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  3. Tafenoquine

Tafenoquine (Synonyms: WR 238605)

Cat. No.: HY-111529
Handling Instructions

Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent.

For research use only. We do not sell to patients.

Tafenoquine Chemical Structure

Tafenoquine Chemical Structure

CAS No. : 106635-80-7

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Description

Tafenoquine (WR 238605) is an 8-aminoquinoline. Tafenoquine is an anti-malarial prophylactic agent[1].

IC50 & Target

Anti-malarial[1]

In Vivo

Tafenoquine exhibits no anti-malarial activity in CYP 2D knock-out mice when dosed at their ED100 values (3 mg/kg) established in WT mice. Tafenoquine anti-malarial activity is partially restored in humanized/CYP 2D6 knock-in mice when tested at two times its ED100 (6 mg/kg)[1].

Clinical Trial
Molecular Weight

463.49

Formula

C₂₄H₂₈F₃N₃O₃

CAS No.

106635-80-7

SMILES

CC1=CC(OC)=NC2=C1C(OC3=CC=CC(C(F)(F)F)=C3)=C(OC)C=C2NC(CCCN)C

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tafenoquine
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