Acanthaceae Extract

Ciliatoside A is a naturally bioactive compound that exhibits significant anti-inflammatory, antiviral, and neuroprotective activities. Ciliatoside A serves as a mitophagy inducer and NLRP3 inflammasome inhibitor, activating AMPK, SIRT1, and the PINK1/Parkin axis, and inhibiting pyroptosis and apoptosis. Ciliatoside A promotes autophagic flux, autophagosome-lysosome fusion, mTOR inhibition, and p62-dependent HBc degradation; reduces Aβ aggregation, plaque deposition, microglial/astrocyte activation, and bacterial load; and maintains neuronal integrity, mitochondrial membrane potential, and ATP production. Ciliatoside A is used in research on Alzheimer's disease, Klebsiella pneumoniae-induced pneumonia, hepatitis B virus infection, and inflammation.

Pronaphthalide A is a cytotoxic agent and an inhibitor of SFTSV glycoprotein Gn (domain B) (K_d = 0.74 mM). It blocks viral binding and internalization by binding to the conserved B domain of SFTSV Gn, thereby inhibiting SFTSV infection at the viral entry stage, and exhibits broad-spectrum antiviral activity against bunyaviruses. Pronaphthalide A can be used for research on gastric cancer, severe fever with thrombocytopenia syndrome, and HIV/AIDS.

Procumbenoside E is an arylnaphthalene lignan glycoside compound discovered from Justicia procumbens, and it possesses an arylnaphthalene lignan skeleton and a diphyllin structure.

Procumbenoside F is a lignan glycoside compound that can be isolated and extracted from Justicia procumbens L.. Procumbenoside F can be used in cancer research.

Procumbenoside A is a lignan glycoside discovered in Justicia procumbens. Procumbenoside A inhibits HIV-1 replication with an IC₅₀ of 4.95 μM. Procumbenoside A exerts cytotoxic effects on various cancer cells. Procumbenoside A induces Cu (II)-mediated strand breaks in supercoiled plasmid DNA, generating the relaxed circular DNA form, while no linear form is detected. Procumbenoside A is used in studies related to liver cancer, colon adenocarcinoma, and HIV-1 infection.

8,8'-Lignan-3,3',4,4',5,9,9'-heptol is a dibenzylbutane-type lignan that can be found in Justicia procumbens. It is useful for research related to lignan components and natural product chemistry.

Justalakonin is an arylnaphthalene glycoside that is found in Justicia purpurea. Justalakonin exhibits no significant inhibitory effects on lipid peroxidation, COX‑1, or the proliferation of various tumor cells, but possesses COX-2 inhibitory activity.

Sodium 14-deoxy-8,9-didehydro andrographolide-12(R)-sulfonate is a natural product that can be found in Andrographis paniculata.

Andrographis paniculata polysaccharide is a polysaccharide derived from Andrographis paniculata.

Justicia procumbens polysaccharide is a polysaccharide derived from Justicia procumbens.

Justicia adhatoda polysaccharide is a polysaccharide derived from Justicia adhatoda.

ent-Copalyl diphosphate (ent-CPP) is a terpenoid precursor and metabolite involved in plant biosynthetic pathways. ent-Copalyl diphosphate participates in metabolism of natural products including phytoalexins in rice and maize, and steviol glycoside in Stevia rebaudiana.

Clemontanoside-C is an oleanane-based triterpenoid saponin and antifungal agent found in the roots of Lepidagathis cuspidata. Clemontanoside-C acts against Aspergillus flavus, Rhizopus stolinifer, Penicillum nodatum, and Aspergillus fumigatus. Clemontanoside-C can be used for the research of fungal infections.

14-Deoxy-12-methoxyandrographolide, an ent-labdane-type diterpenoid found in the aerial parts of Andrographis paniculata, is a cell differentiation inducer. 14-Deoxy-12-methoxyandrographolide induces differentiation of myeloid leukemia cells via increased phagocytosis of polystyrene latex particles. 14-Deoxy-12-methoxyandrographolide can be used for the research of myeloid leukemia.

Justicidin F (Taiwanin E methyl ether) is a lignan found in Justicia procumbens Linn. var. leucantha Honda.

Naringenin-7-O-(6′′-E-p-coumaroyl-β-D-glucopyranoside) (Compound 6) is a natural product. Naringenin-7-O-(6′′-E-p-coumaroyl-β-D-glucopyranoside) can be isolated from the aerial parts of Blepharis ciliaris (L.) B.L. Burtt. Naringenin-7-O-(6′′-E-p-coumaroyl-β-D-glucopyranoside) does not exhibit antioxidant activity.

Magnolenin C is a glycoside with a ketolignan structure. Magnolenin C can be isolated from the aerial parts of Acanthus ebracteatus.

8-Methylandrograpanin (Compound I) is a diterpene found in the leaves of Andrographis paniculata (Burm.f.) Nees.

Andrographidine E is a COX-2 (IC₅₀ = 19 μM) and HDAC inhibitor, with high affinity for HDAC1 and HDAC3. Andrographidine E can specifically bind to macrophages and has potential immunotargeting properties. Andrographidine E can be used for studying inflammation.