Drug Metabolite
Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
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Drug Metabolite Related Products (2022)
Related Products (2022)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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N-Formylsarcolysine
0 ImagesCat. No.: HY-147327CAS No.: 26367-45-3N-Formylsarcolysine has antitumor activity, and inhibits leukemia by increasing the Hb and erythrocyte levels and decreasing the number of leukocytes. N-Formylsarcolysine also involves in glioblastoma and other diseases research.
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Norfluoxetine hydrochloride (Standard)
0 ImagesCat. No.: HY-W011235RCAS No.: 57226-68-3Norfluoxetine hydrochloride (Standard) is the analytical standard of Norfluoxetine hydrochloride (HY-W011235). This product is intended for research and analytical applications. Norfluoxetine hydrochloride is the active metabolite of the antidepressant Fluoxetine (HY-B0102); it is also a TREK-2 K2P potassium channel inhibitor. Norfluoxetine hydrochloride exhibits neuroimmunological activity, induces apoptosis in primary microglial cells, and inhibits the release of pro-inflammatory factors. Norfluoxetine hydrochloride inhibits high-threshold voltage-gated Ca2+ currents in neurons with an EC50 of 20.4 μM. Norfluoxetine hydrochloride can be used in research related to depression, ischemic stroke, and epilepsy.
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OR-1855 (Standard)
0 ImagesOR-1855 (Standard) is an analytical standard of OR-1855 (HY-W050000). This product is intended for research and analytical applications. OR-1855, an active metabolite of Levosimendan (HY-14286), has effect on myometrial contractility. OR-1855 exerts anti-inflammatory effects by inhibiting IL-1β-induced ROS formation and NAD(P)H oxidase-dependent superoxide radical generation in HUVECs. OR-1855 inhibits IL-1β-induced phosphorylation p38 MAPK, ERK1/2, c-Jun and JNK in HUVECs. OR-1855 can be used for the study of inflammation.
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N-Methyl pemetrexed
0 ImagesCat. No.: HY-137773CAS No.: 869791-42-4N-Methyl pemetrexed is an impurity of Pemetrexed. Pemetrexed is an antifolate cytotoxic agent that can be used for the research of cancer.
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Tetranor-PGAM
0 ImagesCat. No.: HY-118548CAS No.: 52510-53-9Tetranor-PGAM is a tetranor-prostaglandin A metabolite. Tetranor-PGAM is a dehydration product of tetranor-PGEM (HY-114988). Tetranor-PGAM can be measured as a surrogate for tetranor-PGEM levels in urine.
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Apovincaminic acid
0 ImagesCat. No.: HY-133813CAS No.: 27773-65-5Apovincaminic acid is the major metabolite of Vinpocetine (HY-13295), with blood-brain barrier permeability and oral activity. Apovincaminic acid is detectable in the plasma of pregnant rabbits after oral administration of Vinpocetine. Apovincaminic acid is absorbable from all segments of the gastrointestinal tract of Norway rat, with the stomach as the primary absorption site, and is excreted via urine and feces. Apovincaminic acid is used in the research of cerebrovascular diseases.
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Calcitriol-d9
0 ImagesCat. No.: HY-10002S2CAS No.: 1539301-39-7Synonyms: 1,25-Dihydroxyvitamin D3-d9Calcitriol-d9 (1,25-Dihydroxyvitamin D3-d9) is the deuterium labeled Calcitriol (HY-10002). Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
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(±)-Nornicotine-d7
0 ImagesCat. No.: HY-W002112S1Synonyms: Nornicotine-d7(±)-Nornicotine-d7 is the deuterium labeled (±)-Nornicotine (HY-W002112). (±)-Nornicotine is a major metabolite of Nicotine. (±)-Nornicotine is a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. (±)-Nornicotine disrupts β-catenin and ZO-1, and induces F-actin depolymerization. (±)-Nornicotine supports self-administration behavior. (±)-Nornicotine can be used in the research of atherosclerosis, Alzheimer's disease, and schizophrenia.
