Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
All Product Categories
-
Drug Derivative Inhibitors
(12)
View all products
-
Drug Derivative Agonist
(1)
View all products
-
Drug Derivative Activator
(1)
View all products
-
Drug Derivative Chemical
(1)
View all products
-
Drug Derivative Inducer
(1)
View all products
-
Drug Derivative Controls
(38)
View all products
-
Drug Derivative Substrate
(1)
View all products
-
Drug Derivative Related Products (4062)
Related Products (4062)
-
Valsartan methyl ester (Standard)
0 ImagesSynonyms: CGP 48933 methyl ester (Standard)Valsartan (CGP 48933) methyl ester (Standard) is the analytical standard of Valsartan methyl ester (HY-W414915). This product is intended for research and analytical applications. Valsartan methyl ester is the methyl ester derivative of Valsartan (HY-18204). Valsartan is a selective angiotensin II type 1 (AT1) receptor blocker (ARB) with potent antihypertensive and cardioprotective effects. Valsartan competitively binds to AT1 receptors, inhibiting the binding of angiotensin II to AT1 receptors, thereby blocking angiotensin II-mediated vasoconstriction, sodium retention, and myocardial hypertrophy signaling pathways. Valsartan reduces systolic blood pressure in L-NAME-induced hypertensive rats. Valsartan can be used for the study and treatment of arterial hypertension, hypertensive heart disease, and heart failure.
-
N-Glycine globotriaosylsphingosine (d18:1)
0 ImagesCat. No.: HY-125162CAS No.: 1360882-59-2N-Glycine globotriaosylsphingosine (d18:1) is a glycosphingolipid.
-
Phenyl salicylate (Standard)
0 ImagesPhenyl salicylate (Standard) is the analytical standard of Phenyl salicylate (HY-B1731). This product is intended for research and analytical applications. Phenyl salicylate is an ester derivative of Salicylic acid (HY-B0167) that exhibits no antimycobacterial activity. Phenyl salicylate can cross-sensitize with Resorcinol monobenzoate. Phenyl salicylate is used in research related to contact dermatitis.
-
Mayumbine
0 ImagesCat. No.: HY-N3311CAS No.: 25532-45-0Synonyms: 19-EpiajmalicineMayumbine (19-Epiajmalicine) is a natural alkaloid.
-
Cadralazine (Standard)
0 ImagesCat. No.: HY-106538RCAS No.: 64241-34-5Synonyms: ISF 2469 (Standard)Cadralazine (Standard) is the analytical standard of Cadralazine. This product is intended for research and analytical applications. Cadralazine (ISF 2469) is an orally active antihypertensive agent. Cadralazine is a peripheral arteriolar vasodilator.
-
Dixyrazine (Standard)
0 ImagesCat. No.: HY-U00153RCAS No.: 2470-73-7Dixyrazine (Standard) is the analytical standard of Dixyrazine. This product is intended for research and analytical applications. Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.
-
Isomangiferin (Standard)
0 ImagesCat. No.: HY-N0772RCAS No.: 24699-16-9Isomangiferin (Standard) is the analytical standard of Isomangiferin (HY-N0772). This product is intended for research and analytical applications. Isomangiferin is an orally active xanthone C-glucoside, and its chemical structure is similar to Mangiferin (HY-N0290). Isomangiferin is an effective VEGFR-2 kinase inhibitor, which can induces cell apoptosis, inhibit the growth, metastasis and angiogenesis of breast cancer. Isomangiferin exerts anti-inflammatory effects by inhibiting the HMGB1/NLRP3/NF-κB signaling pathway, thereby improving the renal function indicators of diabetic mice. Isomangiferin exhibits inhibitory effects on various bacteria and herpes simplex virus type 1 (HSV-1). Isomangiferin promotes the migration and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and reduces cell apoptosis and the production of ROS by activating the AMPK/ACC pathway, thereby facilitating fracture healing.
-
3-Methyl-L-tyrosine
0 ImagesCat. No.: HY-W114420CAS No.: 17028-03-43-Methyl-L-tyrosine is a derivative of L-Tyrosine (HY-N0473). Structurally, 3-Methyl-L-tyrosine features a methyl modification at the third position of the aromatic ring of L-Tyrosine. As a substrate for the protein tyrosine kinase Csk, 3-Methyl-L-tyrosine's relative catalytic efficiency (kcat/Km) is 38% of L-Tyrosine, indicating that the methyl modification impacts the processing efficiency of Gsk significantly. 3-Methyl-L-tyrosine helps to deepen the understanding of Gsk's molecular recognition mechanisms of its substrates, which is crucial for developing specific inhibitors targeting Gsk.
-
β-Nornicotyrine
0 ImagesCat. No.: HY-W588203CAS No.: 494-98-4Synonyms: 3-(1H-Pyrrol-2-yl)pyridineβ-Nornicotyrine (3-(1H-Pyrrol-2-yl)pyridine) is an alkaloid that has been found in N. tabacum. β-Nornicotyrine can be used for research on neurological diseases.
-
Ascr#12
0 ImagesCat. No.: HY-171720CAS No.: 1355681-43-4Synonyms: Asc-C6Ascr#12 (Asc-C6) is an ascaroside derivative that exhibits extremely low activity in inducing the dauer (dormant larval) stage. Ascr#12 enhances the reproductive capacity of the invasive pine wood nematode.
-
Nifoxipam
0 ImagesCat. No.: HY-121478CAS No.: 74723-10-7Nifoxipam is a nitrobenzodiazepine.
-
Tosyl-methamphetamine
0 ImagesCat. No.: HY-170730CAS No.: 74810-23-4Synonyms: TS-MethamphetamineTosyl-methamphetamine (TS-Methamphetamine) is an amphetamine.
-
Cyclophosphamide impurity 2
0 ImagesCat. No.: HY-W587445CAS No.: 158401-52-6Cyclophosphamide impurity 2 is a hydrolysis product of Cyclophosphamide (HY-17420). Cyclophosphamide impurity 2 can be used for the research of leukemia.
-
α-Pyrrolidino-2-phenylacetophenone hydrochloride
0 ImagesCat. No.: HY-168811CAS No.: 27590-61-0α-Pyrrolidino-2-phenylacetophenone hydrochloride is a drug derivative.
-
N-Methyl Homarylamine hydrochloride
0 ImagesCat. No.: HY-168426CAS No.: 136366-39-7N-methyl Homarylamine hydrochloride is a phenethylamine.
-
10-PAHSA
0 ImagesCat. No.: HY-133851CAS No.: 1636134-73-010-PAHSA is a fatty ester.
-
3,4-Dimethoxy-α-pyrrolidinohexanophenone hydrochloride
0 ImagesCat. No.: HY-172065CAS No.: 2748409-11-03,4-Dimethoxy-α-pyrrolidinohexanophenone hydrochloridee is an analog of 3,4-Methylenedioxy pyrovalerone.
-
2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium
0 ImagesCat. No.: HY-174120CAS No.: 3056945-18-4Synonyms: 2-Thio-dCTP tetralithium2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium (2-Thio-dCTP tetralithium) is a dCTP (HY-101400A) analog that serves as a substrate for Sulfolobus solfataricus DNA polymerase Dpo4. 2-Thio-2'-deoxycytidine-5'-triphosphate tetralithium incorporates opposite G and O6-MeG templates, exhibiting improved selectivity for O6-MeG relative to dCTP without significant loss of incorporation efficiency.
