHygrovetineBacterialFungalInhibitorinhibitorinhibit

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製品名:
Hygromycin B
製品番号:
HY-B0490
数量:
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