1. Signaling Pathways
  2. Anti-infection
  3. Arenavirus

Arenavirus

Arenavirus genome includes two ambisense RNA segments that encode only four viral proteins: the envelope glycoprotein precursor, nucle-ocapsid protein, matrix zinc-binding (Z) protein and the large (L) RNA-dependent RNA polymerase (RdRp). The L protein is a multi-domain machinery with both transcription and replication activities. Similar to other segmented negative-sense RNA viruses (sNSVs), the replication of arenavirus genome is de novo initiated and involves a complementary RNA (cRNA) intermediate, whereas the transcription process presumably requires a host mRNA-derived primer captured by the viral polymerase through cap snatching.

Arenaviruses can cause severe haemorrhagic fever and neurological diseases in humans and other animals, exemplified by Lassa mammarenavirus, Machupo mammarenavirus and lymphocytic choriomeningitis virus, posing great threats to public health. These viruses encode a large multi-domain RNA-dependent RNA polymerase for transcription and replication of the viral genome. Viral polymerases are one of the leading antiviral therapeutic targets.

Arenavirus Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-101441
    ST-193
    Inhibitor 99.86%
    ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
  • HY-114698
    Retro-2 cycl
    Inhibitor 98.11%
    Retro-2 cycl (RN 1-001) is a dihydroquinazolinone (DHQZ) inhibitor of retrograde trafficking. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus with IC50s of 54 μM and 160 μM, respectively. Antiviral agent.
  • HY-112762
    LHF-535
    Inhibitor 98.82%
    LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
  • HY-101441A
    ST-193 hydrochloride
    Inhibitor 98.54%
    ST-193 hydrochloride is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively.
  • HY-112762A
    (E)-LHF-535
    Inhibitor 99.71%
    (E)-LHF-535 is the E-isomer of LHF-535. LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
  • HY-N1970
    5,7-Dihydroxychromone
    Activator 99.94%
    5,7-Dihydroxychromone, the extract of Cudrania tricuspidata, activates Nrf2/ARE signal and exerts neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced oxidative stress and apoptosis. 5,7-Dihydroxychromone inhibits the expression of activated caspase-3 and caspase-9 and cleaved PARP in 6-OHDA-induced SH-SY5Y cells.
  • HY-P0323
    GP(33-41)
    Inhibitor
    GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM.
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