2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P991633
    TQC2938 98%
    TQC2938 is a humanized IgG2 monoclonal antibody inhibitor targeting Stimulation-2 (ST2). TQC2938 inhibits the ST2/IL-33 signaling pathway, reduces the level of downstream Th2 cytokines (such as IL-4, IL-5, and IL-13) and eosinophils as well as other inflammatory cells. TQC2938 can be used for inflammatory diseases like asthma research.
    TQC2938
  • HY-P991634
    IBI-325 98%
    IBI-325 is a humanized monoclonal antibody inhibitor targeting CD73. IBI-325 completely inhibits CD73 enzymatic activity without hook effect. IBI-325 reverses Adenosine monophosphate (HY-A0181)-mediated immune suppression and significantly inhibits T cell proliferation and cytokines (IL-2, IFN-γ and TNF-α) release. IBI-325 has potent antitumor activities in hPBMC-reconstituted mice model and hCD73 knock-in mice model. IBI-325 can be used for cancer immunotherapy research.
    IBI-325
  • HY-P991643
    MTRX1011A 98%
    MTRX1011A is a humanized IgG1 monoclonal antibody inhibitor targeting CD4. MTRX1011A can be used for rheumatoid arthritis (RA) research.
    MTRX1011A
  • HY-P991655
    AGS-009 98%
    AGS-009 is a humanized monoclonal neutralising antibody targeting IFN-α. AGS-009 significantly reduces activated lymphocytes, such as CD4+ and CD8+ T cells as well as B cells in SIV infection rhesus macaque models. AGS-009 can be used for autoimmune diseases like systemic lupus erythematosus (SLE) and HIV infections research.
    AGS-009
  • HY-P991659
    SCH708980 98%
    SCH708980 is a humanized monoclonal antibody inhibitor targeting IL-10. SCH708980 has anti-immunosuppressive activity. SCH708980 can be used for visceral leishmaniasis, sepsis-associated kidney injury (SAKI) and osteoporosis research.
    SCH708980
  • HY-P991666
    BMS-986090 98%
    BMS-986090 is a humanized monoclonal antibody antagonist targeting CD40. BMS-986090 is promising for research of autoimmune diseases such as systemic lupus erythematosus (SLE) and focal segmental glomerulosclerosis (FSGS).
    BMS-986090
  • HY-P991673
    Asedebart 3035422-95-5 98%
    Asedebart is a CHO-expressed human antibody that targets Adrenocorticotropic hormone (ACTH). Asedebart blocks the binding of ACTH to its receptor through antagonism. Asedebart has huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Asedebart can refer to Human IgG1 kappa, Isotype Control (HY-P99001). Asedebart can be used for inflammatory diseases such as psoriasis and ulcerative colitis research.
    Asedebart
  • HY-P991678
    Efpixileukin alfa 2996895-52-2 98%
    Efpixileukin alfa is a fusion protein that combines human IL-2 variant fused at the C-terminus to human immunoglobulin G1 (IgG1) Fc fragment. Efpixileukin alfa is an immunomodulator.
    Efpixileukin alfa
  • HY-P991680
    Elipunercept 3037408-21-9 98%
    Elipunercept is a fusion protein that combines human TNFRSF1B extracellular domain fragment (1-235) fused at the C-terminus to a human IgG1 Fc fragment. Elipunercept is an immunomodulator.
    Elipunercept
  • HY-P991696
    Lecomkafusp alfa 3037532-60-5 98%
    Lecomkafusp alfa is a fusion protein that combines human IL-2 fused via a protease cleavable peptide linker to a humanized single-domain VHH fragment anti-ALB (149-263). Lecomkafusp alfa is an immunomodulator and has antineoplastic activity.
    Lecomkafusp alfa
  • HY-P991717
    Sunakiment 2928519-36-0 98%
    Sunakiment is a humanized IgG1λ monoclonal antibody inhibitor targeting Thymic stromal lymphopoietin (TSLP). Sunakiment can be used for inflammatory and immune system disorders like ulcerative colitis, rheumatoid arthritis and allergy and cancers research.