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3β-Ursodeoxycholic acid (Standard)
0 ImagesSynonyms: Isoursodeoxycholic acid (Standard)3β-Ursodeoxycholic acid (Standard) is the analytical standard of 3β-Ursodeoxycholic acid. This product is intended for research and analytical applications. 3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid shows good tolerance and well intestinal absorption by oral adminstation. 3β-Ursodeoxycholic acid can be isomerized by intestinal and hepatic enzymes to yield UDCA.
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Mianserin EP impurity E-d4 (hydrochloride)
0 ImagesCat. No.: HY-143982SSynonyms: Desmethylmianserin-d4 hydrochloride
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7-Aminoflunitrazepam
0 ImagesCat. No.: HY-116687CAS No.: 34084-50-97-Aminoflunitrazepam is the main urinary metabolite of Flunitrazepam.
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19(R),20(S)-EDP
0 ImagesCat. No.: HY-157690ACAS No.: 2242542-60-319(R),20(S)-EDP (compound 19(S),20(R)-2a) is an oxylipin and a metabolite of docosahexaenoic acid (HY-B2167).
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7-Aminonimetazepam-d3
0 ImagesCat. No.: HY-W741628CAS No.: 1346603-85-77-Aminonimetazepam-d3 is the deuterium labeled 7-Aminonimetazepam (HY-W088846). 7-Aminonimetazepam is the metabolite of Nimetazepam, which is found in the urine.
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2-(1-Piperazinyl)pyrimidine-d8
0 ImagesCat. No.: HY-W004464SCAS No.: 1309283-31-52-(1-Piperazinyl)pyrimidine-d8 is the deuterated-labeled 2-(1-Piperazinyl)pyrimidine (HY-W004464). 2-(1-Piperazinyl)pyrimidine is an orally effective α2-adrenoceptor antagonist and 5-HT1A receptor agonist. 2-(1-Piperazinyl)pyrimidine is an in vivo metabolite related to buspirone. 2-(1-Piperazinyl)pyrimidine modulates excitatory synaptic transmission in the hippocampus and the release of monoamine transmitters such as norepinephrine and 5-HT by blocking α2-adrenoceptor and activating 5-HT1A Receptor. 2-(1-Piperazinyl)pyrimidine is used in research on psychiatric disorders such as anxiety and depression.
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Org-9768
0 ImagesCat. No.: HY-W223348CAS No.: 759424-59-4Org-9768 (Compound (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine) is a drug intermediate for synthesizing the mitochondrial permeability transition pore (mPTP) inhibitor. Org-9768 can be used for the researches of neurological and cardiovascular disease, such as Parkinson's disease.
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Norketotifen
0 ImagesCat. No.: HY-W665882CAS No.: 34580-20-6Norketotifen is the active metabolite of Ketotifen (HY-B0157). Norketotifen exhibits skin anti-inflammatory activity, anti-malarial activity, and antipruritic activity against non-histamine-mediated dog itching in mice. Norketotifen effectively inhibits TNF-α release without causing any sedative side effects. Norketotifen can be used for research on non-sedating anti-inflammatory agents.
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Quercetin 7-glucuronide (Standard)
0 ImagesCat. No.: HY-W778608RCAS No.: 38934-20-2Synonyms: Quercetin 7-O-β-glucuronide (Standard)Dopamine (hydrochloride) (Standard) is the analytical standard of Dopamine (hydrochloride). This product is intended for research and analytical applications. Dopamine hydrochloride (ASL279) is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine hydrochloride (ASL279) plays several important roles in the brain and body. Dopamine hydrochloride (ASL279) acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis.
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Formononetin 7-O-β-D-glucuronide
0 ImagesCat. No.: HY-128532CAS No.: 18524-03-3Formononetin 7-O-β-D-glucuronide is a metabolite of Formononetin (HY-N0183) and can be absorbed and metabolized through the intestine.
