Beta-lactamase
β-lactamase
Beta-lactamase (β-lactamase) is associated with multiple drug resistance in bacteria. It is able to hydrolyze or degrade the β-lactam ring, which is the core structure and active region of many antibiotic molecules such as penicillin, cephalosporins and kanamycin. Bacteria produce Lactamase in response to beta-lactam antibiotics. Using Lactamase inhibitors inhibits the activity of Lactamase so that it cannot destroy the beta-lactam ring of the antibiotic. Lactamase inhibitors are often used with beta-lactam antibiotics to enhance their effectiveness.
Beta-lactamase Isoform Specific Products
All Product Categories
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Beta-lactamase Related Products (259)
Related Products (259)
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Beta-lactamase Isoform Comparison
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Avibactam free acid (Standard)
0 ImagesCat. No.: HY-14879RCAS No.: 1192500-31-4Synonyms: NXL-104 free acid (Standard)Avibactam (free acid) (Standard) is the analytical standard of Avibactam (free acid). This product is intended for research and analytical applications. Avibactam (NXL-104) free acid is a covalent and reversible non-β-lactam β-lactamase inhibitor which inhibits β-lactamase TEM-1 and CTX-M-15 with IC50s of 8 nM and 5 nM, respectively[1].
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Izumenolide
0 ImagesCat. No.: HY-N15020CAS No.: 76265-39-9Izumenolide is found in the strain of Micromonospora chalcea subsp. izumensis. Izumenolide inhibited some β-lactamases, and the IC50 concentration of TEM-2 β-lactamase was 0.01 μg/mL.
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NDM-1 inhibitor-8
0 ImagesCat. No.: HY-168861NDM-1 inhibitor-8 (Compound 18b) is the covalent inhibitor for new delhi metallo-β-lactamase-1 (NDM-1) with an IC50 of 7.03 μM. NDM-1 inhibitor-8 inhibits the drug resistant strains, exhibits synergistic antibacterial effect with the use of Meropenem (HY-13678). NDM-1 inhibitor-8 exhibits anti-infectious activity in mouse models.
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BAL-0019764
0 ImagesCat. No.: HY-108080CAS No.: 404824-79-9
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β-Lactamase-IN-11
0 ImagesCat. No.: HY-180116β-Lactamase-IN-11 is a β-Lactamase Inhibitor with an IC50 of 30.37 μM. β-Lactamase-IN-11 exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, demonstrating potential for combating various drug-resistant bacteria. β-Lactamase-IN-11 can be used for studying infections caused by enzyme-producing drug-resistant bacteria.
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Carpetimycin B
0 ImagesCat. No.: HY-N13978CAS No.: 76094-36-5Carpetimycin B has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin B has a strong inhibitory effect on β-lactamase.
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Cefditoren Pivoxil (Standard)
0 ImagesSynonyms: Cefditoren pivoxyl (Standard); Cefditoren pivaloyloxymethyl ester (Standard); ME 1207 (Standard)Cefditoren Pivoxil (Standard) is the analytical standard of Cefditoren Pivoxil. This product is intended for research and analytical applications. Cefditoren Pivoxil (ME 1207) is a broad-spectrum, third-generation, oral cephalosporin antibacterial with enhanced stability against many common β lactamases. Cefditoren Pivoxil has activity against Gram-negative organisms and Gram-positive organisms. Cefditoren Pivoxil can be used in the research of infection diseases such as acute exacerbations of chronic bronchitis, community-acquired pneumonia (CAP), streptococcal pharyngitis/tonsillitis, or uncomplicated skin and skin structure infections.
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Dotriacolide
0 ImagesCat. No.: HY-N14735CAS No.: 80994-06-5Dotriacolide is a β-actamase inhibitor. Dotriacolide has significant inhibitory activities against both penicillinase and cephalosporinase with ID50 values of 0.61 μg/mL and 0.15 μg/mL, respectively. Dotriacolide is promising for research of infectious diseases.
