DNA Alkylator/Crosslinker
DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.
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DNA Alkylator/Crosslinker Inhibitors
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DNA Alkylator/Crosslinker Activator
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DNA Alkylator/Crosslinker Chemicals
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DNA Alkylator/Crosslinker Inducers
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DNA Alkylator/Crosslinker Controls
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DNA Alkylator/Crosslinker Ligand
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DNA Alkylator/Crosslinker Related Products (297)
Related Products (297)
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Antibodies (3)
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Duocarmycin MA
0 ImagesCat. No.: HY-18987CAS No.: 1613286-57-9Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.
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Prospidium dichloride
0 ImagesCat. No.: HY-W338604CAS No.: 23476-83-7Prospidium dichloride is a cationic cytostatic agent and anticancer agent.
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KW-2149
0 ImagesCat. No.: HY-119044CAS No.: 118359-59-4Synonyms: KT-6149KW-2149 (KT-6149) is a Mitomycin C (HY-13316) analogue activated by serum. KW-2149 can interact with DNA. KW-2149 exhibits antitumor activity. KW-2149 has pulmonary toxicity KW-2149 can be used for the research of cancer, such as leukemia.
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Bendamustine-d8
0 ImagesCat. No.: HY-13567S1CAS No.: 1134803-33-0Synonyms: SDX-105-d8 free baseBendamustine-d8 is the deuterium labeled Bendamustine. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties.
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Chlorambucil-d8-1
0 ImagesCat. No.: HY-13593S1CAS No.: 2733532-57-3Synonyms: CB-1348-d8-1; WR-139013-d8-1Chlorambucil-d8-1 is the deuterium labeled Chlorambucil. Chlorambucil (CB-1348), an orally active antineoplastic agent, is a bifunctional alkylating agent belonging to the nitrogen mustard group. Chlorambucil can be used for the research of lymphocytic leukemia, ovarian and breast carcinomas, and Hodgkin’s disease.
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Cystemustine
0 ImagesCat. No.: HY-106435CAS No.: 79955-36-5Cystemustine is a DNA inhibitor (a chloroethyl nitrosourea, CENU). Cystemustine can cause DNA cross-linking, thereby inhibiting the proliferation of tumor cells. Cystemustine can also exert cytotoxic effects by interfering with the cell cycle, inducing cell re-differentiation, and altering phospholipid metabolism. Cystemustine exhibits high anti-tumor activity and a relatively short plasma half-life in mice. Cystemustine can be used for the study of various malignant tumors, including melanoma, glioma, renal cancer, head and neck cancer, and colorectal cancer, etc.
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TPA(bi(Tos))-γ-Glu(PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682
0 ImagesCat. No.: HY-184522TPA (bi (Tos))-γ-Glu (PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 (Fig.4 B) is a conjugate of a toxin molecule and a linker, which can be used to synthesize ADCs. TPA (bi (Tos))-γ-Glu (PEG23)-Gly-Gly-Gly-C2-NH-PNU-159682 consists of the DNA alkylating/inserting agent PNU-159682 (HY-16700) and the linker (HY-184523).
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GMT 8 aptamer sodium
0 ImagesCat. No.: HY-160057GMT 8 aptamer sodium is a nucleic acid aptamer targeting different glioblastoma cell lines and exhibits high affinity. GMT 4 aptamer sodium also shows high binding affinity to the T lymphocyte cell line CCRF-CEM.
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Cyclophosphamide-d8
0 ImagesCat. No.: HY-17420S1CAS No.: 1178903-96-2Cyclophosphamide-d8 is deuterium labeled Cyclophosphamide. Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
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Losoxantrone
0 ImagesCat. No.: HY-106091CAS No.: 88303-60-0Synonyms: CI 941; DuP-941; BiantrazoleLosoxantrone (CI 941) is a DNA-binding agent. Losoxantrone has broad-spectrum antitumour activity. Losoxantrone induces dose-dependent leukopenia.
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Phenylacetic acid mustard
0 ImagesCat. No.: HY-136327CAS No.: 10477-72-2Phenylacetic acid mustard is the major metabolite of the cancer chemotherapeutic agent Chlorambucil (HY-13593). Chlorambucil is an alkylating agent with antitumor activity.
