Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4062)
Related Products (4062)
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3'-TBS-OMe-Bz-rA
0 ImagesCat. No.: HY-W1008069CAS No.: 454424-09-03'-TBS-OMe-Bz-rA is an adenosine derivative. 3'-TBS-OMe-Bz-rA can be used as an intermediate in the synthesis of modified oligonucleotides or other nucleic acid-related molecules.
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Dimethyl octanedioate
0 ImagesSynonyms: Suberic acid dimethylesterDimethyl octanedioate (Suberic acid dimethylester) is an ester product.
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13,14-Dihydro-19(R)-hydroxy prostaglandin E1
0 ImagesCat. No.: HY-158808CAS No.: 2108853-39-813,14-dihydro-19(R)-hydroxy Prostaglandin E1 is the theoretical metabolite of 13,14-dihydro PGE1 by ω-1 hydroxylase.
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(Rac)-Azide-deoxy-ascomycin-O-ethylene
0 ImagesCat. No.: HY-180122CAS No.: 146877-36-3(Rac)-Azide-deoxy-ascomycin-O-ethylene, a nitrogen-containing compound, is a derivative of a macrolide-type immunosuppressant.
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4-DMA-3'-OH-Chalcone
0 ImagesCat. No.: HY-181637CAS No.: 946437-21-44-DMA-3'-OH-Chalcone (compound 24) is a synthetic chalcone derivative and selective cytotoxic agent.4-DMA-3'-OH-Chalcone reduces viability of endometriotic cells, while preserving or enhancing viability of eutopic endometrial cells.4-DMA-3'-OH-Chalcone can be used for the research of endometriosis.
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Tricrozarin A
0 ImagesCat. No.: HY-N15334CAS No.: 107817-60-7Tricrozarin A is a Naphthazarin (HY-N7526) derivative, which is found in fresh bulbs of Tritonia crocosmaeflora. Tricrozarin A exhibits antimicrobial activity against gram-positive bacteria, fungi, and yeast.
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2,5-Epidithia-3,6-dioxopiperazine
0 ImagesCat. No.: HY-177477CAS No.: 21056-79-12,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research.
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10(S)-Hydroxystearic acid
0 ImagesCat. No.: HY-W983371ACAS No.: 67042-09-5Synonyms: (S)-10-Hydroxyoctadecanoic acid; (S)-10-HSA10(S)-Hydroxystearic acid ((S)-10-Hydroxyoctadecanoic acid; (S)-10-HSA) is a hydroxy fatty acid and a derivative of Oleic acid (HY-N1446). 10(S)-Hydroxystearic acid can be used for the research of infection.
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Glyasperin M
0 ImagesCat. No.: HY-N19004CAS No.: 156162-05-9Glyasperin M is an isoflavanone found in Glycyrrhiza aspera.
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Methamphetamine ethyl carbamate
0 ImagesCat. No.: HY-170736CAS No.: 120504-67-8Methamphetamine ethyl carbamate is an amphetamine. This product is intended for research and forensic applications.
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(5RS)-Pyridinoline
0 ImagesCat. No.: HY-W739246Purity: 99.37%(5RS)-Pyridinoline is one of the stereoisomers of pyridinoline-type collagen crosslinkers.
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Nat 20(S)-yne
0 ImagesCat. No.: HY-138894CAS No.: 1397692-46-4Nat 20(S)-yne is a steroid with an alkyne group at the terminal end, and it can be used in click chemistry reactions.
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DHEA Benzophenone-biotin
0 ImagesCat. No.: HY-183342CAS No.: 1216903-70-6DHEA Benzophenone-biotin is a photoactive DHEA (HY-14650) analog containing Biotin (HY-B0511) and Benzophenone (HY-Y0546) groups. DHEA Benzophenone-biotin inhibits plasma membrane binding of DHEA, activates endothelial NO synthase. DHEA Benzophenone-biotin cross-links to plasma membrane DHEA binding sites upon UV irradiation to identify associated proteins.
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4-Chloroethamphetamine hydrochloride
0 ImagesCat. No.: HY-170735CAS No.: 54779-54-34-Chloroethamphetamine hydrochloride is an amphetamine.
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Deacetyl acebutolol
0 ImagesCat. No.: HY-187682CAS No.: 27783-53-5Deacetyl acebutolol is a disinfection by-product and in vivo deacetylated metabolite of Acebutolol (HY-17497). Deacetyl acebutolol is generated from Acebutolol via a series of reactions including chlorination, dealkylation, hydroxylation and oxidation. In vivo, Deacetyl acebutolol is produced by the carboxylesterase CES2-catalyzed hydrolysis of Acebutolol. Deacetyl acebutolol can be used in the research of arrhythmia .
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2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A
![2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A](https://file.medchemexpress.com/product_pic/hy-p11545.gif "Click to View 2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A Product Detail")
0 ImagesCat. No.: HY-P11545CAS No.: 164028-89-12-[O-(2-Azidoethyl)-D-serine]-cyclosporin A (Compound 33) is a Cyclosporine derivative. 2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A shows an IC50 of 0.11 μg/mL in the mixed lymphocyte reaction.
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Chondroitin sulfate-cholesterol
0 ImagesCat. No.: HY-185474Chondroitin sulfate-cholesterol is a cholesterol derivative. Chondroitin sulfate-cholesterol can form reduction-responsive shell-sheddable micelles via disulfide bond linkage and be used to efficiently encapsulate hydrophobic drugs and achieve intracellular triggered release. Chondroitin sulfate-cholesterol can be used for cancer research.
