Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
All Product Categories
-
Drug Metabolite Related Products (2022)
Related Products (2022)
-
Antibodies (1)
-
Related Compound Screening Libraries (1)
-
Cordybislactone hydrolyzed derivative-1
0 ImagesCat. No.: HY-N19150CAS No.: 2227456-72-4Cordybislactone hydrolyzed derivative-1 (Compound 4) is a C-7 ester hydrolyzed derivative of Cordybislactone that can be found in the hopper pathogenic fungus Cordyceps sp. BCC 49294.
-
Desmethylnortriptyline
0 ImagesDesmethylnortriptyline is a metabolite of Nortriptyline (HY-118620). Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline (HY-B0527) , and is used to relieve the symptoms of depression.
-
Pitavastatin lactone (Standard)
0 ImagesCat. No.: HY-125643RCAS No.: 141750-63-2Tobramycin (Standard) is the analytical standard of Tobramycin. This product is intended for research and analytical applications. Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms.Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa.
-
15-Keto-prostaglandin E2-d9
0 Images15-Keto-prostaglandin E2-d9 is the d9 labeled 15-keto-Prostaglandin E2 (HY-113205). 15-keto-Prostaglandin E2 (15-keto-PGE2) is an endogenous PGE2 metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to the Cys259 residue of STAT3. 15-keto-Prostaglandin E2 binds to and stabilizes EP2 and EP4 receptors. 15-keto-Prostaglandin E2 inhibits the growth and progression of breast cancer cells. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth. 15-keto-Prostaglandin E2 disrupts glomerular vascularization during zebrafish development and reduces the surface area of the glomerular filtration barrier.
-
4-Methylamino antipyrine hydrochloride
0 ImagesCat. No.: HY-135731ACAS No.: 856307-27-24-Methylamino antipyrine hydrochloride is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. Metamizole is an nonopioid analgesic agent and can be used for pain and fever. 4-Methylamino antipyrine hydrochloride has analgesic, antipyretic, and relatively weak antiinflammatory properties.
-
PX5–9
0 ImagesCat. No.: HY-174337PX5-9 is an orally active prodrug that can upregulate brain-derived neurotrophic factor (BDNF). PX5–9 exerts neuroprotective effects by elevating intracellular BDNF levels. PX5-9 can be used for the research of neurodegenerative diseases (such as Alzheimer's disease, Parkinson's disease) and depression, which are associated with reduced BDNF levels.
-
3-Hydroxyflunitrazepam
0 ImagesCat. No.: HY-121057CAS No.: 67739-71-3Synonyms: 3-OH FNTZ3-Hydroxyflunitrazepam (3-OH FNTZ) is the major metabolite of Flunitrazepam (FNTZ), generated via 3-hydroxylation by CYP3A4 (Km = 286 μM), and represents the dominant metabolic pathway (>80%) in liver microsomes. Its formation is significantly inhibited by CYP3A4 inhibitors such as Ketoconazole (HY-B0105) (IC50 = 0.11 μM) and Ritonavir (HY-90001) (IC50 = 0.041 μM), indicating a strong dependence on CYP3A4 activity and potential drug interactions.
-
(S)-Nornicotine hydrochloride
0 ImagesCat. No.: HY-W040430ACAS No.: 101832-65-9(S)-Nornicotine hydrochloride is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine hydrochloride weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine hydrochloride promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine hydrochloride reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine hydrochloride is useful for research on tobacco dependence and pain.
-
Apovincaminic acid hydrochloride salt (Standard)
0 ImagesCat. No.: HY-133813ARCAS No.: 72296-47-0Apovincaminic acid hydrochloride salt (Standard) is the analytical standard of Apovincaminic acid hydrochloride salt (HY-133813A). This product is intended for research and analytical applications. Apovincaminic acid hydrochloride salt is the major metabolite of Vinpocetine (HY-13295), with blood-brain barrier permeability and oral activity. Apovincaminic acid hydrochloride salt is detectable in the plasma of pregnant rabbits after oral administration of Vinpocetine. Apovincaminic acid hydrochloride salt is absorbable from all segments of the gastrointestinal tract of Norway rat, with the stomach as the primary absorption site, and is excreted via urine and feces. Apovincaminic acid hydrochloride salt is used in the research of cerebrovascular diseases.
-
T-705RMP
0 ImagesCat. No.: HY-136498CAS No.: 356783-08-9T-705RMP, a phosphorylated metabolite of T-705, exhibits a very weak inhibitory effect on the IMP dehydrogenase (IMPDH) activities of the host cells, with an IC50 of 601 μM.
