1. Apoptosis
  2. Bcl-2 Family

ML311 

Cat. No.: HY-101778
Handling Instructions

ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.

For research use only. We do not sell to patients.

ML311 Chemical Structure

ML311 Chemical Structure

CAS No. : 315698-17-0

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5 mg USD 100 Get quote
10 mg USD 160 Get quote
50 mg USD 560 Get quote
100 mg USD 960 Get quote

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

ML311 is a potent and selective inhibitor of the Mcl-1/Bim interaction.

IC50 & Target[1]

Mcl-1

 

Bim

 

In Vitro

ML311 potently halts viability of several types of Mcl-1 primed cells, including MCL-1-1780 (EC50=0.31 μM), DHL-6 (EC50=3.3 μM), and NCI-H929 (EC50=1.6 μM), with generally high maximal effect (>80%). ML311 also displays activity in a leukemia-derived cell line particularly reliant upon Bcl-2 function (Bcl2-1863, EC50=1.1 μM). ML311 has strong growth inhibitory effects in many cell lines, with GI50<900 nM for nine cell types (RPMI-8226, SR, NCI-H322M, NCI-H60, HCC-2998, KM12, SF-295, U251, PC-3 cell lines), and <2 μM for 14 additional types[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4070 mL 12.0351 mL 24.0703 mL
5 mM 0.4814 mL 2.4070 mL 4.8141 mL
10 mM 0.2407 mL 1.2035 mL 2.4070 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

415.45

Formula

C₂₃H₂₄F₃N₃O

CAS No.

315698-17-0

SMILES

OC1=C2N=CC=CC2=CC=C1C(N3CCN(CC)CC3)C4=CC=C(C(F)(F)F)C=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
ML311
Cat. No.:
HY-101778
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ML311

Cat. No.: HY-101778