Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Omeprazole sulfone-13C,d3
0 ImagesCat. No.: HY-G0007S1CAS No.: 1261393-28-5Synonyms: Omeprazole sulfone-13C,d3; Omeprazole sulphone-13C,d3Omeprazole sulfone-13C,d3 is the deuterium and 13C labeled Omeprazole sulfone. Omeprazole sulfone (Omeprazole sulphone) is one of the major circulating metabolites of Omeprazole (HY-B0113) in vivo, and belongs to class 4 non-mutagenic impurities. Omeprazole sulfone does not bind to the aryl hydrocarbon receptor (AhR), nor does it induce the expression of CYP1A1 or CYP1A2. However, Omeprazole sulfone promotes the migration of gastric epithelial cells under basal conditions and reverses the inhibitory effect of Indomethacin (HY-14397) on cell migration. Omeprazole sulfone does not promote cell proliferation, nor does it upregulate COX-2 expression or activate signaling pathways such as ERK, P38 MAPK and PI3K. Omeprazole sulfone maintains basal ulcer healing under non-acid-dependent conditions and can be used in studies related to gastric ulcer repair.
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Atorvastatin acetonide
0 ImagesCat. No.: HY-135379CAS No.: 581772-29-4Atorvastatin acetonide is an impurity of Atorvastatin, and extracted from patent WO2011131605A1, Compound 4. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids.
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Dimesna-d8
0 ImagesCat. No.: HY-W699643CAS No.: 1189975-43-6Synonyms: BNP-7787-d8Dimesna-d8 (BNP-7787-d8) is the deuterium labeled Dimesna (HY-B1022). Dimesna combined with anticancer chemotherapeutic agents to reduce nephrotoxicity.
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Cinacalcet metabolite M4
0 ImagesCat. No.: HY-135601CAS No.: 104774-87-0Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease.
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PSI-7410 sodium
0 ImagesCat. No.: HY-171362APSI-7410 sodium is the ametabolite of Sofosbuvir (HY-15005). PSI-7410 sodium can be metabolized to PSI-7409 (HY-15745) by nucleoside diphosphate kinase. PSI-7410 sodium is promising for research of anti-hepatitis C agent.
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DM50 impurity 1-d9
0 ImagesCat. No.: HY-143986SDM50 impurity 1-d9 is the deuterium labeled DM50 impurity 1.
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(R)-tert-OMe-byakangelicin
0 ImagesCat. No.: HY-N9535ACAS No.: 89560-97-4(R)-tert-OMe-byakangelicin is a kind of furanocoumarin, which has inhibitory activity to liver drug metabolizing enzyme (DME) activity. (R)-tert-OMe-byakangelicin can be isolated from immature fruits of Angelica sinensis.
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16-Phenyl tetranor Prostaglandin F2α
0 ImagesCat. No.: HY-137544CAS No.: 38315-48-9Synonyms: 16-Phenyl tetranor PGF2α16-phenyl tetranor Prostaglandin F2α (16-phenyl tetranor PGF2α) is a metabolically stable analog of PGF2α. The affinity of 16-phenyl tetranor PGF2α at the FP receptor of ovine luteal cells is poor (8.7%) compared to PGF2α.
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LL-340001
0 ImagesCat. No.: HY-187702CAS No.: 2046137-49-7LL-340001 is the receptor-active metabolite released after hydrolysis of Elunetirom (HY-160207) by FAAH in the central nervous system. LL-340001 acts as a thyroid hormone receptor (TR) agonist, with potent full agonist activity at both TRα and TRβ. LL-340001 exhibits neuronal plasticity activity and can activate programs related to neuroplasticity and mitochondrial biogenesis in neuronal systems. LL-340001 can be used in the research of major depressive disorder and bipolar depression.
