Neurological Disease

D-(-)-Quinic acid (Standard) is the analytical standard of D-(-)-Quinic acid. This product is intended for research and analytical applications. D-(-)-Quinic acid scavenges hydrogen peroxide (IC₅₀=87.11 μg/mL) and exhibits antioxidant activity. D-(-)-Quinic acid is the inhibitor for MAO and α-Glucosidase (IC₅₀ =93.75 μg/mL). D-(-)-Quinic acid is orally active.

O6-Benzylguanine sodium is an orally active, blood-brain barrier-penetrant inhibitor of O⁶-methylguanine-DNA methyltransferase (MGMT/AGT). O6-Benzylguanine sodium modulates p53 and its downstream p21 and cyclins to induce cell cycle arrest and apoptosis, and on the other hand activates mTORC1/MAPK and other signaling pathways to induce cellular senescence by inhibiting intracellular MGMT. O6-Benzylguanine sodium is used in research related to various tumors, cellular senescence, and vascular smooth muscle dysfunction.

(R,R,S)-GAT107 is a fully agonistic positive modulator of α7 nicotinic receptors with significant biological activity. Its activity is entirely present in its (+)-isomer 1b, while (-)-isomer 1a does not affect its activity when used together. Studies have shown that (R,R,S)-GAT107 is the most potent ago-PAM for α7 nicotinic receptors currently known and has the potential for further in vivo evaluation.

RX 801077 (hydrochloride) (Standard) is the analytical standard of RX 801077 (hydrochloride) (HY-100904). This product is intended for research and analytical applications. RX 801077 hydrochloride (2 BFI) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 hydrochlorideshows anti-inflammation and neuroprotection. RX 801077 hydrochloride has the potential for the research of traumatic brain injury (TBI).

PiPT is a Tryptamine (HY-B2132) compound.

GSK-3β inhibitor 26 (Compound D14) is a GSK-3β inhibitor with an IC₅₀ of 18.23 μM. GSK-3β inhibitor 26 can be used in the research of cancer, inflammation and neurodegenerative diseases.

(S)-Salsolinol (Standard) is the analytical standard of (S)-Salsolinol. This product is intended for research and analytical applications. (S)-Salsolinol ((-)-Salsolinol) is a dopamine-derived endogenous metabolite.

Desmethylmoramide is structurally similar to known opioids. Desmethylmoramide has analgesic activity in rodents.

GRIN2A modulator-1 is a GRIN2A modulator.

GET73 (Standard) is the analytical standard of GET73 (HY-108034). This product is intended for research and analytical applications. GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus.

(R)-Oxybutynin-d₁₀ (Aroxybutynin-d₁₀) is deuterium labeled (R)-Oxybutynin. (R)-Oxybutynin (Aroxybutynin) is the racemic isomer of Oxybutynin and an orally active muscarinic receptor antagonist. (R)-Oxybutynin has antispasmodic, antimuscarinic, and anticholinergic activities and competitively antagonizes carbachol-induced contractions. (R)-Oxybutynin can be used to study urinary incontinence caused by neurogenic bladder dysfunction.

(RS)-APICA (Standard) is the analytical standard of (RS)-APICA (HY-101375). This product is intended for research and analytical applications. (RS)-APICA is a selective group II metabotropic glutamate receptor (mGluR II) antagonist. (RS)-APICA shows potential neuroprotective effect.

NS1652 (Standard) is the analytical standard of NS1652 (HY-100244). This product is intended for research and analytical applications. NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.

Phlorizin (Floridzin) (Standard) is the analytical standard of Phlorizin. This product is intended for research and analytical applications. Phlorizin is an orally active non-selective sodium-glucose cotransporter (SGLT) inhibitor, with an IC₅₀ of 0.04 μM and a K_i of 39 nM against hSGLT2, and an IC₅₀ of 0.17 μM and a K_i of 0.31 μM against hSGLT1. Phlorizin promotes GLUT4 translocation, inhibits gluconeogenesis and promotes glycogen synthesis by activating the PI3K/Akt/mTOR pathway. Phlorizin reduces DNA damage and apoptosis (apoptosis) by inhibiting the NF-κB inflammatory pathway. Phlorizin induces apoptosis via activating the Caspase pathway by antagonizing the JAK/STAT3 and PCK pathways. Phlorizin also exhibits antibacterial, anti-inflammatory and neuroprotective activities.

Budipine hydrochloride is an anti-parkinson agent. Budipine hydrochloride also is a substrate of P-glycoprotein (P-gp), is mediated the uptake into the brain by P-gp. Budipine hydrochloride also is N-methyl-d-aspartate (NMDA) antagonist, and has indirect dopaminergic effects through an improved dopamine release, the inhibition of monoamine oxidase type B (MAO-B). Budipine hydrochloride can be used for the research of CNS disorders include Parkinson disease.

Linalyl acetate (Standard) is the analytical standard of Linalyl acetate. This product is intended for research and analytical applications. Linalyl acetate is the principal components of many plant essential oils. Linalyl acetate exhibits anti-anxiety, anti-inflammatory, anti-diabetic, anti-stress, and cardiovascular-regulatory effects. Linalyl acetate is orally active.

Piperidolate (Standard) is the analytical standard of Piperidolate. This product is intended for research and analytical applications. Piperidolate is a cholinergic antagonist. Piperidolate prevents ventricular fibrillation during hypothermic cardiac manipulations to support cardiac procedures post-preoperative defibrillation. Piperidolate causes dose-dependent cardiac depression. Piperidolate can be used for the research of ventricular fibrillation.

4,7,10,13,16,19-Docosahexaenoyl chloride is an ester derivative formed by Iloperidone (HY-17410) metabolite P-88-8991 and polyunsaturated fatty acid (linoleic acid derivative), which acts as a prodrug of P-88-8991. 4,7,10,13,16,19-Docosahexaenoyl chloride can be used for the research of mental disorders (schizophrenia, bipolar disorder).

Q-VD-OPh (Standard) is the analytical standard of Q-VD-OPh (HY-12305). This product is intended for research and analytical applications. Q-VD-OPh is an irreversible pan-caspase inhibitor with potent antiapoptotic properties; inhibits caspase 7 with an IC₅₀ of 48 nM and 25-400 nM for other caspases including caspase 1, 3, 8, 9, 10, and 12. Q-VD-OPh can inhibits HIV infection. Q-VD-OPh is able to cross the blood-brain barrier.

Veralipride (Standard) is the analytical standard of Veralipride. This product is intended for research and analytical applications. Veralipride is a D2 receptor antagonist. It is an alternative antidopaminergic treatment for menopausal symptoms.