    Sunakiment
  • HY-P991725
    Velvakiment 3036636-75-3 98%
    Velvakiment is a humanized VHH nanobody that targets IL-17A. Velvakiment can be used for autoimmune diseases such as multiple sclerosis and rheumatoid arthritis research.
    Velvakiment
  • HY-P991749
    Anti-Rat CD25 Antibody (OX-39) 98%
    Anti-Rat CD25 Antibody (OX-39) recognizes the 55 kDa low-affinity interleukin-2 receptor α chain (IL-2R α, CD25). Anti-Rat CD25 Antibody (OX-39) interacts with a single class of sites on the alpha chain of the rat R-IL2 with a high affinity (Kd of 0.8 nM) and competes with IL2 binding on this chain (Ki of 0.53 nM). Anti-Rat CD25 Antibody (OX-39) is a weak inhibitor in vitro on IL2-induced proliferation and in vivo on allograft rejection. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Rat CD25 Antibody (OX-39)
  • HY-P991751
    Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S) 98%
    Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S) reacts with the α3 domains of H-2Db of the MHC class I alloantigen expressed on nucleated cells from mice of the H-2Db haplotype. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).
    Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S)
  • HY-P991759
    Anti-Rat CD86 Antibody (OX-48) 98%
    Anti-Rat CD86 Antibody (OX-48) recognizes CD86, thereby blocking the binding of CD86 to CD28, and thus inhibiting T cell proliferation. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Rat CD86 Antibody (OX-48)
  • HY-P991760
    Anti-IL-10 Antibody (JES3-19F1) 98%
    Anti-IL-10 Antibody (JES3-19F1) reacts with human IL-10, and is a capture or coating antibody in ELISA applications. Anti-IL-10 Antibody (JES3-19F1) reduces bacterial load in Mycobacterium avium infected mice. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679).
    Anti-IL-10 Antibody (JES3-19F1)
  • HY-P991762
    Anti-Rat CD4 Antibody (W3/25) 98%
    Anti-Rat CD4 Antibody (W3/25) reacts with rat CD4. Anti-Rat CD4 Antibody (W3/25) inhibits CD4+ T cell activation by downregulating the CD4 molecule on the surface of lymphocytes. Anti-Rat CD4 Antibody (W3/25) inhibits antigen-induced T cell proliferation and IL2 production in MLR experiments. Anti-Rat CD4 Antibody (W3/25) can be used for the study of experimental allergic encephalomyelitis (EAE). Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-Rat CD4 Antibody (W3/25)
  • HY-P991765
    Anti-VISTA Antibody (GG8) 98%
    Anti-VISTA Antibody (GG8) reacts with human VISTA. Endogenous VISTA has inhibitory effects both as a ligand on APCs and as a receptor on T cells. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-VISTA Antibody (GG8)
  • HY-P991773
    Anti-Mouse CD11b Antibody (5C6) 98%
    Anti-Mouse CD11b Antibody (5C6) is a CD11b blocking antibody. Anti-Mouse CD11b Antibody (5C6) can be used for in vitro inhibition of myelomonocytic cell adhesion and in vivo inhibition of inflammatory cell recruitment. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CD11b Antibody (5C6)
  • HY-P991777
    Anti-Mouse CD86/B7-2 Antibody (2D10) 98%
    Anti-Mouse CD86/B7-2 Antibody (2D10) reacts with mouse CD86 (B7-2). Anti-Mouse CD86/B7-2 Antibody (2D10) reduces IL-4 production in T cells. Recommend Isotype Controls: Rat IgG2b kappa, Isotype Control (HY-P990682).
    Anti-Mouse CD86/B7-2 Antibody (2D10)
Cat. No. Product Name / Synonyms Application Reactivity