Acanthaceae Extract

Andropanolide is a natural product that exerts cytotoxicity toward carcinoma cells and significantly inhibits the overproduction of nitric oxide (NO) in Lipopolysaccharides (HY-D1056) (LPS)-stimulated RAW264.7 macrophages.

Andropanoside is a natural product and possesses a protective activity against various liver disorders.

Osmanthuside B can be isolated from Pseuderanthemum carruthersii (Seem.) Guill. var. atropurpureum (Bull.) Fosb and has weak acetylcholinesterase inhibitory activity.

Andrographidine A is a natural product.

14-epi-andrographolide is a diterpene analog of Andrographolide (HY-N0191), which is an NF-κB inhibitor and antiviral agent.

Procumbide (compound 11) is a flavone glucoside. Procumbide can be isolated from Andrographis paniculata.

Andrographiside is a labdane diterpenoid glucoside that can be isolated from the leaves of Andrographis paniculata Nees. Andrographiside has antihepatotoxic and antioxidative effects. Andrographiside shows protective effects on mice with hepatotoxicity induced by carbon tetrachloride or tert-butylhydroperoxide (tBHP). Andrographiside is a novel biofilm inhibitor of Pseudomonas aeruginosa PAO1 by modulating quorum-sensing proteins.

Isoandrographolide is an orally active NLRP3 inflammasome inhibitor and AKT/GSK-3β/β-catenin pathway inhibitor. Isoandrographolide inhibits the expression of NLRP3, ASC, and caspase-1, and reduces the levels of phosphorylated AKT, phosphorylated GSK-3β, and β-catenin. Isoandrographolide alleviates inflammatory responses, reduces collagen deposition, suppresses epithelial-mesenchymal transition (EMT), induces differentiation of leukemia cells, inhibits the growth of leukemia cells, protects lung and kidney tissues, regulates cytokine levels, and also exhibits hepatoprotective effects. Isoandrographolide can be used in studies related to silicosis, murine myeloid leukemia, renal tubulointerstitial fibrosis, and non-alcoholic fatty liver disease.

Rhinacanthin C is an orally active naphthoquinone ester and P-gp inhibitor (IC₅₀ = 5.20 μM). Rhinacanthin C exerts effects in ameliorating hepatic steatosis, insulin resistance, and inflammation by inhibiting P-gp, BCRP, OATP1B1/1B3, and multiple CYP enzymes, downregulating lipid synthesis-related factors such as ACC and FAS, and upregulating AMPKα phosphorylation and SIRT1. Rhinacanthin C can be used in research on non-alcoholic fatty liver disease, diabetes, abnormal osteolysis, Alzheimer's disease, and inflammation.

Swertiajaponin 2''-O-rhamnoside (2''-O-Rhamnosylswertiajaponin) is a natural flavonoid.

Cilinaphthalide A is an arylnaphthalene lignan lactone that exhibits cytotoxic activity against bladder cancer and cervical cancer cell lines and possesses antibacterial activity against Escherichia coli. Cilinaphthalide A can be used for research on bladder cancer and cervical cancer.

Procumbenoside I is a naturally derived broad-spectrum antiviral agent targeting the SFTSV glycoprotein Gn. Procumbenoside I binds to the conserved B domain of SFTSV Gn, blocking the binding and internalization steps during viral entry. Procumbenoside I inhibits the entry of VSV, H5N1, and SARS-CoV-2 pseudoviral particles, while exhibiting antiviral activity against bunyaviruses such as LCMV and WELV. Procumbenoside I protects mice against lethal SFTSV challenge, reducing mortality and alleviating pathological damage. Procumbenoside I is useful for research related to viral infections.

Cilinaphthalide B is an integrin αIIbβ3 inhibitor and a phthalide derivative that inhibits platelet aggregation by binding to integrin αIIbβ3 and interfering with the conformational changes required for its activation, and it exhibits cytotoxicity against cancer cell lines. Cilinaphthalide B can be used in antiplatelet and anticancer-related research.

Procumbenoside B is an arylnaphthalene lignan glycoside found in Justicia procumbens.

Justicidinoside B is an arylnaphthalene lignan glycoside that can be found in the whole plant of Justicia procumbens, and it contains a β-D-glucopyranosyl sugar moiety.

Justiciosides F is a triterpenoid glycoside that can be isolated and extracted from Justicia betonica. Justiciosides F can be used in inflammation research.

Apigenin-6-C-arabinoside is a flavonoid C-glycoside found in the leaves of Adhatoda vasica. Apigenin-6-C-arabinoside is used in the study of natural product flavonoids and flavonoid glycosides.

Jusneesiin is a (1R)-angularly fused β-apolignan discovered from Justicia neesii.

Jusneesiinol is a lignan-class prostaglandin synthesis inhibitor and COX-1/COX-2 inhibitor that exerts central analgesic, peripheral analgesic, and antipyretic effects by inhibiting prostaglandin formation, antagonizing prostaglandin receptors, and inhibiting lipid peroxidation. Jusneesiinol can be used in research on pain and fever.