Piperaceae Extract

Methyl 2-O-β-D-glucopyranosylbenzoate (Methyl salicylate 2-O-β-D-glucopyranoside) (Compound 11) is a phenolic compound. Methyl 2-O-β-D-glucopyranosylbenzoate can be isolated from the leaves of Metapanax delavayi. Methyl 2-O-β-D-glucopyranosylbenzoate has anti-benign prostatic hyperplasia activities and significantly inhibits the proliferation of BPH-1 cells. β-Phenylethyl β-D-glucoside can be used for prostatitis research.

Isochavicine is an alkaloids that can be isolated from Piper retrofractum. Isochavicine inhibits the seedling growth of cress with I₅₀ values of 11 μM.

(E)-Methyl 3,4,5-trimethoxycinnamate is a bioactive natural phenylpropanoid. (E)-Methyl 3,4,5-trimethoxycinnamate suppresses inflammation in RAW264.7 macrophages and blocks macrophage-adipocyte interaction. (E)-Methyl 3,4,5-trimethoxycinnamate also has antiarrhythmic effect, leads to suppression of triggered activities in rabbit myocytes.

Tridecane is a short chain aliphatic hydrocarbon containing 13 carbon atoms. Tridecane is an volatile oil component isolated from essential oil of Piper aduncum L. Tridecane is a stress compound released by the brown marmorated stink bugs stress compound.

11-Methoxyyangonin is a natural kavalactone.

Aristolactam A II (Aristololactam A II) is a weak COX inhibitor with cytotoxic and anti-plasmodial activities. Aristolactam A II exhibits inhibitory activity against Chloroquine (HY-17589A)-sensitive strains, and exerts its inhibitory effect on Plasmodium falciparum growth by inducing cell membrane damage marked by LDH release. Aristolactam A II can be applied to the research of malaria-related mechanisms.

Futoquinol is a neolignan isolated from the dried aerial parts of Piper kadsura (Piperaceae). Futoquinol potently inhibits NO production in microglia cells. Futoquinol has anti-neuroinflammatory activities.

N-Isobutyl-2E,4E,12Z-octadecatrienamide is an unsaturated amide that can be found in the fruits of Piper retrofractum and stems and roots of Mallotus lianus Croiz.

(2E,4Z-Decadienoyl)piperidine is a herbicide found in the fruits of Piper longum L..

5-Hydroxy-3′,4′,7,8-tetramethoxyflavone is a flavone found in the whole plant of Peperomia sui. 5-Hydroxy-3′,4′,7,8-tetramethoxyflavone shows no activity against cancer cell lines in vitro.

Chingchengenamide A is a natural alkaloid.

(2E,4Z,8E)-Dehydropipernonaline is a natural product that can be found in Biba.

Schisphenin A is a natural product that can be found in Chang Sheng Qi.

Piperdardine is a natural alkaloid.

Valerianol is a sesquiterpene alcohol with anticancer, antibacterial, and antiviral activities. Valerianol selectively inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen (EBV-EA) activation (IC₅₀=300 μM). Valerianol inhibits tumor promoter-mediated EBV-EA activation and also inhibits pathogenic bacteria such as Staphylococcus aureus.

(2E)-Decenoylpiperidide (Compound 12) is a Sarmentine (HY-W099725) analogue. (2E)-Decenoylpiperidide shows phytotoxicity on barnyard grass.

Stigmalactam is an aristolactam-type alkaloid extracted from Orophea enterocarpa with anticancer effects. Stigmalactam induces apoptosis via the mitochondrial pathway, with the activation of caspase-3/9, and a decrease in mitochondrial membrane potential (MTP). Stigmalactam exhibits antioxidant activity by decreasing ROS production. Stigmalactam can be used for liver and breast cancer research.

Piperchabamide B is an amide alkaloid. Piperchabamide B can be isolated from the fruits of Piper longum. Piperchabamide B exhibits anticancer activity against acute promyelocytic leukemia, non-small cell lung cancer, and breast cancer.

Cedrenol is a sesquiterpene alcohol compound found in Juniperus virginiana.

Coumaperine is an amide alkaloid. Coumaperine can be extracted from white piper. Coumaperine inhibits NF-κB. Coumaperine derivatives exhibit anticancer activity against non-small cell lung cancer and Hodgkin's lymphoma. Coumaperine derivatives have antibacterial activity.