-
Hydroxydehydro Nifedipine Carboxylate
0 ImagesCat. No.: HY-139428CAS No.: 34783-31-8Hydroxydehydro Nifedipine Carboxylate is an inactive metabolite formed by the oxidative biotransformation of Nifedipine (HY-B0284) in the human body.
-
DDC 3′-O-β-D glucuronide
0 ImagesCat. No.: HY-156180DDC 3′-O-β-D glucuronide (compound 5) is a drug metabolite that can prevent the fibrillization and oligomerization of Aβ42. DDC 3′-O-β-D glucuronide has potential for the research of Alzheimer's disease.
-
Isocorybulbine
0 ImagesCat. No.: HY-N11827CAS No.: 22672-74-8Synonyms: (+)-IsocorybulbineIsocorybulbine ((+)-Isocorybulbine) is one of the main metabolites of Corydaline (HY-N0923) in human liver microsomes and liver cells. Corydaline has anti-acetylcholinesterase, anti-allergic, anti-allergic reaction and gastric emptying activities. Isocorybulbine can be used for the metabolic study of Corydaline.
-
2-Hydroxy Ibuprofen
0 ImagesCat. No.: HY-126121CAS No.: 51146-55-5Synonyms: (±)-2-Hydroxy Ibuprofen2-Hydroxy Ibuprofen ((±)-2-Hydroxy Ibuprofen) is a major oxidative metabolite of Ibuprofen (HY-78131). 2-Hydroxy Ibuprofen undergoes phase II metabolism, forming a β-1-O-acyl glucuronide conjugate at the carboxyl group of its propionic acid side chain. 2-Hydroxy Ibuprofen can be used for metabolism-related research.
-
N4-Acetylsulfamethoxazole (Standard)
0 ImagesCat. No.: HY-W013266RCAS No.: 21312-10-7Synonyms: Acetylsulfamethoxazole (Standard)N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) Standard of N4-Acetylsulfamethoxazole (HY-W013266). This product is intended for research and analytical applications. N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is the N4-acetylated metabolite of Sulfamethoxazole (HY-B0322).
-
Rivastigmine metabolite (Standard)
0 ImagesSynonyms: NAP 226-90 (Standard)Rivastigmine metabolite (Standard) is the analytical standard of Rivastigmine metabolite. This product is intended for research and analytical applications. Rivastigmine metabolite (NAP 226-90) is a metabolite produced by the hydrolysis of Rivastigmine (HY-17368). Rivastigmine metabolite serves as a surrogate marker to track the bioavailability, metabolic extent, and transdermal patch delivery rate of Rivastigmine.
-
5-(3-hydroxyphenyl)-5-phenylhydantoin
0 ImagesCat. No.: HY-145671CAS No.: 30074-03-45-(3-hydroxyphenyl)-5-phenylhydantoin, is a metabolite of anti-seizure agent Phenytoin.
-
6-Hydroxymelatonin glucuronide
0 ImagesCat. No.: HY-W718678CAS No.: 94840-69-4
-
β-Benzamide adenine dinucleotide
0 ImagesCat. No.: HY-147342CAS No.: 156724-91-3β-Benzamide adenine dinucleotide is a biologically active metabolite of benzamide riboside. β-Benzamide adenine dinucleotide is a competitive inhibitor of human NAD kinase with a Ki value of 90 μM, and inhibits human IMPDH with IC50 values of 0.787 μM and 0.884 μM for type I and type II, respectively. β-Benzamide adenine dinucleotide exhibits inhibitory activities against lactate dehydrogenase, glutamate dehydrogenase, and malate dehydrogenase. β-Benzamide adenine dinucleotide can be used for the study of chronic myelogenous leukemia.
-
Cidofovir diphosphate-13C3
0 ImagesCat. No.: HY-131606SCidofovir diphosphate-13C3 is the 13C-labeled Cidofovir diphosphate (HY-131606). Cidofovir diphosphate is the intracellular active metabolite of Cidofovir (HY-17438) and its oral prodrug Brincidofovir (HY-14532). By inhibiting viral DNA polymerase (Ki ≈ 76.3 μM), cidofovir diphosphate is widely used in studies on double-stranded DNA virus infections, including cytomegalovirus (CMV), adenovirus (AdV), and poxviruses (such as monkeypox and molluscum contagiosum virus, MCV).