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2'-Hydroxybiphenyl-3-carboxylic acid
0 Images2'-Hydroxybiphenyl-3-carboxylic acid is a β-lactamase oxa-48 inhibitor (IC50 = 50 µM; Kd = 1750 µM) .
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WCK-5153
0 ImagesCat. No.: HY-120366CAS No.: 1452460-79-5WCK-5153 is a Penicillin-Binding Protein 2 (PBP2) inhibitor with an IC50 of 0.14 μg/ml (for P. aeruginosa PBP2) and acts as a β-lactam enhancer against Pseudomonas aeruginosa. WCK-5153 can be used in studies of multidrug-resistant (MDR) pathogens.
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D-Captopril
0 ImagesCat. No.: HY-B0368BCAS No.: 119238-52-7D-Captopril is a NDM-1 inhibitor and a competitive BlaB inhibitor, with an IC50 value of 21.8 µM against NDM-1 and a Ki of 70-100 µM against BlaB. D-Captopril synergistically reduces the minimum inhibitory concentration of Meropenem (HY-13678) against NDM-1-expressing bacteria. D-Captopril binds to BcII via its thiolate sulfur atom and carboxylate group, altering metal ion occupancy and modulating Cd2+ binding affinity. D-Captopril can be used in the research of neonatal meningitis, sepsis and bacterial infections.
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Olivanic acid
0 ImagesCat. No.: HY-N14919CAS No.: 64761-66-6Olivanic acid is a β -lactam antibiotic. Olivanic acid has the effect of anti -Gram-positive bacteria and anti-Gram-negative bacteria. Olivanic acid inhibits β-lactamase.
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Cefonicid monosodium
0 ImagesCat. No.: HY-B1300BCAS No.: 71420-79-6Cefonicid monosodium is a long-acting cephalosporin antibiotic. Cefonicid monosodium also acts as a noncompetitive class I β-lactamase inhibitor with a Ki value of 0.8 μM. Cefonicid monosodium exhibits broad-spectrum antimicrobial activity and is effective against a variety of Gram-positive and Gram-negative bacteria. Cefonicid monosodium can be used for research on infections.
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Relebactam-d9
0 ImagesCat. No.: HY-16752S1Synonyms: MK-7655-d9Relebactam-d9 (MK-7655-d9) is deuterium labeled Relebactam. Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases and KPC) and class C (AmpC) enzymes. Relebactam shows antibacterial activity.
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Cefotaxime-d3 sodium
0 ImagesCat. No.: HY-A0088SSynonyms: Cefotaxim-d3 sodium; HR-756-d3 sodiumCefotaxime-d3 (sodium) is the deuterium labeled Cefotaxime (sodium salt). Cefotaxime sodium salt, a β-lactamase stable cephalosporin and a third-generation cephalosporin antibiotic, possesses broad-spectrum antibiotic activity against numerous Gram-positive and Gram-negative bacteria.
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Carpetimycin A
0 ImagesCat. No.: HY-N13977CAS No.: 76025-73-5Carpetimycin A has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin A has a strong inhibitory effect on β-lactamase.
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BLI-489 (Standard)
0 ImagesCat. No.: HY-108062RCAS No.: 623564-40-9BLI-489 Standard is the analytical standard of BLI-489 (HY-108062). This product is intended for research and analytical applications. BLI-489 is a Beta-lactamase inhibitor. BLI-489 is an antibacterial adjuvant that significantly enhances the antibacterial efficacy of β-lactam antibiotics. BLI-489 blocks the hydrolytic activity of the enzyme by forming a stable intermediate in serine Beta-lactamase, or by coordinating with the binuclear Zn2+ through an oxygen atom in metallo-Beta-lactamase. BLI-489 can be used for research on bacterial infections.
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Carpetimycin C
0 ImagesCat. No.: HY-N13979CAS No.: 87695-64-5Carpetimycin C has very strong activity against Gram-positive and negative bacteria (including β-lactamase producing bacteria). Carpetimycin C has a strong inhibitory effect on β-lactamase.
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Tubacin (Standard)
0 ImagesCat. No.: HY-13428RCAS No.: 537049-40-4Tubacin (Standard) is the analytical standard of Tubacin. This product is intended for research and analytical applications. Tubacin is a potent and selective inhibitor of HDAC6, with an IC50 value of 4 nM and approximately 350-fold selectivity over HDAC1. Tubacin also inhibits metallo-β-lactamase domain-containing protein 2 (MBLAC2).
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MBL-IN-6
0 ImagesCat. No.: HY-175724MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with Kis of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research.
