Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
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Beta-lactamase Related Products (261)
Related Products (261)
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Beta-lactamase Isoform Comparison
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β-Lactamase-IN-6
0 ImagesCat. No.: HY-115872CAS No.: 2326468-84-0β-Lactamase-IN-6 is a β-Lactamase inhibitor that shows high antibacetrial activity.
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GT-055 free base
0 ImagesCat. No.: HY-187939CAS No.: 2092930-66-8Synonyms: LCB18-055 free baseGT-055 free base (LCB18-055 free base) is a broad-spectrum β-lactamase inhibitor and penicillin-binding protein 2 (PBP2) inhibitor. GT-055 free base inactivates β-lactamase, protects GT-1 from hydrolysis, and binds tightly to PBP2, thereby inhibiting cell wall biosynthesis. GT-055 free base can be used for research on bacterial infections.
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ANT2681
0 ImagesCat. No.: HY-176519CAS No.: 2270184-16-0ANT2681 is a potent NDM inhibitor with a Ki value of 0.04 μM against NDM-1. ANT2681 also inhibits other MBLs, such as VIM-1 and IMP-1 with Ki values of 0.63 μM and 3.81 μM, respectively. ANT2681 can be used in combination with Meropenem (HY-13678) to inhibit infections caused by NDM-producing Enterobacteriaceae.
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Avibactam-13C5,15N sodium
0 ImagesCat. No.: HY-14879S7Synonyms: NXL-104-13C5,15N sodium
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BLI-489 free base
0 ImagesCat. No.: HY-108062BCAS No.: 635322-76-8BLI-489 free base is a Beta-lactamase inhibitor. BLI-489 free base is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 free base blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn2+ through an oxygen atom in metallo-Beta-lactamase. BLI-489 free base can be used for research on bacterial infections.
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β-Lactamase-IN-10
0 ImagesCat. No.: HY-178975β-Lactamase-IN-10 (Compound CB1) is a dual-metal β-lactamase (MLB) and serine β-lactamase (SLB) inhibitor. β-Lactamase-IN-10 exhibits antibacterial (antibacterial) activity against various drug-resistant bacteria. β-Lactamase-IN-10 can be used in the research of Gram-negative superbug infections.
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YL6113
0 ImagesCat. No.: HY-178976YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection.
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Metallo-β-lactamase-IN-9
0 ImagesCat. No.: HY-152105CAS No.: 1802363-75-2Metallo-β-lactamase-IN-9 (Compound 23) is a pan metallo-beta-lactamase (MBL) inhibitor with IC50s of 35, 269 and 369 nM against NDM-1, VIM-1 and IMP-1, respectively.
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NDM-1-IN-12
0 ImagesCat. No.: HY-179709NDM-1-IN-12 (Compound 10c) is an inhibitor of NDM-1 metallo-β-lactamase, with an IC50 value of 9 nM. NDM-1-IN-12 effectively reverses bacterial resistance to β-lactam antibiotics and shows an additive effect when used in combination with antibiotics and SBL inhibitors. NDM-1-IN-12 can be used in the research of anti-multi-drug resistant bacteria.
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Nacubactam (Standard)
0 ImagesCat. No.: HY-109008RCAS No.: 1452458-86-4Synonyms: OP0595 free acid (Standard)Nacubactam (Standard) is the analytical standard of Nacubactam (HY-109008). This product is intended for research and analytical applications. Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and C β-lactamases. Nacubactam acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. Nacubactam potentiates the antimicrobial activities of Piperacillin (HY-B1923), Cefepime (HY-B0692), and Meropenem (HY-13678) against CTX-M-15-positive Escherichia coli and KPC-positive Klebsiella pneumoniae.
