1. Cell Cycle/DNA Damage
  2. PPAR
  3. MA-0204

MA-0204 

Cat. No.: HY-114739 Purity: 99.31%
Handling Instructions

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD).

For research use only. We do not sell to patients.

MA-0204 Chemical Structure

MA-0204 Chemical Structure

CAS No. : 2095128-17-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 398 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 398 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 380 In-stock
Estimated Time of Arrival: December 31
10 mg USD 640 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2600 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Description

MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. Potential treatment for Duchene Muscular Dystrophy (DMD)[1].

IC50 & Target

PPARδ

0.4 nM (EC50, in human)

PPARδ

7.9 nM (EC50, in mouse)

PPARδ

10 nM (EC50, in rat)

In Vitro

MA-0204 is >10,000-fold selective for activation of PPARδ over PPARα and PPARγ receptors. MA-0204 exhibits high protein binding to mouse plasma, good permeability and low potential for efflux. C[1].

MA-0204 (1.2-12 nM) improves fatty acid oxidation in DMD patient muscle myoblasts mice[1].

MA-0204 (0.04-40 nM) engages target gene expression in DMD patient muscle myoblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PPARδ (30, 100 mg/kg) increases target gene transcription in the muscle[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

476.49

Formula

C25H27F3N2O4

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 43.33 mg/mL (90.94 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0987 mL 10.4934 mL 20.9868 mL
5 mM 0.4197 mL 2.0987 mL 4.1974 mL
10 mM 0.2099 mL 1.0493 mL 2.0987 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.17 mg/mL (4.55 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (4.55 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
MA-0204
Cat. No.:
HY-114739
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