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6-Raloxifene-β-D-glucopyranoside
0 ImagesCat. No.: HY-135595CAS No.: 334758-18-86-Raloxifene-β-D-glucopyranoside, a derivative of Raloxifene, is a benzothiophene glucuronidated at the 6' postion. 6-Raloxifene-β-D-glucopyranoside is a selective and orally active estrogen receptor antagonist. 6-Raloxifene-β-D-glucopyranoside can be used for inhibiting bone loss and resorption, and lowering lipid levels. 6'-Raloxifene-β-D-glucopyranoside, compound Ia, is extracted from patent US5567820A.
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Terbuthylazine-desethyl (Standard)
0 ImagesCat. No.: HY-136445RCAS No.: 30125-63-4Synonyms: Desethylterbuthylazine (Standard)Terbuthylazine-desethyl (Standard) is the analytical standard of Terbuthylazine-desethyl. This product is intended for research and analytical applications. Terbuthylazine-desethyl (Desethylterbuthylazine) is a chloro dealkylated metabolite of Terbuthylazine (a triazine herbicide).
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Amlodipine aspartic acid impurity (Standard)
0 ImagesCat. No.: HY-128696RCAS No.: 400602-35-9Synonyms: Amlodipine aspartate (Standard)Amlodipine aspartic acid impurity (Amlodipine aspartate) (Standard) is the analytical standard of amlodipine aspartic acid impurity. This product is intended for research and analytical applications. Amlodipine aspartic acid impurity is the impurity of Amlodipine aspartic acid. Amlodipine aspartic acid is a calcium channel blocker with antihypertensive and antianginal properties. Amlodipine aspartic acid impurity can control blood pressure. Amlodipine aspartic acid impurity corrects gut dysbiosis and enhances taurine and hypotaurine metabolism. Amlodipine aspartic acid impurity can be studied in research for NAFLD and hypertension.
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(±)7(8)-EpDTE
0 ImagesCat. No.: HY-139268CAS No.: 1616607-36-3(±)7(8)-EpDTE is an oxylipin and an oxidative metabolite of docosapentaenoic acid.
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3α-Hydroxy pravastatin sodium
0 Images3α-Hydroxy pravastatin sodium is the major metabolite of Pravastatin (HY-B0165A). Pravastatin is a competitive HMG-CoA reductase inhibitor.
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Plucheoside B aglycone
0 ImagesCat. No.: HY-N9816CAS No.: 393862-19-6Plucheoside B (Compound 7b) aglycone is an aglycone of plucheoside B with an absolute configuration of 3R, 4R, and 9R that can be isolated from the leaves of Croton cascarilloides Räuschel.
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Etilevodopa (Standard)
0 ImagesCat. No.: HY-116016RCAS No.: 37178-37-3Synonyms: L-DOPA ethyl ester (Standard); Levodopa ethyl ester (Standard)Chlorbenside (Standard) is the analytical standard of Chlorbenside. This product is intended for research and analytical applications. Chlorbenside is an organochlorine pesticide. Chlorbenside targets organism such as mites and ticks and possesses efficient ovicidal and larvicidal activities.
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Propylene thiourea-d6
0 ImagesCat. No.: HY-W743390CAS No.: 2512193-20-1Synonyms: 4-Methylimidazolidine-2-thione-d6
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5,6-Epoxy-13-cis retinoic acid
0 ImagesCat. No.: HY-119359CAS No.: 81444-57-7Synonyms: Isotretinoin EP impurity G5,6-Epoxy-13-cis retinoic acid (Isotretinoin EP impurity G) is a metabolite of 13-cis retinoic acid.
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Atorvastatin EP impurity H-d5
0 ImagesCat. No.: HY-143907S
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3-O-Methyltolcapone-d4
0 ImagesCat. No.: HY-100642S1CAS No.: 2469274-07-3Synonyms: Ro 40-7591-d43-O-Methyltolcapone-d4 (Ro 40-7591 d4) is a deuterium labeled 3-O-Methyltolcapone (HY-174062). 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