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Cefditoren pivoxil-d3
0 ImagesCat. No.: HY-17452ASSynonyms: Cefditoren pivoxyl-d3; Cefditoren pivaloyloxymethyl ester-d3; ME 1207-d3Cefditoren Pivoxil-d3 (Cefditoren pivoxyl-d3) is deuterium labeled Cefditoren Pivoxil. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
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Cefotaxime sodium (Standard)
0 ImagesCat. No.: HY-A0088RCAS No.: 64485-93-4Synonyms: Cefotaxim sodium (Standard); HR-756 sodium (Standard)Cefotaxime (sodium) (Standard) is the analytical standard of Cefotaxime (sodium). This product is intended for research and analytical applications. Cefotaxime (Cefotaxim) sodium, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
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ML121
0 ImagesCat. No.: HY-128049CAS No.: 1212185-26-6ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli.
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Aspergillomarasmine A
0 ImagesAspergillomarasmine A is a fungal secondary metabolite derived from natural amino acids, with inhibitory activity against metallo-β-lactamases. Aspergillomarasmine A selectively inhibits the metallo-β-lactamases NDM-1 and VIM-2, but shows weak inhibitory activity against IMP-7. Aspergillomarasmine A exhibits metal ion selectivity, which enables it to capture spontaneously dissociated Zn2+ from NDM-1, inducing the monozincation and inactivation of the enzyme; the inactivated metallo-β-lactamase undergoes protein degradation in the bacterial periplasm, thereby restoring the bacteriostatic efficacy of carbapenem antibiotics. Aspergillomarasmine A can be used in studies related to bacterial infections.
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Fmoc-FFC
0 ImagesCat. No.: HY-189634Fmoc-FFC is a competitive MBL (NDM-1, VIM-2, and IMP-1) inhibitor with Ki values of 2.3, 6.0, and 7.1 μM, respectively. Fmoc-FFC alone has no antibacterial activity, but acts synergistically with Meropenem (HY-13678) to restore antibacterial activity against MBL/NDM-1-producing E. coli. Fmoc-FFC supports cell-cell adhesion and can serve as a scaffold for cell culture growth. Fmoc-FFC can be used in research on systemic infections caused by NDM-1-producing E. coli.
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Cefonicid sodium (Standard)
0 ImagesCat. No.: HY-B1300RCAS No.: 61270-78-8Cefonicid sodium (Standard) is the analytical standard of Cefonicid sodium (HY-B1300). This product is intended for research and analytical applications. Cefonicid sodium is a long-acting cephalosporin antibiotic. Cefonicid sodium also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid sodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid sodium can be used for research on infections.
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Meropenem-vaborbactam (Standard)
0 ImagesCat. No.: HY-111521RCAS No.: 2031124-72-6Synonyms: Carbavance (Standard)Meropenem-vaborbactam (Standard) is the analytical standard of Meropenem-vaborbactam (HY-111521). This product is intended for research and analytical applications. Meropenem-vaborbactam (Carbavance) is a Carbapenem Antibiotic and Boronic acid-based beta-lactamase inhibitor, is a fixed-dose combination product with potent in vitro activity against Enterobacteriaceae that are Klebsiella pneumoniae carbapenemase producers. Meropenem-vaborbactam exhibits activity against Pseudomonas aeruginosa isolates , with an MIC50 of 0.5 μg/mL and an MIC90 of 8 μg/mL.
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WCK-4234 free base
0 ImagesCat. No.: HY-125604ACAS No.: 1706523-58-1WCK-4234 free base is a diazabicyclooctane β-lactamase inhibitor and susceptibility restorer. WCK-4234 free base lacks direct antibacterial activity. WCK-4234 free base inhibits class A, C, D β-lactamases and extended-spectrum β-lactamases to potentiate Imipenem (HY-B1369A) and Meropenem (HY-13678) activity against Gram-negative pathogens. WCK-4234 free base can be used for the research of gram-negative bacterial infections and β-lactamase-mediated carbapenem-resistant bacterial infections.
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Cephalothin (Standard)
0 ImagesSynonyms: Cephalotin (Standard)Cephalothin (Cephalotin) (Standard) is the analytical standard of Cephalothin (HY-B1275A). This product is intended for research and analytical applications. Cephalothin is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an Ki of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies.
