ADC Payloads
ADC Cytotoxins
ADC payloads are cytotoxic agents that induce target cell death in Antibody Drug Conjugates (ADCs). An ADC is a targeted agent composed with a monoclonal antibody, a linker and a payload. The payload is the most important component as it determines the potency to kill cancer cells of an ADC.
There are many payloads which are currently being used such as Calicheamicins, Duocarmycins, Pyrrolobenzodiazepines (PBDs), Camptothecins, Daunorubicins/Doxorubicins, Auristatins and Maytansinoids. They can be divided in two classes based on their mechanism of action, DNA damaging agents and tubulin inhibitors. Among them Calicheamicins, Duocarmycins and PBDs are DNA minor grove binders, Camptothecins and Daunorubicins/Doxorubicins are topoisomerase inhibitors, which are DNA damaging agents. Auristatins and Maytansinoids are tubulin inhibitors.
ADC Payloads Isoform Specific Products
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ADC Payloads
(218)
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Auristatin
(15)
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Calicheamicins
(1)
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Camptothecins
(42)
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Daunorubicins/
Doxorubicins (11)View all products
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Duocarmycins
(18)
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Maytansinoids
(10)
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Pyrrolobenzodiazepines
(8)
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Traditional Cytotoxic Agents
(24)
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All Product Categories
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ADC Payloads Related Products (371)
Related Products (371)
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Antibodies (2)
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Related Compound Screening Libraries (1)
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ADC Payloads Isoform Comparison
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PROTAC BRD4 Degrader-5-CO-PEG3-N3
0 ImagesPROTAC BRD4 Degrader-5-CO-PEG3-N3 is a PROTAC-linker Conjugate for PAC, comprises the BRD4 degrader (MZ 1 (HY-107425) analog) and PEG-based linker. PROTAC BRD4 Degrader-5-CO-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTAC BRD4 Degrader-5-CO-PEG3-N3 can be used for the research of HER2-positive breast cancer.
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Maytansinol
0 ImagesSynonyms: Ansamitocin P-0
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Hemiasterlin
0 ImagesSynonyms: (-)-Hemiasterlin; Milnamide BHemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs).
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N-Acetyl-Calicheamicin
0 ImagesSynonyms: N-Acetyl-Calicheamicin γ; N-Acetyl-γ-calicheamicinN-Acetyl-Calicheamicin (N-Acetyl-Calicheamicin γ), an enediyne anti-tumor antibiotic, is an ADC cytotoxin. N-Acetyl-Calicheamicin can induce DNA damage, and can be used in the synthesis of ADC.
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(R)-Benzyl 2-cyclopropyl-2-hydroxyacetate
0 Images(R)-Benzyl 2-cyclopropyl-2-hydroxyacetate can be used in the synthesis of pyrrolidines, a relevant molecule for ADC applications.
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N-Me-L-Ala-maytansinol
0 ImagesN-Me-L-Ala-maytansinol is a hydrophobic, cell permeable payload used for making antibody-drug conjugate (ADC).
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Fmoc-MMAE
0 ImagesFmoc-MMAE is a protective group-conjugated monomethyl auristatin E (MMAE), which is a potent tubulin inhibitor. Fmoc-MMAE can be used in the synthesis of ADC.
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Exatecan Intermediate 5
0 ImagesExatecan Intermediate 5 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 5 can be used to synthesize Antibody-Drug Conjugates (ADCs).
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Dexamethasone (GMP)
0 ImagesDexamethasone (Hexadecadrol) (GMP) is Dexamethasone (HY-14648) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Dexamethasone is an agonist of glucocorticoid receptor.
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Dolastatin 10
0 ImagesSynonyms: DLS 10; NSC 376128Dolastatin 10 (DLS 10) is a potent antimitotic peptide that inhibits tubulin polymerization.
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E104
0 ImagesE104 (compound 1) is a potent and selective TLR7 agonist. E104 can be delivered by antibody-drug conjugate (ADC) technology to elicit potent anticancer activity. E104 induces the activation of mouse macrophages and hPBMCs.
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Glucocorticoid receptor agonist-2
0 ImagesCat. No.: HY-148435CAS No.: 2166378-92-1Glucocorticoid receptor agonist-2 (compound 21) is an glucocorticoid receptor agonist with an IC50 value of 6.6 nM. Glucocorticoid receptor agonist-2 can be used to synthesize anti-inflammatory ADC molecules. Glucocorticoid receptor agonist-2 is an active reference of ABBV-3373.
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Tubulysin
0 ImagesTubulysin is a microtubule destabilizer that binds to the β-tubulin peptide site adjacent to the vinca alkaloid binding site and inhibits tubulin polymerization. Tubulysin induces apoptosis and exhibits antiproliferative activity against a variety of human cancer cells, including multidrug-resistant strains. Tubulysin can be conjugated to antibodies via a disulfide-containing quaternary ammonium linker for ADC synthesis. Tubulysin is applicable to tumor-related research.
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Duostatin 5
0 ImagesDuostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
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Exatecan Intermediate 1-d5
0 ImagesExatecan Intermediate 1-d5 is the deuterium labeled Exatecan Intermediate 1.
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PROTAC BTK Degrader-16
0 ImagesPROTAC BTK Degrader-16 is a BTK PROTAC degrader with a DC50 of 0.0006 nM in TMD8 cells. PROTAC BTK Degrader-16 recruits E3 ligase CRBN to tag BTK for degradation, leading to loss of BTK signaling. PROTAC BTK Degrader-16 induces degradation of BTK, leading to inhibition of cell growth in ABC-DLBCL cells. PROTAC BTK Degrader-16 can be used for the research of activated b-cell-like diffuse large b-cell lymphoma (ABC-DLBCL).
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Rezetecan
0 ImagesCat. No.: HY-147408Purity: 98.90%Synonyms: SHR9265Rezetecan is a topoisomerase I inhibitor with cytotoxicity. Rezetecan can serve as an antibody-drug conjugate payload (ADC Payloads), for example, it participates in the synthesis of Tizetatug rezetecan (HY-177711). Rezetecan is applicable to research related to various cancers such as breast cancer and gastric cancer.
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MMAD
0 ImagesSynonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10MMAD is a potent tubulin inhibitor, is a toxin payload in antibody agent conjugates (ADCs).
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MMAF sodium
0 ImagesSynonyms: Monomethylauristatin F sodiumMMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A.
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7-MAD-MDCPT hydrochloride
0 ImagesCat. No.: HY-132162ACAS No.: 2740593-09-17-MAD-MDCPT hydrochloride, a Camptothecin analog, is a toxin payload in antibody drug conjugates (ADCs).