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Lexitropsin 1
0 ImagesCat. No.: HY-126782CAS No.: 123725-00-8Lexitropsin 1 is a DNA minor groove binder with a delta G degree of 65 kJ/mol at 303 K. Lexitropsin 1 has antiviral activity.
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QBS10072S dihydrochloride
0 ImagesCat. No.: HY-164401ACAS No.: 1802735-31-4QBS10072S dihydrochloride is a LAT1-selective substrate with blood-brain barrier permeability that inhibits tumor growth. QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces interstrand DNA cross-linking and cell apoptosis, and reduces leptomeningeal dissemination. QBS10072S dihydrochloride can be used in studies related to glioblastoma multiforme, diffuse intrinsic pontine glioma, triple-negative breast cancer brain metastases, and aggressive T-cell lymphoma.
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Guanidino-G-Clamp-PNA
0 ImagesCat. No.: HY-P11698CAS No.: 476667-31-9Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as miR-155 or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis.
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Prednimustine
0 ImagesCat. No.: HY-13732CAS No.: 29069-24-7Synonyms: Leo 1031; NSC 134087Prednimustine (Leo 1031;NSC 134087) is the ester formed from Prednisolone (HY-17463) and Chlorambucil (HY-13593). Prednimustine can be used for leukemias and lymphomas research.
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N-Nitroso-N-methylurea-d5
0 ImagesCat. No.: HY-W717139CAS No.: 2733722-92-2N-Nitroso-N-methylurea-d5 is the deuterium labeled N-Nitroso-N-methylurea (HY-34758). N-Nitroso-N-methylurea (NMU;MNU;NMH) is a potent carcinogen, mutagen and teratogenand. N-Nitroso-N-methylurea is a direct-acting alkylating agent that interacts with DNA. N-Nitroso-N-methylurea targets multiple animal organs to cause various cancer and/or degenerative disease. N-Nitroso-N-methylurea is also a precursor in the synthesis of diazomethane.
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Bendamustine-d7 hydrochloride
0 ImagesCat. No.: HY-W738282Synonyms: SDX-105-d7Bendamustine-d7 hydrochloride (SDX-105-d7) is the deuterium labeled Bendamustine hydrochloride (HY-B0077). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties.
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Tachyplesin II
0 ImagesCat. No.: HY-P11398Tachyplesin II is a broad-spectrum cationic antimicrobial peptide. Tachyplesin II has significant inhibitory effects on Gram-positive bacteria, Gram-negative bacteria, and some fungi. Tachyplesin II binds to bacterial membrane lipopolysaccharides through its positive charge, disrupting membrane integrity and causing leakage of cellular contents. Tachyplesin II can bind to DNA grooves, inhibiting microbial replication, and also suppressing HIV-1 replication and the proliferation of liver cancer cells.
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Cyclophosphamide-d8 hydrate
0 ImagesCat. No.: HY-17420ASSynonyms: Cyclophosphamide-d8 monohydrateCyclophosphamide-d8 (hydrate) is the deuterium labeled Cyclophosphamide hydrate. Cyclophosphamide hydrate is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
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MN33-47
0 ImagesCat. No.: HY-182759MN33-47 is a multi-target anti-tumor compound with broad-spectrum anti-proliferative activity. MN33-47 relieves the inhibition of the mitochondrial apoptosis pathway by downregulating the anti-apoptotic protein Bcl-2, while activating caspase-3 and inhibiting Topoisomerase I activity, thereby promoting its degradation through the ubiquitin-proteasome and autophagy-lysosome pathways. MN33-47 can also induce DNA cross-linking and G2/M cell cycle arrest, inhibit cancer cell migration and activate the mitochondrial apoptosis pathway, thus exerting potent anti-tumor effects. MN33-47 can improve the water solubility of SN-38 (HY-13704), and exhibits dose-dependent tumor growth inhibition effects in CT26 tumor-bearing mouse models without obvious toxic and side effects. MN33-47 can be used in related studies on colorectal adenocarcinoma, cervical adenocarcinoma, hepatocellular carcinoma, alveolar basal epithelial adenocarcinoma, gastric cancer and colon cancer.
