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Cathepsin Related Products (183)
Related Products (183)
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PI3K-001
0 ImagesCat. No.: HY-181741PI3K-001 is a cathepsin B-responsive prodrug and antifibrotic agent. PI3K-001 undergoes cathepsin B-mediated cleavage of the Val-Ala linker in fibrotic lung lesions to release an active PI3K inhibitor payload, while it remains stable in healthy tissues. PI3K-001 improves collagen deposition, tissue collapse and alveolar injury in fibrotic lung tissues. PI3K-001 is applicable for the research of pulmonary fibrosis.
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Ctsb Rat Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03324Ctsb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Cathepsin K-IN-8
0 ImagesCat. No.: HY-177315CAS No.: 501126-27-8Cathepsin K-IN-8 (cxample 6-60) is a cathepsin K inhibitor that can be used for the study of inflammation, rheumatoid arthritis, osteoarthritis, osteoporosis and tumors.
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Cathepsin E substrate e
0 ImagesCat. No.: HY-P10922CAS No.: 1246741-19-4Cathepsin E substrate e is a substrate of Cathepsin E. Cathepsin E substrate e was designed in such a way that due to the close proximity of a Mca-donor and a Dnp-acceptor, a near complete intramolecular quenching effect was achieved in its intact state. After the proteolytic cleavage of the hydrophobic motif of the peptide substrate, both Mca and Dnp would be further apart, resulting in bright fluorescence.
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Anti-inflammatory agent 113
0 ImagesCat. No.: HY-181676Anti-inflammatory agent 113 (compound B5) is a Cathepsin L (CTSL) inhibitor and anti-inflammatory agent with a CTSL IC50 of 5.52 μM. Anti-inflammatory agent 113 suppresses CTSL maturation, attenuates NF-κB and p38 MAPK signaling pathway activation, and binds stably in CTSL’s active site via noncovalent interactions with Asp162, Cys25, and Glu63. Anti-inflammatory agent 113 inhibits pro-inflammatory cytokine (IL-6, IL-8) production, reduces inflammatory cell lung infiltration, and alleviates lung tissue injury. Anti-inflammatory agent 113 can be used for the research of acute lung injury.
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BJ-2302
0 ImagesCat. No.: HY-182614CAS No.: 1631056-29-5BJ-2302 is a Src kinase inhibitor with an IC50 of 3.23 μM, and inhibits cathepsin S (CTSS) activity.BJ-2302 binds to Src, suppresses PI3K/AKT and Ras/Raf/ERK pathways, and reduces CTSS and MMP-9 expression.BJ-2302 inhibits cancer cell invasion, metastasis, proliferation, and tumor growth.BJ-2302 does not induce cytotoxicity in normal breast epithelial cells.BJ-2302 can be used for the research of breast cancer and triple-negative breast cancer.
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CTSK Human Pre-designed siRNA Set A
0 ImagesCat. No.: HY-RS03337CTSK Human Pre-designed siRNA Set A contains three designed siRNAs for CTSK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Z-Nle-Lys-Arg-AMC
0 ImagesCat. No.: HY-155667CAS No.: 1135364-14-5Z-Nle-Lys-Arg-AMC is a fluorogenic peptide substrate that specifically monitors cathepsin B activity over a broad pH range.
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Poly-L-Glutamic acid (MW 100000)
0 ImagesCat. No.: HY-112111ACAS No.: 25513-46-6Poly-L-Glutamic acid (MW 100000) is a synthetic polypeptide with biocompatibility, biodegradability and non-immunogenicity. Poly-L-Glutamic acid is an ideal tumor-targeting polymer carrier. Poly-L-Glutamic acid can be hydrolyzed by cathepsin B during metabolic decomposition.
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Cathepsin C-IN-6
0 ImagesCat. No.: HY-155611Cathepsin C-IN-6 (compound 2) is a E-64c-hydrazideas based inhibitor of cathepsin C with anti-inflammatory activity. Cathepsin C-IN-6 inhibts activation of neutrophil elastase，exhibits potential efficacy in inflammatory diseases with high neutrophil load (e.g.，chronic obstructive pulmonary disease).
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Abz-GIVRAK(Dnp)
0 ImagesCat. No.: HY-P4404CAS No.: 827044-38-2Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal.
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Z-FG-NHO-Bz
0 ImagesCat. No.: HY-P5999CAS No.: 118292-22-1Z-FG-NHO-Bz is a selective cathepsin inhibitor.
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Dutacatib
0 ImagesCat. No.: HY-100701CAS No.: 501000-36-8Dutacatib is inhibitor for SARS-CoV-2 3CLpro and cathepsin K, which exhibits antiviral activity and ameliorates the cancer-induced bone diseases.
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AKR1C3-IN-17
0 ImagesCat. No.: HY-187527CAS No.: 3120497-79-9AKR1C3-IN-17 is a cathepsin B (CTSB)-activated small molecule-drug conjugate targeting AKR1C3 with an IC50 of 9 nM. AKR1C3-IN-17 is cleaved by CTSB to release the payload Gemcitabine (HY-17026). AKR1C3-IN-17 induces apoptosis and shows antitumor activity in mice. AKR1C3-IN-17 can be used for the study of hepatocellular carcinoma.
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CA-074 methyl ester (Standard)
0 ImagesSynonyms: CA-074Me (Standard)CA-074 methyl ester (Standard) is the analytical standard of CA-074 methyl ester (HY-100350). This product is intended for research and analytical applications. CA-074 methyl ester is a specific inhibitor of Cathepsin B, which has potent bioactivities such as neuroprotective, anti-cancer, and anti-inflamatory effects.
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Oxocarbazate
0 ImagesCat. No.: HY-139111CAS No.: 1014405-03-8Oxocarbazate is an inhibitor of human cathepsin L with the IC50 values of 6.9 nM (human Cathepsin L,0 h) 0.4 nM ((human Cathepsin L,4 h) and 5.07 μM (human cathepsin B), respectively. Oxocarbazate blockes both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into 293T cells.
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NCO 700 sulfate
0 ImagesCat. No.: HY-106058ACAS No.: 84579-82-8NCO-700 sulfate is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 sulfate reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 sulfate also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 sulfate can be used to study myocardial ischemia and refractory hormone-independent tumors.
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Z-LVG-CHN2 (Standard)
0 ImagesCat. No.: HY-108137RCAS No.: 119670-30-3Z-LVG-CHN2 (Standard) is the analytical standard of Z-LVG-CHN2 (HY-108137). This product is intended for research and analytical applications. Z-LVG-CHN2 is a cell-permeable and irreversible inhibitor of cysteine proteinase. Z-LVG-CHN2 is a tripeptide derivative and mimics part of the human cysteine proteinase-binding center. Z-LVG-CHN2 displays an inhibition on HSV whereas no significant effect on poliovirus replication. Z-LVG-CHN2 effectively blocks SARS-COV-2 replication (EC50=190 nM) via inhibition of SARS-COV-2 3CL pro protease.
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NC 2300
0 ImagesCat. No.: HY-15099CAS No.: 221144-20-3Synonyms: VEL 0230NC 2300 (VEL-0230)is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders.
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K11002 hydrobromide
0 ImagesCat. No.: HY-183387CAS No.: 1348565-08-1K11002 hydrobromide is a cysteine protease inhibitor. K11002 hydrobromide forms a covalent bond with the active site cysteine residue via Michael addition. K11002 hydrobromide inhibits the growth of Trypanosoma brucei. K11002 hydrobromide can be used in the research of African human trypanosomiasis (sleeping sickness).
