Inflammation/Immunology

Isoformononetin-d3 is the deuterium labeled Isoformononetin (HY-N7501). Isoformononetin is an analog of Daidzein (HY-N0019) and has immunoprotective effects. Isoformononetin inhibits the differentiation of Th17 and B-cells lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions.

Anti-inflammatory agent 10 (compound 30) is a tilomisole-based benzimidazothiazole derivative. Anti-inflammatory agent 10 expresses activity on COX-2 enzyme more than COX-1. Anti-inflammatory agent 10 is orally active.

(S)-Dexfadrostat ((S)-Fadrozole) is an aromatase inhibitor with an IC₅₀ of 4.6 nM in human placental microsomes in vitro. (S)-Dexfadrostat can be used in the study of estrogen-dependent breast cancer, gynecomastia, and systemic lupus erythematosus.

3-Hydroxyphenylacetic acid-d₆ is the deuterium labeled 3-Hydroxyphenylacetic acid (HY-W001083). 3-Hydroxyphenylacetic acid is an orally active flavonoid metabolite produced by intestinal flora, with blood pressure-lowering activity. 3-Hydroxyphenylacetic acid can also inhibit ferroptosis by upregulating the expression of GPX4, thereby improving spermatogenic dysfunction in aged mice. In addition, abnormal levels of 3-Hydroxyphenylacetic acid are closely related to certain diseases, such as autism spectrum disorders.

20(22Z)-Ginsenoside Rh4 is a rare ginsenoside with antitumor, anti-inflammation, and anti-diabetic activities.20(22Z)-Ginsenoside Rh4 can be found in Panax ginseng.

Benzoylgomisin P is an anti-inflammatory agent.

NSC309401 is an inhibitor of E. coli DHFR (IC₅₀: 189 nM, K_D: 14.57 nM).

AC10142A is a selective Adenylyl Cyclase Type 1 inhibitor with IC₅₀ of 0.26 μM. AC10142A can be used to study pain models.

Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a mouse-derived IgG2a κ antibody inhibitor that targets mouse 4-1BBL/CD137L. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) is a chimeric version of the original TKS-1 antibody (HY-P990304). The variable domain sequences are identical to the original TKS-1 but the constant region sequences have been switched from rat IgG2a to mouse IgG2a. Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) reacts with mouse 4-1BB ligand (4-1BBL). Anti-Mouse 4-1BBL/CD137L Antibody (TKS-1-Mouse IgG2a) can be used for the researches of cancer, infection, inflammation and immunology.

Anti-IL-17RB Antibody is a monoclonal antibody targeting IL-17RB. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-IL-17RB Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC₅₀=1.4 nM). αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis).

Tripelennamine citrate is a histamine H1-receptor antagonist. Tripelennamine citrate effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine citrate does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine citrate exhibits local and central analgesic activity. Tripelennamine citrate can be used in studies related to emphysema, urticaria and acute laminitis.

Prednisone 21-aldehyde/22-hydroxy Prednisone is a mixture of Prednisone 21-aldehyde (HY-167546) and 22-hydroxy prednisone.

Spaglumic acid (N-Acetylaspartylglutamic acid) trisodium is a neuropeptide that exists in millimolar concentrations in the brain and possesses anti-allergic activity.

α-Glucosidase-IN-121 is a yeast α-glucosidase inhibitor with an IC₅₀ of 3.8 μM and a K_i of 12.9 μM. α-Glucosidase-IN-121 binds to the active site of the enzyme, competes with substrate binding, and forms stable interactions with Phe137, Ser308, Pro309, Arg312 and Glu350 via hydrogen bonding, π-π stacking and hydrophobic interactions. α-Glucosidase-IN-121 can be used in the research of diabetes.

The Anti-MRC2/CD280 Antibody is a humanized antibody expressed in CHO cells, targeting MRC2/CD280. The Anti-MRC2/CD280 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.42 kDa. The isotype control for the Anti-MRC2/CD280 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Cbl-b-IN-19 (Compound 49) is an inhibitor for casitas B-lineage lymphoma b(Cbl-b), that inhibits Cbl-b phosphorylation with an IC₅₀ < 100 nM.

Imperata cylindrica root extract (Cogon grass rhizome extract) is an extract of Imperata cylindrica Linn. Beauv., which is widely used in research on urinary stones, diabetes, heart disease, gout, cough, inflammation, anemia, etc.

CMKLR1 antagonist 2 (compound 16) is a full and competitive chemerin/chemokine-like receptor 1 (CMKLR1) antagonist with an IC₅₀ of 37 μM. CMKLR1 antagonist 2 can be used for study of inflammation.

Dendrocandin E is a bibenzyl derivative and antioxidant found in the stems of Dendrobium candidum, with an IC₅₀ of 15.6 μM for DPPH radical scavenging. Dendrocandin E scavenges DPPH free radicals.