1. Cell Cycle/DNA Damage
  2. PPAR

MA-0204 

Cat. No.: HY-114739
Handling Instructions

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).

For research use only. We do not sell to patients.

MA-0204 Chemical Structure

MA-0204 Chemical Structure

CAS No. : 2095128-17-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1500 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].

IC50 & Target[1]

PPARδ

0.4 nM (EC50, in human)

PPARδ

7.9 nM (EC50, in mouse)

PPARδ

10 nM (EC50, in rat)

In Vitro

MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C[1].

MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice[1].

MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts[1].

In Vivo

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1].

Solvent & Solubility
In Vitro: 

DMSO : 43.33 mg/mL (90.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0987 mL 10.4934 mL 20.9868 mL
5 mM 0.4197 mL 2.0987 mL 4.1974 mL
10 mM 0.2099 mL 1.0493 mL 2.0987 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.55 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.17 mg/mL (4.55 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

476.49

Formula

C₂₅H₂₇F₃N₂O₄

CAS No.

2095128-17-7

SMILES

O=C(C[[email protected]@H](CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C=C3)OC(F)(F)F)C)O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MA-0204
Cat. No.:
HY-114739
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MA-0204

Cat. No.: HY-114739